Researchers from the Thurston Arthritis Research Center at the University of North Carolina at Chapel Hill, presented ongoing research at the 2012 Annual Meeting of the American Academy of Allergy Asthma & Immunology (AAAAI) held in Orlando, FL, March 2-6.
Teresa Tarrant, MD, and her group presented two posters titled "GRK3 deficiency enhances parathyroid hormone (PTH) receptor function on bone marrow mesenchymal stem cells and may enhance hematopoiesis" and "Immunologic phenotype of GRK3-null mice at baseline and in inflammatory disease." These posters discuss data on a novel protein kinase that has anti-inflammatory function in arthritis and autoimmunity. Further work suggests this kinase may be important in stem cell biology and hematopoiesis.
Edwin Kim, MD, presented a poster titled "Induction of regulatory T cells after peanut sublinqual immunotherapy." This study explored the possible role of regulatory T cells in the desensitization of allergic children with peanut sublingual immunotherapy (SLIT). Sixteen children participated in a 12 month course of peanut SLIT followed by a double-blind, placebo-controlled food challenge. The study showed that the percentage of regulatory T cells increased significantly and the children had increased tolerance to peanuts.
Dr. Edwin Kim
Posters were also presented by Amy Auerbach, MD, titled "Endotoxin challenge increase production of IL-1β in the peripheral blood but not in sputum of allergic asthmatics," and by Claire Chehrazi, MD, titled "Diesel exhaust alters nasal innate immune mechanisms in allergic rhinitics."
Dr. Claire Chehraz
This annual meeting of the AAAAI is the world's premier gathering of allergy and immunology experts in clinical and translational science. Allergy/immunology specialty's academic and clinical leaders showcase new research and discuss other developments in allergy, asthma and immunologic diseases. The meeting is attended by more than 7,700 allergist/immunologists, related physicians, allied health professionals and industry representatives.