{"id":12520,"date":"2021-03-18T11:26:08","date_gmt":"2021-03-18T15:26:08","guid":{"rendered":"https:\/\/www.med.unc.edu\/surgery\/?p=12520"},"modified":"2021-12-16T06:48:32","modified_gmt":"2021-12-16T11:48:32","slug":"stephanie-downs-canner-awarded-unc-lineberger-development-award","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/surgery\/stephanie-downs-canner-awarded-unc-lineberger-development-award\/","title":{"rendered":"Stephanie Downs-Canner Awarded UNC Lineberger Development Award"},"content":{"rendered":"

\"StephanieCongratulations to Stephanie Downs-Canner, MD, Assistant Professor in the Division of Surgical Oncology and Endocrine Surgery on receiving a UNC Lineberger Development Award.<\/h4>\n

The UNC Lineberger Developmental Funding Program is intended to support the development of cancer research led by the faculty of the University of North Carolina at Chapel Hill and to stimulate new applications for extramural funding. All UNC Lineberger Comprehensive Cancer Center members, UNC-Chapel Hill faculty, and UNC system school faculty are encouraged to apply.<\/p>\n

Dr. Downs-Canner and her co-investigator Jonathan Serody, MD, the Elizabeth Thomas Professor of Medicine, in the Division of Microbiology and Immunology in the Department of Medicine were awarded a Tier 2 stimulus award of $200,000 for their project titled, “Characterizing the Endogenous Antibody Response in Triple Negative Breast Cancer.” Their collaborators include Benjamin Vincent, MD, an Assistant Professor of Medicine, and\u00a0 Laura Herring, Ph.D. Assistant Professor and Director, Michael J. Hooker Proteomics Core.<\/p>\n

The\u00a0Tier 2 Stimulus Award\u00a0<\/a>is intended to support innovative research initiatives aimed at obtaining sufficient data to allow new applications for extramural funding. Tier 2 may have a larger budget and\/or a longer time-frame than Tier 1, and require preliminary data to support the research questions.<\/p>\n

Scientific abstract:<\/p>\n

Breast cancer is the leading cause of cancer-related death in women. Triple negative breast cancer (TNBC)
\nhas the worst prognosis of all breast cancer subtypes and treatment options are limited to traditional cytotoxic
\nchemotherapy. Unlike other cancers, where T-cells play a critical role, recent data has shown that in TNBC, Bcells
\nin the tumor microenvironment (TME) are predictive of an improved outcome and may play a role in
\neffective immunotherapy for TNBC. Using single-cell RNA sequencing of human breast cancers, we have
\nidentified at least 9 distinct clusters of B-cells in the TME as well as clonal restriction of B-cell receptors
\n(suggestive of a tumor-antigen specific immune response). The overall goal of this proposal is to understand
\nthe activity of B cells in TNBC and use clonally restricted B-cells to identify novel antigen targets. In Aim 1, we
\nwill use single-cell RNA sequencing of tumor-infiltrating immune cells to test our hypothesis that B-cells in
\nTNBC undergo clonal selection and affinity maturation in a germinal center reaction to yield clonally expanded
\nB-cells that are phenotypically distinct from non-clonally expanded B-cells. In Aim 2, we will clone antibodies
\nfrom the most abundant B-cell clones to discover antigens and test our hypothesis that B-cells recognize
\nendogenous antigens present in the TME that 1) mediate anti-tumor activity and 2) make antibodies that
\nrecognize shared determinants present in different patients. The identification of these antibodies can be used
\nas potential therapeutic or diagnostic approaches for women with TNBC.<\/p>\n","protected":false},"excerpt":{"rendered":"

Congratulations to Stephanie Downs-Canner, MD, Assistant Professor in the Division of Surgical Oncology and Endocrine Surgery on receiving a UNC Lineberger Development Award. The UNC Lineberger Developmental Funding Program is intended to support the development of cancer research led by the faculty of the University of North Carolina at Chapel Hill and to stimulate new … Read more<\/a><\/p>\n","protected":false},"author":83776,"featured_media":12522,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[220,268,2,208],"tags":[222,199,124,221],"featured-item":[],"class_list":["post-12520","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-award","category-grants-funding","category-news","category-research","tag-downs-canner","tag-news-2021","tag-research","tag-unc-lineberger-cancer-center","odd"],"pp_force_visibility":null,"pp_subpost_visibility":null,"pp_inherited_force_visibility":null,"pp_inherited_subpost_visibility":null,"acf":[],"yoast_head":"\nStephanie Downs-Canner Awarded UNC Lineberger Development Award | Department of Surgery<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/surgery\/stephanie-downs-canner-awarded-unc-lineberger-development-award\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Stephanie Downs-Canner Awarded UNC Lineberger Development Award | Department of Surgery\" \/>\n<meta property=\"og:description\" content=\"Congratulations to Stephanie Downs-Canner, MD, Assistant Professor in the Division of Surgical Oncology and Endocrine Surgery on receiving a UNC Lineberger Development Award. 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