Professor of Chemistry, Adjunct Professor of Medicine
Specialty Areas: General Rheumatology
Chronology: B.S.: Auburn University at Montgomery, 1980; M.D.: Johns Hopkins University School of Medicine, 1984; Resident in Internal Medicine, Beth Israel Deaconess Medical Center, 1984-1987; Instructor in Medicine, Harvard Medical School, 1987-1988; Fellow in General Internal Medicine, Stanford Center for Research in Disease Prevention, 1988-1990; Clinical Fellow in Rheumatology, Stanford University Hospital, 1990-1993; Resident in Physical Medicine and Rehabilitation, Stanford University Hospital, 1993-1994; Research Fellow, Physiology & Biophysics, University of California, Irvine, 1994-1998; Assistant/Associate Professor, Dept. of Physiology & Biophysics, UCI, 1998-2007; Research Professor, Dept. of Chemistry, University of North Carolina, Chapel Hill, 2007-present; Adjunct Professor, Dept. of Medicine/Rheumatology, UNC 2007-present.
Description of research and/or clinical interests: Dr. Sims’ research is based on a multidisciplinary and translational effort that brings to bear principles and techniques from chemistry, engineering, and medicine to develop new assays and technologies for biomedical applications. The ongoing projects he is actively pursuing comprise three major focus areas: 1) analytical techniques for single-cell biochemical assays, 2) microfabricated platforms for isolating single cells for genetic analyses and cloning, and 3) microengineered systems for recapitulating organ level function. Many of the lab’s projects and extensive collaborations within these focus areas involve the development and application of new technologies for oncology and stem cell research. A common thread in his research is the development and application of new technologies for biomedical research with a goal for clinical translation. He has a multidisciplinary research and clinical background, being double-boarded in Internal Medicine and Rheumatology. His postdoctoral research training was in the Department of Physiology & Biophysics at UC Irvine where he developed novel microanalytical tools for intracellular enzyme assays and platforms for cell sorting. He has been the PI or co-investigator on several NIH-funded research projects in collaboration with some of the pre-eminent scientists in the fields of analytical chemistry, bioengineering and biomedical science.
For a list of published work see: http://www.ncbi.nlm.nih.gov/pubmed/?term=sims+ce[au]