{"id":16042,"date":"2024-07-15T10:58:03","date_gmt":"2024-07-15T14:58:03","guid":{"rendered":"https:\/\/www.med.unc.edu\/tarc\/?p=16042"},"modified":"2024-07-22T18:53:36","modified_gmt":"2024-07-22T22:53:36","slug":"the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/","title":{"rendered":"The Osteoarthritis Prevention Study (TOPS) Takes Off at UNC Clinical Site Led by Dr. Leigh Callahan"},"content":{"rendered":"

\"The<\/b><\/p>\n

 <\/p>\n

\"\"
Leigh Callahan, PhD<\/b><\/figcaption><\/figure>\n

Dr. Leigh F. Callahan is the Principal Investigator for the UNC Clinical Site of The Osteoarthritis Prevention Study (TOPS),\u00a0an extensive clinical study spanning two continents.\u00a0\u00a0The Thurston Arthritis Research Center is playing a key supporting role as one of the main study locations, both in terms of logistics as well as its globally recognized arthritis expertise. Other sites include Wake Forest University, Harvard University and the University of Sydney, Australia.<\/p>\n

The 5-year trial is funded by NIAMS, the Arthritis Foundation, and the CDC through a $17 million Wake Forest University grant, with more than $5 million going to UNC.\u00a0 The study builds on a previous OA pragmatic trial co-led by Dr. Callahan and Dr. Stephen Messier at Wake Forest University that showed that a weight loss and diet intervention led to greater than 20% pain relief in persons with knee osteoarthritis published in JAMA (link to article<\/a>).<\/p>\n

