{"id":4080,"date":"2011-02-24T11:49:40","date_gmt":"2011-02-24T16:49:40","guid":{"rendered":"https:\/\/www.med.unc.edu\/radonc\/?p=4080"},"modified":"2020-04-29T15:27:41","modified_gmt":"2020-04-29T19:27:41","slug":"breast-cancer-spore","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/radonc\/breast-cancer-spore\/","title":{"rendered":"Breast Cancer SPORE"},"content":{"rendered":"

Goal: use a team approach to review cases before treatment begins, rather than after treatment decisions have been made.<\/p>\n

\n

UNC\u2019s multidisciplinary breast cancer program has been a thriving example of true multidisciplinary care for the past 15 years. \u00a0Unlike many programs that have multidisciplinary tumor boards that meet to review cases after treatment decisions have been made, UNC takes a true \u201cteam approach\u201d. \u00a0Patients are seen on the same day as the tumor board by all disciplines, and the multidisciplinary treatment recommendations are made by the group. \u00a0This allows co-ordination of treatment care, consensus recommendations, and fosters interdisciplinary treatment trials.<\/p>\n

UNC\u2019s breast program is nationally renowned. \u00a0We have been designated as a SPORE for the past 20 years. \u00a0Radiation oncologist Dr. Sartor is Co-Director of the breast program, and leads two of five SPORE research projects. \u00a0Our emphasis is on \u201ctranslational research\u201d, bringing bench laboratory research to clinical trials. \u00a0Dr. Sartor\u2019s active laboratory research has led to a number of exciting and innovative clinical trials that are available only at UNC. \u00a0UNC is also very active in the CALGB national clinical trials group; Dr. Sartor is Vice-Chair of the Radiation Oncology Committee, a core member of the Breast Committee, and serves on the Executive Committee. \u00a0As such, UNC also participates in ongoing and upcoming large-scale CALGB clinical trials, with Dr. Sartor serving the role of directing radiotherapy aspects of these national trials. Additional Details\u2192<\/span><\/a><\/p>\n

Highlights of UNC breast clinical trials:<\/strong><\/p>\n

LCCC0411:\u00a0 This trial follows on Dr. Sartor\u2019s laboratory studies of the EGFR\/HER2 inhibitor, lapatinib (Tykerb), that indicate that lapatinib may be an effective radiosensitizer for locally advanced breast cancer. \u00a0It is a Phase I study for patients with locally recurrent breast cancer (prior radiation allowed) that tests the dose of lapatinib that is tolerated with radiation. \u00a0An important aspect of the trial is that samples of the tumor are obtained to study the biological basis of how lapatinib makes breast cancer more sensitive to radiation.<\/p>\n

LCCC0218:\u00a0 This trial is for patients with very favorable early stage breast cancer, and tests whether a single dose of radiation delivered at the time of surgery in the operating room (intraoperative radiotherapy or IORT) is effective and well tolerated. \u00a0The goal of this Phase II study is to determine the feasibility of decreasing the radiation therapy from 5-6 weeks to a single day. \u00a0An important aspect of this trial is that samples of the tumor are obtained before and after irradiation to study how radiation affects breast cancer at the molecular level.<\/p>\n

All UNC cancer clinical trials<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Goal: use a team approach to review cases before treatment begins, rather than after treatment decisions have been made.<\/p>\n","protected":false},"author":73344,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[67],"tags":[6],"class_list":["post-4080","post","type-post","status-publish","format-standard","hentry","category-projects","tag-clinic-research","odd"],"acf":[],"yoast_head":"\nBreast Cancer SPORE | Department of Radiation Oncology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/radonc\/breast-cancer-spore\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Breast Cancer SPORE | Department of Radiation Oncology\" \/>\n<meta property=\"og:description\" content=\"Goal: use a team approach to review cases before treatment begins, rather than after treatment decisions have been made.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/radonc\/breast-cancer-spore\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Radiation Oncology\" \/>\n<meta property=\"article:published_time\" content=\"2011-02-24T16:49:40+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-04-29T19:27:41+00:00\" \/>\n<meta name=\"author\" content=\"Nick Perisich\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNCRadOnc\" \/>\n<meta name=\"twitter:site\" content=\"@UNCRadOnc\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/radonc\/breast-cancer-spore\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/radonc\/breast-cancer-spore\/\"},\"author\":{\"name\":\"Nick Perisich\",\"@id\":\"https:\/\/www.med.unc.edu\/radonc\/#\/schema\/person\/5afbd02e04a64ce4bbbe794a0e1ce216\"},\"headline\":\"Breast Cancer SPORE\",\"datePublished\":\"2011-02-24T16:49:40+00:00\",\"dateModified\":\"2020-04-29T19:27:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/radonc\/breast-cancer-spore\/\"},\"wordCount\":429,\"keywords\":[\"Research - 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