Retrospective MRI Analysis of Hepatocellular Carcinoma Following Ablation or External Beam Therapy (PI: Lauren Burke)

Purpose: To watch the natural progression of Hepatocellular Carcinoma (HCC) in patients for up to a 2 year period after they have been treated with ablation or external beam therapy, and to study the correlation between the type of therapy to the progression rate of HCC.

Participants: HCC patients treated with ablation or external beam therapy between Jan 1, 2011-Dec 31, 2015.

Procedures (methods): Retrospective evaluation of all patients who have been treated with the previously mentioned ablation therapies or external beam therapy for the treatment of HCC during a four year time span (January 1, 2011 to December 31, 2015). Patients will be retrospectively identified by conducting a search of radiology procedure codes for the above ablation therapies. Patients who fit the above criteria and who have a pre-treatment MRI of the abdomen within three months of the index ablation as well as at least 6 months of post-treatment MRI examinations will be included for review. All patients will be over 18 years of age. An Epic chart review will be conducted to determine the patient’s age, underlying etiology of chronic liver disease, and clinical follow-up. Patients will be studied for up to 2 years following the index ablation therapy (only up to March 3 2017, as anywhere from 6 months-2 yrs post ablation information will be acceptable for study purposes). At least two radiologists with expertise in abdominal MRI will review all MRI examinations and assign patients to three categories: 1. LI-RADS treated-viable, 2. LI-RADS treated-nonviable, 3. LI-RADS treated-equivocal, based on newly updated criteria for LI-RADS (Liver Imaging Reporting and Data System), a standardized reporting system from the American College of Radiology.

Clinical MRI Examination of Patients with Implantable Cardiac Devices (PI: William Hyslop)

Purpose: To study MRI examination for patients with implantable cardiac devices. To ensure patients safety as well as device functionality after scan. Project will quantify the percentage of patients for which the study cannot be completed and the likelihood of completing an MRI examination in this patient population without adverse outcome or significant change in the cardiac device’s operating parameters.

Participants: 300 patients (adult and pediatric) with a cardiac device who had a clinical MRI ordered between June 1, 2016 and December 1, 2018.

Procedures (methods): We will conduct a retrospective review of patients with a cardiac device who had a clinical MRI. Descriptive statistics will be used to assess the number of patients for which a study was ordered, number of patients who were approved to undergo an MRI study, number of patients who completed the MRI study, patients whose studies were not limited as a consequence of the study, and number of patients who had device complications as a consequence of the MRI study.