{"id":3684,"date":"2017-01-26T18:35:00","date_gmt":"2017-01-26T23:35:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/tarc\/doug-phanstiel-phd-receives-grant-to-research-dna-looping-related-to-inflammation-and-immune-response\/"},"modified":"2018-08-09T09:42:50","modified_gmt":"2018-08-09T13:42:50","slug":"doug-phanstiel-phd-receives-grant-to-research-dna-looping-related-to-inflammation-and-immune-response","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/tarc\/doug-phanstiel-phd-receives-grant-to-research-dna-looping-related-to-inflammation-and-immune-response\/","title":{"rendered":"Doug Phanstiel, PhD, Receives Grant to Research DNA Looping Related to Inflammation and Immune Response"},"content":{"rendered":"<div>\n<p class=\"lead\">Thurston Arthritis Research Center scientist Doug Phanstiel, PhD, has received a three-year \u201cIndependence Award\u201d grant from the National Human Genome Research Institute at the NIH. The research he will conduct under this grant is designed to help scientists better understand a variety of biological processes that play key roles in regulating immune cell development, including DNA looping and regulation of transcription.<\/p>\n<div class=\"image-section\">\n<figure class=\"thumbnail wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium size-full wp-image-3685\" src=\"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2018\/07\/doug-phanstiel-phd-receives-grant-to-research-dna-looping-related-to-inflammation-and-immune-response-image2.jpeg\" alt=\"image2\" width=\"300\" height=\"200\" \/><figcaption class=\"caption wp-caption-text\">Doug Phanstiel, PhD<\/figcaption><\/figure>\n<\/div>\n<p>Genes make up less than two percent of the human genome. Scattered throughout the rest of the genome (the complete set of genetic instructions for an organism) are areas that regulate the expression of genes \u2013 the process by which genetic instructions are used to create products such as proteins. Large DNA \u201cloops\u201d bring these regions into close proximity with the genes they are meant to target. These loops play a major role in regulating human development, health, and disease. Unfortunately, high-throughput and accurate methods to detect and study DNA loops are still emerging. The research covered by this grant will involve developing new tools to identify DNA loops, and provide new insights into the role that looping plays related to immune response and inflammation. Because altered, or incorrect, regulation of transcription is a common cause for many human diseases, this work is likely to inform our understanding of a variety of biological processes and human disease states.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>Thurston Arthritis Research Center scientist Doug Phanstiel, PhD, has received a three-year &#8220;Independence Award&#8221; grant from the National Human Genome Research Institute at the NIH.  The research he will conduct under this grant is designed to help scientists better understand a variety of biological processes that play key roles in regulating immune cell development, including DNA looping and regulation of transcription.<\/p>\n","protected":false},"author":58060,"featured_media":3685,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-3684","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Doug Phanstiel, PhD, Receives Grant to Research DNA Looping Related to Inflammation and Immune Response | Thurston Arthritis Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/tarc\/doug-phanstiel-phd-receives-grant-to-research-dna-looping-related-to-inflammation-and-immune-response\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Doug Phanstiel, PhD, Receives Grant to Research DNA Looping Related to Inflammation and Immune Response | Thurston Arthritis Research Center\" \/>\n<meta property=\"og:description\" content=\"Thurston Arthritis Research Center scientist Doug Phanstiel, PhD, has received a three-year &quot;Independence Award&quot; grant from the National Human Genome Research Institute at the NIH. The research he will conduct under this grant is designed to help scientists better understand a variety of biological processes that play key roles in regulating immune cell development, including DNA looping and regulation of transcription.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/tarc\/doug-phanstiel-phd-receives-grant-to-research-dna-looping-related-to-inflammation-and-immune-response\/\" \/>\n<meta property=\"og:site_name\" content=\"Thurston Arthritis Research Center\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/unctarc\" \/>\n<meta property=\"article:published_time\" content=\"2017-01-26T23:35:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-08-09T13:42:50+00:00\" \/>\n<meta property=\"og:image\" 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