{"id":4060,"date":"2016-06-22T20:17:00","date_gmt":"2016-06-23T00:17:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/tarc\/directory\/douglas-phanstiel\/"},"modified":"2025-01-03T09:55:02","modified_gmt":"2025-01-03T14:55:02","slug":"douglas-phanstiel","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/tarc\/directory\/douglas-phanstiel\/","title":{"rendered":"Douglas Phanstiel, PhD"},"content":{"rendered":"

<\/p>\n

Assistant Professor of Cell Biology & Physiology<\/p>\n

\n

Specialty Areas: <\/b>Genomics, Proteomics, Bioinformatics, <\/b>Genomic software development<\/p>\n

Chronology:
\n<\/b>BS: University of California \u2013 San Diego (Cell Biology & Biochemistry), 2001
\nPhD: University of Wisconsin \u2013 Madison (Chemistry), 2011
\nPost-doctoral fellow: Stanford University (laboratory of Michael P Snyder), 2011-2016
\nAssistant Professor of Cell Biology & Physiology: University of North Carolina at Chapel Hill, 2016-present<\/p>\n

Description of research and\/or clinical interests: <\/b>Dr. Phanstiel\u2019s lab studies transcriptional regulation during innate immune cell development both in healthy individuals and in the context of human disease. The lab is particularly interested in the mechanisms by which specific intergenic genomic loci, known as enhancers, influence transcriptional changes of genes hundreds of thousands of base pairs away. To accomplish their work the Phanstiel lab employs interdisciplinary techniques including DNA sequencing, bioinformatics, and genome editing applied to primary human cells and cell culture model systems.<\/p>\n

Selected Publications:<\/b><\/p>\n

1) Phanstiel DH<\/b>*, Van Bortle K*, Spacek D, Hess GT, Shamim MS, Machol I, Love MI, Aiden EL, Bassik MC, Snyder MP. Static and Dynamic DNA Loops form AP-1-Bound Activation Hubs during Macrophage Development. Molecular Cell<\/b>. 2017 Sep 21;67(6):1037-1048.e6. PubMed PMID: 28890333<\/a>; PubMed Central PMCID: PMC5610110<\/a>.<\/p>\n

2) Phanstiel DH<\/b>, Boyle AP, Heidari N, Snyder MP. Mango: a bias-correcting ChIA-PET analysis pipeline. Bioinformatics<\/b>. 2015 Oct 1;31(19):3092-8. PubMed PMID: 26034063<\/a>; PubMed Central PMCID: PMC4592333<\/a>.<\/p>\n

3) Heidari N*, Phanstiel DH*<\/b>, He C, Grubert F, Jahanbani F, Kasowski M, Zhang MQ, Snyder MP. Genome-wide map of regulatory interactions in the human genome. Genome Research<\/b>. 2014 Dec;24(12):1905-17. PubMed PMID: 25228660<\/a>; PubMed Central PMCID: PMC4248309<\/a>.<\/p>\n

4) Phanstiel DH<\/b>, Boyle AP, Araya CL, Snyder MP. Sushi.R: flexible, quantitative and integrative genomic visualizations for publication-quality multi-panel figures. Bioinformatics<\/b>. 2014 Oct;30(19):2808-10. PubMed PMID: 24903420<\/a>; PubMed Central PMCID: PMC4173017<\/a>.<\/p>\n

5) Phanstiel DH<\/b>*, Brumbaugh J*, Wenger CD, Tian S, Probasco MD, Bailey DJ, Swaney DL, Tervo MA, Bolin JM, Ruotti V, Stewart R, Thomson JA, Coon JJ. Proteomic and phosphoproteomic comparison of human ES and iPS cells. Nature Methods<\/b>. 2011 Sep 11;8(10):821-7. PubMed PMID: 21983960<\/a>; PubMed Central PMCID: PMC3432645<\/a>.<\/p>\n

6) Phanstiel D<\/b>, Brumbaugh J, Berggren WT, Conard K, Feng X, Levenstein ME, McAlister GC, Thomson JA, Coon JJ. Mass spectrometry identifies and quantifies 74 unique histone H4 isoforms in differentiating human embryonic stem cells. Proceedings of the National Academy Sciences<\/b>. U S A. 2008 Mar 18;105(11):4093-8. PubMed PMID: 18326628<\/a>; PubMed Central PMCID: PMC2393763<\/a>.<\/p>\n

Awards and Honors
\n<\/strong>2015: K99\/R00 Pathway to Independence
\n2012: Damon Runyon Fellowship Award<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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