1.0Thurston Arthritis Research Centerhttps://www.med.unc.edu/tarcJeffrey Perkinshttps://www.med.unc.edu/tarc/author/jrperki3/rich600338<blockquote class="wp-embedded-content" data-secret="L3QTsL0x3w"><a href="https://www.med.unc.edu/tarc/maximizing-investigators-research-award/">Doug Phanstiel, PhD, Awarded National Institute of General Medical Sciences (NIGMS) R35 “Maximizing Investigators’ Research Award” (MIRA) Grant To Study Mechanisms of Chromatin Looping During Differentiation</a></blockquote><iframe sandbox="allow-scripts" security="restricted" src="https://www.med.unc.edu/tarc/maximizing-investigators-research-award/embed/#?secret=L3QTsL0x3w" width="600" height="338" title="“Doug Phanstiel, PhD, Awarded National Institute of General Medical Sciences (NIGMS) R35 “Maximizing Investigators’ Research Award” (MIRA) Grant To Study Mechanisms of Chromatin Looping During Differentiation” — Thurston Arthritis Research Center" data-secret="L3QTsL0x3w" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" class="wp-embedded-content"></iframe><script type="text/javascript"> /* <![CDATA[ */ /*! This file is auto-generated */ !function(d,l){"use strict";l.querySelector&&d.addEventListener&&"undefined"!=typeof URL&&(d.wp=d.wp||{},d.wp.receiveEmbedMessage||(d.wp.receiveEmbedMessage=function(e){var t=e.data;if((t||t.secret||t.message||t.value)&&!/[^a-zA-Z0-9]/.test(t.secret)){for(var s,r,n,a=l.querySelectorAll('iframe[data-secret="'+t.secret+'"]'),o=l.querySelectorAll('blockquote[data-secret="'+t.secret+'"]'),c=new RegExp("^https?:$","i"),i=0;i<o.length;i++)o[i].style.display="none";for(i=0;i<a.length;i++)s=a[i],e.source===s.contentWindow&&(s.removeAttribute("style"),"height"===t.message?(1e3<(r=parseInt(t.value,10))?r=1e3:~~r<200&&(r=200),s.height=r):"link"===t.message&&(r=new URL(s.getAttribute("src")),n=new URL(t.value),c.test(n.protocol))&&n.host===r.host&&l.activeElement===s&&(d.top.location.href=t.value))}},d.addEventListener("message",d.wp.receiveEmbedMessage,!1),l.addEventListener("DOMContentLoaded",function(){for(var e,t,s=l.querySelectorAll("iframe.wp-embedded-content"),r=0;r<s.length;r++)(t=(e=s[r]).getAttribute("data-secret"))||(t=Math.random().toString(36).substring(2,12),e.src+="#?secret="+t,e.setAttribute("data-secret",t)),e.contentWindow.postMessage({message:"ready",secret:t},"*")},!1)))}(window,document); /* ]]> */ </script> https://www.med.unc.edu/tarc/wp-content/uploads/sites/802/2018/08/Tarc-New-Post-2.jpeg300400Dr. Phanstiel, a UNC Assistant Professor of Cell Biology & Physiology, and faculty member in the UNC Thurston Arthritis Research Center, has been awarded a 5-Year, $1.25 million grant for his research into how human cells regulate gene transcription during development. His research is focused on better understanding how DNA folds within the cell nucleus, specifically which proteins are involved in governing that folding, and how the resulting three-dimensional structure of chromatin regulates gene transcription. This research addresses fundamental questions regarding how our cells work and how each person’s unique DNA sequence contributes to their development and susceptibility to disease. The results will aid our understanding of a variety of human diseases ranging from arthritis to cancer.