Xiaoyang Hua

Hua

Degrees:

MD:
(1996) Tongji Medical College
Huazhong University of Science & Technology
China

MS:
(2002)  Tongji Medical College
Huazhong University of Science & Technology
China

Residency:
(2001) Tongji Medical College
Huazhong University of Science & Technology
China

Fellowship:
(2002: Tongji Medical College
Huazhong University of Science & Technology
China

Academic Title:
Assistant Professor of Medicine

Office: 919-843-1955
Lab Phone: 919-843-2581
Fax: 919-843-1116
Email: xiaoyang_hua@med.unc.edu

Research Interests:

  1. Using genetic and pharmacological approaches to identify the pathogenesis of inflammatory diseases in both upper and lower airways and to explore novel therapeutic targets.
  2. Regulation of mucociliary clearance in both upper and lower airways and how impaired mucociliary clearance contributes to inflammatory diseases in both upper and lower airways.
  3. Adenosine biology in lungs and airways

Selected Publications:

  1. Hua X, Chason KD, Fredholm BB, Deshpande DA, Penn RB, Tilley SL. Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells. J Allergy Clin Immunol. 2008 Jul; 122(1):107-13, 113.e1-7.
  2. Ben Addi A, Lefort A, Hua X, Libert F, Communi D, Ledent C, Macours P, Tilley SL, Boeynaems JM, Robaye B. Modulation of murine dendritic cell function by adenine nucleotides and adenosine: involvement of the A(2B) receptor. Eur J Immunol. 2008 Jun; 38(6):1610-20.
  3. Hua X, Erikson CJ, Chason KD, Rosebrock CN, Deshpande DA, Penn RB, Tilley SL. Involvement of A1 adenosine receptors and neural pathways in adenosine-induced bronchoconstriction in mice. Am J Physiol Lung Cell Mol Physiol. 2007 Jul;293(1):L25-32. Epub 2007 Apr 27.
  4. Coffman LG, Brown JC, Johnson DA, Parthasarathy N, D'Agostino RB Jr, Lively MO, Hua X, Tilley SL, Muller-Esterl W, Willingham MC, Torti FM, Torti SV. Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin. Am J Physiol Lung Cell Mol Physiol. 2008 Mar; 294(3):L505-15.
  5. Hua X, Kovarova M, Chason KD, Nguyen M, Koller BH, Tilley SL. Enhanced mast cell activation in mice deficient in the A2b adenosine receptor. J Exp Med. 2007 Jan 22; 204(1):117-28.
  6. Tilley SL, Jaradat M, Stapleton C, Dixon D, Hua X, Erikson CJ, McCaskill JG, Chason KD, Liao G, Jania L, Koller BH, Jetten AM. Retinoid-related orphan receptor gamma controls immunoglobulin production and Th1/Th2 cytokine balance in the adaptive immune response to allergen. J Immunol. 2007 Mar 1; 178(5):3208-18.
  7. McCaskill JG, Chason KD, Hua X, Neuringer IP, Ghio AJ, Funkhouser WK, Tilley SL. Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice. Am J Respir Cell Mol Biol. 2006 Sep; 35(3):347-56. Epub 2006 Apr 27.