Driving Science With Increasingly Sophisticated and Powerful Technologies

Purpose

Richard Loeser, MD; and Amanda Nelson, MD; Co-Directors of the Phenotyping and Precision Medicine Resource Core

The Phenotyping and Precision Medicine Resource Core provides critical services to our research community that broadly include:

  • Key scientific expertise and analytic resources needed for Prognostic and Prescriptive Phenotyping
    1. Prognostic phenotyping (predicting outcomes by specific subgroups, e.g., “progressors” versus “non-progressors”)
    2. Prescriptive phenotyping (e.g., predicting response to specific interventions)
  • Guidance and advice to investigators on phenotypic considerations (such as choice of input and outcome variables) in order to enhance the design, implementation, and interpretation of new clinical studies and trials.

Setting You Up For Success

Steve Marron, PhD; and Michael Kosorok, PhD; Associate Directors of the Phenotyping and Precision Medicine Resource Core

Like many chronic conditions, Rheumatic and Musculoskeletal Diseases (RMDs) including osteoarthritis (OA), are not single diseases but rather heterogeneous conditions consisting of multiple phenotypes that differ in their underlying pathobiological mechanisms.

If not taken into consideration, these differences result in the testing of interventions designed to address specific mechanisms of action in the “wrong” patients.

Successful treatments for RMDs therefore need to be targeted to, and tested in, specific subgroups or subtypes that share distinct underlying pathobiological, psychosocial and pain mechanisms, consistent with the goal of precision medicine.

The Phenotyping and Precision Medicine Resource Core works in conjunction with the Methodology Core to provide services that will greatly enhance study design and add value to a wide spectrum of ongoing, completed, and planned clinical studies through the following aims:

Phenotyping and Precision Medicine Resources Core Aims:

  • Provide consultative advice and analytical services for prognostic and prescriptive phenotyping for investigators interested in defining subgroups within new or ongoing clinical studies in OA or other RMDs, including ancillary studies and studies in the planning stages.  
  • Apply innovative strategies for phenotyping and precision medicine by leveraging data collected in selected clinical studies from our research community, adding value to those studies while  facilitating external validation and informing future studies.
  • Encourage broader implementation of phenotyping and precision medicine approaches for RMDs through education and dissemination of the methodologies to local, national, and international research communities. Having a resource core dedicated to phenotyping and precision medicine greatly benefits the research community supported by the CCCR, makes a significant impact on the field of clinical RMD research, and ultimately makes a difference in the lives of people suffering from these chronic and disabling conditions.

For more information, or to speak with someone regarding our Phenotyping and Precision Medicine Core, please contact:  Amanda Nelson, MD: Amanda_Nelson@med.unc.edu; or Richard Loeser, MD: Richard_Loeser@med.unc.edu.

To initiate the process of requesting information, data, and/or collaboration from UNC’s CCCR, please complete and submit this form.