{"id":9919,"date":"2022-01-04T11:37:18","date_gmt":"2022-01-04T16:37:18","guid":{"rendered":"https:\/\/www.med.unc.edu\/psych\/?p=9919"},"modified":"2022-01-04T11:37:18","modified_gmt":"2022-01-04T16:37:18","slug":"unc-awarded-3-9-million-grant-to-study-perimenopausal-onset-anhedonia-and-psychosis-with-simultaneous-pet-mr","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/psych\/unc-awarded-3-9-million-grant-to-study-perimenopausal-onset-anhedonia-and-psychosis-with-simultaneous-pet-mr\/","title":{"rendered":"UNC Awarded $3.9-million grant to study perimenopausal-onset anhedonia and psychosis with simultaneous PET-MR"},"content":{"rendered":"<div><a href=\"https:\/\/www.med.unc.edu\/psych\/directory\/gabriel-dichter\/\" target=\"_blank\" rel=\"noopener noreferrer\">Gabriel Dichter<\/a> (UNC Psychiatry), <a href=\"https:\/\/www.med.unc.edu\/psych\/directory\/crystal-schiller\/\" target=\"_blank\" rel=\"noopener noreferrer\">Crystal Schiller<\/a> (UNC Psychiatry), and <a href=\"https:\/\/bme.unc.edu\/peoples\/david-lalush\/\" target=\"_blank\" rel=\"noopener noreferrer\">David Lalush<\/a> (Joint Department of Biomedical Engineering) have been awarded a 5-year $3.9-million grant from the National Institute of Mental Health to use simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR) to examine the effects of estradiol on reward circuitry functioning in a transdiagnostic sample of women with perimenopausal-onset anhedonia and psychosis.<\/div>\n<div><\/div>\n<div>The project will evaluate whether the mesolimbic dopamine system is impaired in perimenopausal-onset anhedonia and psychosis as well as the effects of estradiol on striatal responses to rewards measured by fMRI and striatal dopamine functioning measured by PET. The hope is that this project will increase our understanding of anhedonia and psychosis vulnerability during the menopause transition and have the potential to deliver validated molecular imaging targets to use in future mechanistic trials of novel treatments for perimenopausal-onset psychiatric disorders.<\/div>\n<div><\/div>\n<div>Co-investigators on the project include Fred Jarskog (UNC Psychiatry), Erin Walsh (UNC Psychatry), Eric Smith (UNC Radiology), and Lauren Schiff (UNC Obstetrics and Gynecology).<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Gabriel Dichter (UNC Psychiatry), Crystal Schiller (UNC Psychiatry), and David Lalush (Joint Department of Biomedical Engineering) have been awarded a 5-year $3.9-million grant from the National Institute of Mental Health to use simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR) to examine the effects of estradiol on reward circuitry functioning in a transdiagnostic &hellip; <a href=\"https:\/\/www.med.unc.edu\/psych\/unc-awarded-3-9-million-grant-to-study-perimenopausal-onset-anhedonia-and-psychosis-with-simultaneous-pet-mr\/\" aria-label=\"Read more about UNC Awarded $3.9-million grant to study perimenopausal-onset anhedonia and psychosis with simultaneous PET-MR\">Read more<\/a><\/p>\n","protected":false},"author":103208,"featured_media":9920,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-9919","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>UNC Awarded $3.9-million grant to study perimenopausal-onset anhedonia and psychosis with simultaneous PET-MR | Department of Psychiatry<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/psych\/unc-awarded-3-9-million-grant-to-study-perimenopausal-onset-anhedonia-and-psychosis-with-simultaneous-pet-mr\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UNC Awarded $3.9-million grant to study perimenopausal-onset anhedonia and psychosis with simultaneous PET-MR | Department of Psychiatry\" \/>\n<meta property=\"og:description\" content=\"Gabriel Dichter (UNC Psychiatry), Crystal Schiller (UNC Psychiatry), and David Lalush (Joint Department of Biomedical Engineering) have been awarded a 5-year $3.9-million grant from the National Institute of Mental Health to use simultaneous positron emission tomography and functional magnetic resonance imaging (PET-MR) to examine the effects of estradiol on reward circuitry functioning in a transdiagnostic &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/psych\/unc-awarded-3-9-million-grant-to-study-perimenopausal-onset-anhedonia-and-psychosis-with-simultaneous-pet-mr\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Psychiatry\" \/>\n<meta property=\"article:published_time\" content=\"2022-01-04T16:37:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/psych\/wp-content\/uploads\/sites\/839\/2022\/01\/VitalSigns.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1920\" \/>\n\t<meta property=\"og:image:height\" content=\"1080\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"samweiss\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta 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