The Department of Veterans Affairs awarded Dr. Melina Kibbe, MD, Chair, and Professor at UNC Surgery, with the Biomedical Laboratory R&D Senior Clinical Scientist Award. She received the award for her project entitled, “Novel in situ custom biodegradable drug-eluting stents for endovascular surgery.\u201d She and her team are excited about the opportunity that this award affords them, allowing them to pursue advances in vascular medicine.<\/p>\n
Cardiovascular disease is the leading cause of death in developed countries.\u00a0 A common treatment for atherosclerotic cardiovascular disease is the placement of an arterial stent.\u00a0 While stent technology has improved over the years, including the development of drug-eluting stents, failure rates remain high and current technologies are associated with significant challenges.\u00a0 Thus, there is a great need for new stent technology that will improve patient outcomes following percutaneous cardiac and peripheral vascular interventions.\u00a0 She and her team are proposing to develop an innovative, paradigm-shifting stent technology that will obviate the need for the placement of permanent metal stents in the arterial system for the treatment of severe atherosclerosis.\u00a0 Specifically, they propose to develop a solid biodegradable stent from a liquid drug-eluting polymer by photo-polymerizing the stent in the body<\/em> using a specially designed triple balloon catheter.<\/strong>\u00a0 This \u201cdesigner therapy\u201d will be tailored to the contours of the individual artery and coat the entire surface of the artery, significantly reducing the thrombogenic potential at the site of injury and providing the greatest surface area for drug delivery.<\/p>\n Through their multidisciplinary team of investigators and industry engineers, we have already demonstrated the feasibility of our project through preliminary data.\u00a0 It is now time to focus on developing and optimizing the drug releasing capacity of the polymeric stent and conducting the in vivo<\/em> preclinical studies necessary to translate this technology to the clinical arena.\u00a0 Thus, the specific aims of this project are: 1) Develop and optimize a NO-eluting, liquid-cast PDDC stent using diazeniumdiolate and S-nitrosothiol chemistry; 2) Evaluate and tune the mechanical properties of the NO-eluting, liquid-cast PDDC stent ex vivo<\/em>; 3) Examine the safety and efficacy of the NO-eluting, liquid-cast PDDC stent in vivo<\/em>.\u00a0 Our novel approach challenges the existing paradigm for arterial stenting and will lead to a radical departure in the treatment of atherosclerotic occlusive disease.\u00a0 Through our preliminary data, we have demonstrated the feasibility of this project.\u00a0 Given the burden of atherosclerotic disease in the veteran population, the studies in this proposal will result in a new technology that will be translated to improved veteran health.<\/p>\n","protected":false},"excerpt":{"rendered":" The Department of Veterans Affairs awarded Dr. Melina Kibbe, MD, Chair, and Professor at UNC Surgery, with the Biomedical Laboratory R&D Senior Clinical Scientist Award. She received the award for her project entitled, \u201cNovel in situ custom biodegradable drug-eluting stents for endovascular surgery.\u201d<\/p>\n","protected":false},"author":83776,"featured_media":10472,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[66,105,106,107,67],"featured-item":[],"class_list":["post-10446","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-chapel-hill","tag-kibbe","tag-kibbe-lab","tag-unc-healthcare","tag-vascular-surgery","odd"],"pp_force_visibility":null,"pp_subpost_visibility":null,"pp_inherited_force_visibility":null,"pp_inherited_subpost_visibility":null,"acf":[],"yoast_head":"\n