For the TOPS trial, UNC is actively recruiting 300 overweight women over age 50 without evidence of OA to participate in one of two intervention arms \u2013 weight loss and physical activity or healthy living.\u00a0 Other UNC co-investigators include Drs. Brian Pietrosimone, Richard Loeser, and Sandra Soto.\u00a0Dr. Cortney Armitano-Lago is the Project Manager.<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Dr. Leigh F. Callahan is the Principal Investigator for the UNC Clinical Site of The Osteoarthritis Prevention Study (TOPS),\u00a0an extensive clinical study spanning two continents.\u00a0\u00a0<\/p>\n","protected":false},"author":114753,"featured_media":16051,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-16042","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"\nThe Osteoarthritis Prevention Study (TOPS) Takes Off at UNC Clinical Site Led by Dr. Leigh Callahan | Thurston Arthritis Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Osteoarthritis Prevention Study (TOPS) Takes Off at UNC Clinical Site Led by Dr. Leigh Callahan | Thurston Arthritis Research Center\" \/>\n<meta property=\"og:description\" content=\"Dr. Leigh F. Callahan is the Principal Investigator for the UNC Clinical Site of The Osteoarthritis Prevention Study (TOPS),\u00a0an extensive clinical study spanning two continents.\u00a0\u00a0\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/\" \/>\n<meta property=\"og:site_name\" content=\"Thurston Arthritis Research Center\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/unctarc\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-15T14:58:03+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-22T22:53:36+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq.png\" \/>\n\t<meta property=\"og:image:width\" content=\"665\" \/>\n\t<meta property=\"og:image:height\" content=\"674\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"amiha\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@UNCTARC\" \/>\n<meta name=\"twitter:site\" content=\"@UNCTARC\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"amiha\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/\"},\"author\":{\"name\":\"amiha\",\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/#\/schema\/person\/5f08e147937c7b82481f64ec6356282f\"},\"headline\":\"The Osteoarthritis Prevention Study (TOPS) Takes Off at UNC Clinical Site Led by Dr. Leigh Callahan\",\"datePublished\":\"2024-07-15T14:58:03+00:00\",\"dateModified\":\"2024-07-22T22:53:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/\"},\"wordCount\":230,\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq.png\",\"articleSection\":[\"News\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/\",\"url\":\"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/\",\"name\":\"The Osteoarthritis Prevention Study (TOPS) Takes Off at UNC Clinical Site Led by Dr. Leigh Callahan | Thurston Arthritis Research Center\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq.png\",\"datePublished\":\"2024-07-15T14:58:03+00:00\",\"dateModified\":\"2024-07-22T22:53:36+00:00\",\"author\":{\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/#\/schema\/person\/5f08e147937c7b82481f64ec6356282f\"},\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq.png\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq.png\",\"width\":665,\"height\":674,\"caption\":\"graphic\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/tarc\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"The Osteoarthritis Prevention Study (TOPS) Takes Off at UNC Clinical Site Led by Dr. Leigh Callahan\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/tarc\/\",\"name\":\"Thurston Arthritis Research Center\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/tarc\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/#\/schema\/person\/5f08e147937c7b82481f64ec6356282f\",\"name\":\"amiha\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/tarc\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/626d87df4021821337bb351756e1167bff4bec890dfd0e5ba912b58f73a6c959?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/626d87df4021821337bb351756e1167bff4bec890dfd0e5ba912b58f73a6c959?s=96&d=mm&r=g\",\"caption\":\"amiha\"},\"url\":\"https:\/\/www.med.unc.edu\/tarc\/author\/amiha\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The Osteoarthritis Prevention Study (TOPS) Takes Off at UNC Clinical Site Led by Dr. Leigh Callahan | Thurston Arthritis Research Center","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/","og_locale":"en_US","og_type":"article","og_title":"The Osteoarthritis Prevention Study (TOPS) Takes Off at UNC Clinical Site Led by Dr. Leigh Callahan | Thurston Arthritis Research Center","og_description":"Dr. Leigh F. Callahan is the Principal Investigator for the UNC Clinical Site of The Osteoarthritis Prevention Study (TOPS),\u00a0an extensive clinical study spanning two continents.\u00a0\u00a0","og_url":"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/","og_site_name":"Thurston Arthritis Research Center","article_publisher":"https:\/\/www.facebook.com\/unctarc","article_published_time":"2024-07-15T14:58:03+00:00","article_modified_time":"2024-07-22T22:53:36+00:00","og_image":[{"width":665,"height":674,"url":"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq.png","type":"image\/png"}],"author":"amiha","twitter_card":"summary_large_image","twitter_creator":"@UNCTARC","twitter_site":"@UNCTARC","twitter_misc":{"Written by":"amiha","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/#article","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/"},"author":{"name":"amiha","@id":"https:\/\/www.med.unc.edu\/tarc\/#\/schema\/person\/5f08e147937c7b82481f64ec6356282f"},"headline":"The Osteoarthritis Prevention Study (TOPS) Takes Off at UNC Clinical Site Led by Dr. Leigh Callahan","datePublished":"2024-07-15T14:58:03+00:00","dateModified":"2024-07-22T22:53:36+00:00","mainEntityOfPage":{"@id":"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/"},"wordCount":230,"image":{"@id":"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq.png","articleSection":["News"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/","url":"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/","name":"The Osteoarthritis Prevention Study (TOPS) Takes Off at UNC Clinical Site Led by Dr. Leigh Callahan | Thurston Arthritis Research Center","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/tarc\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/#primaryimage"},"image":{"@id":"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/#primaryimage"},"thumbnailUrl":"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq.png","datePublished":"2024-07-15T14:58:03+00:00","dateModified":"2024-07-22T22:53:36+00:00","author":{"@id":"https:\/\/www.med.unc.edu\/tarc\/#\/schema\/person\/5f08e147937c7b82481f64ec6356282f"},"breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/#primaryimage","url":"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq.png","contentUrl":"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq.png","width":665,"height":674,"caption":"graphic"},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/tarc\/the-osteoarthritis-prevention-study-tops-takes-off-at-unc-clinical-site-led-by-dr-leigh-callahan\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/tarc\/"},{"@type":"ListItem","position":2,"name":"The Osteoarthritis Prevention Study (TOPS) Takes Off at UNC Clinical Site Led by Dr. Leigh Callahan"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/tarc\/#website","url":"https:\/\/www.med.unc.edu\/tarc\/","name":"Thurston Arthritis Research Center","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/tarc\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.med.unc.edu\/tarc\/#\/schema\/person\/5f08e147937c7b82481f64ec6356282f","name":"amiha","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.med.unc.edu\/tarc\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/626d87df4021821337bb351756e1167bff4bec890dfd0e5ba912b58f73a6c959?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/626d87df4021821337bb351756e1167bff4bec890dfd0e5ba912b58f73a6c959?s=96&d=mm&r=g","caption":"amiha"},"url":"https:\/\/www.med.unc.edu\/tarc\/author\/amiha\/"}]}},"featured_image":"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq.png","featured_image_medium":"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq-296x300.png","featured_image_medium_large":"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq.png","featured_image_large":"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq.png","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2024\/07\/TOPS-rtsq-150x150.png","featured_image_alt":"graphic","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/tarc\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/tarc\/wp-json\/wp\/v2\/posts\/16042","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/tarc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/tarc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/tarc\/wp-json\/wp\/v2\/users\/114753"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/tarc\/wp-json\/wp\/v2\/comments?post=16042"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/tarc\/wp-json\/wp\/v2\/posts\/16042\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/tarc\/wp-json\/wp\/v2\/media\/16051"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/tarc\/wp-json\/wp\/v2\/media?parent=16042"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/tarc\/wp-json\/wp\/v2\/categories?post=16042"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/tarc\/wp-json\/wp\/v2\/tags?post=16042"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}