This research program is headed by Dr. Sha Chang and involves development of novel radiation research and clinical devices based on carbon nanotube (CNT) field emission technology (FE).

The program leverages a close research collaboration with Dr. Otto Zhou’s group in the department of Physics & Astronomy. The multidisciplinary research team includes medical physicists, material scientists, and cancer biologists. Field emission is a quantum effect that emits electrons from a cathode under the control of a surface electronic field. CNTs are excellent field emitters and CNT field emission technology has been used in Zhou’s group to develop medical imaging devices such as micro-CT for animal model research and tomosynthesis for clinical application. Our program is focused on the development of CNT field emission technology applications in radiation oncology. We currently (as of 2010) have several research projects funded by NIH grants to develop CNT field emission based single cell Irradiation, micro-CT and micro-RT systems.

Publications

  • “Development of a carbon nanotube based low -LET multi-pixel microbeam array”, S. Chang, J. Zhang, D. Bordelon, E. Schreiber, A. Cox, O. Zhou. Rad. Res 166, 658-659 (2006).
  • “A stationary scanning X-ay imaging system based on carbon nanotube field emitters”, J. Zhang, G. Yang, R. Rajaram, E. Guan, Y. Lee, D. LaLush, S. Chang, J.P. Lu, O. Zhou, Medical Physics 33 (6): 2159, JUN 2006
  • “A carbon nanotube based low LET multi-microbeam array singel cell irradiation system”, S. Chang, J. Zhang, D. Bordelon, E. Schrieber, A. Cox, O. Zhou,Medical Physics (6): 2271, JUN 2006
  • “Multiplexing radiography using a carbon nanotube based x-ray tube”, J. Zhang, G. Yang, Y.Z. Lee, S. Chang, J.P. Lu, O. Zhou, Applied Physics Letters 89, 1 (2006)
  • “A multi-beam x-ray imaging system based on carbon nanotube field emitters”, J. Zhang, G. Yang, Y. Z. Lee, Y. Cheng, B. Gao, Q. Qiu, J. P. Lu, and O. Zhou, Proc. SPIE Vol. 6142, 614204 (2006)
  • “Development of a carbon nanotube based microfocus x-ray tube with single focusing electrode”, Z. Liu, J. Zhang, G. Yang, Y. Cheng, O. Zhou, and J.P. Lu, Rev. Sci. Instrum. 77, 054302 (2006)
  • “Field Emission of Electrons from Single LaB6 Nanowires”, Han Zhang, Qi Zhang, Guang Yang, Jian Zhang, Jie Tang, Otto Zhou and Lu-Chang Qin, Adv. Mater. Vol 18, Issue 1, 87-91(2006)
  • “Tomosynthesis reconstruction from multi-beam x-ray sources”, David S. Lalush, Enzhuo Quan, Ramya Rajaram, Jian Zhang, Jianping Lu, and Otto Zhou, Proceeding of 2006 IEEE International Symposium on Biomedical Imaging
  • Multiplexing Radiography for Ultra-Fast Computed Tomography: A Feasibility Study”, J Zhang, G Yang, Y Lee, S Chang, J Lu, O Zhou, Med. Phys. 34, 2527 (2007)
  • “Feasibility Study of a Carbon Nanotube Field Emission Microbeam System for Cellular Irradiation” S Chang, J Zhang, D Bordelon, S Graboski, E Schreiber, A Cox, and O Zhou, Med. Phys. 34, 2455 (2007)
  • “Monte Carlo Simulation and Design of a Carbon Nanotube Small-Animal Micro-RT System”. E Schreiber and S Chang. Med. Phys. 34, 2332 (2007)