Molecular Imaging and Therapeutics Retrospective Studies
Collecting and analyze data from patients who underwent Meckel’s scan (PI: Bobby Huynh)
Purpose: Analyze largely qualitative data to assess for trends, though basic counting and statistical functions and regression. Ultimately, our hope is that this investigation will support the incremental – albeit meaningful – improvement of patient care at UNC.
Participants: Conducting data from 200 pediatric patients that underwent a Meckel’s scan at UNC between December 1st, 2013 and November 30th, 2018.
Procedures (methods): This is a retrospective study to determine the contributing factor(s) underlying this altered biodistribution, including identifying whether there is a single causative factor, and characterizing the nature of the factor(s) (i.e., quality control issues vs. patient specific factors).
Positron Emission Tomography (PET) with 82-Rubidium (Rb) is use for cardiac imaging (PI: Amir Khandani)
Purpose: The purpose of this study is to assess the tumor uptake of Rb-82 qualitatively by calculating SUV and visual assessment.
Participants: Patients who have undergone a Rb cardiac PET/CT and a FDG PET/CT at UNC since introduction of Rb PET at UNC (July 1, 2007) until April 23, 2018.
Procedures (methods): We will retrospectively review Rb-82 PET scans, and assess tumor uptake visually and by calculating the SUV. This would help to get a better sense of the strength of tumor signal intensity on Rb-82 PET.
Retrospective analysis of FDG-PET for immunotherapy. (PI: Jorge Oldan)
Purpose: To determine the manifestations of immunotherapy response on FDG-PET
Participants: We will retrospectively review patients seen at UNC Health Care between January 1, 2006 and January 6, 2017 to receive immunotherapy and be monitored with FDG PET/CT.
Procedures (methods): Working from a list of patients with FDG PET/CT scans used to monitor immunotherapy for metastatic melanoma, we will review cases of FDG-avid reactions to immunotherapy and summarize their types and frequency, as well as the duration of any suchr reactions.
A retrospective comparison of histopathological and radiographic scintigraphy findings in a cohort of patients treated for condylar hyperplasia. (PI: Jorge Oldan)
Purpose: Using a cohort of patients treated for condylar hyperplasia in the UNC Department of Oral and Maxillofacial Surgery, this study aims to compare radiographic scintigraphy findings with post-operative histopathologic findings of affected and resected condyles. Areas studied will include: Changes in radiotracer uptake with demographics such as age and skeletal maturity; correlation of histochemistry with diagnosis and/or relative tracer uptake by the condyle; and correlation of tracer uptake with hemimandibular hyperplasia vs elongation.
Participants: A cohort of approximately 100 patients with condylar hyperplasia seen by the department of Oral and Maxillofacial Surgery in the past 10 years and referred to Nuclear Medicine Radiology for SPECT scans; and approximately 50 of these patients who underwent resection of the condylar head as treatment and had the resected tissue submitted for histopathologic study.
Procedures (methods): This is a pilot study, using only archival material (entirely retrospective). Radiology studies will be reviewed independently from saved pathology specimens from the past 10 years. No new material will be obtained. Some of these patients are being followed for long-term follow-up, but no clinical decisions or treatment plans will be made based on the findings of this study.
Identifying trends in diagnosis of vulvar and vaginal cancer (PI: Jorge Oldan)
Purpose: To evaluate practice patterns for treatment of vulvar and vaginal cancer and identify characteristics of diagnostic delays. There is evidence that many women with vulvar or vaginal cancer have symptoms for many months prior to diagnosis and frequently undergo inappropriate treatments creating delays in care.
Participants: Women at a single institution who have been diagnosed with vulvar or vaginalcancer from Jan 1, 2009 to July 31st 2015.
Procedures (methods): A retrospective chart review will be performed of all gynecologic oncology patients at the University of North Carolina Hospitals from Jan 1 2009-July 31 2015. We will then extract demographic data, patient characteristics, treatments provided, and prior treatments provided prior to diagnosis.