{"id":3864,"date":"2016-02-18T15:50:00","date_gmt":"2016-02-18T20:50:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/tarc\/thurston-arthritis-research-center-scientists-shed-new-light-on-a-specific-mechanism-involved-with-lupus-2\/"},"modified":"2018-08-09T09:43:40","modified_gmt":"2018-08-09T13:43:40","slug":"thurston-arthritis-research-center-scientists-shed-new-light-on-a-specific-mechanism-involved-with-lupus-2","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/tarc\/thurston-arthritis-research-center-scientists-shed-new-light-on-a-specific-mechanism-involved-with-lupus-2\/","title":{"rendered":"Thurston Arthritis Research Center scientists shed new light on a specific mechanism involved with lupus"},"content":{"rendered":"<div>\n<p class=\"lead\">This research is the first to clearly identify and illuminate a specific mechanism of action involved in lupus. Funding from the Lupus Research Institute is helping pave the way for additional research, and TARC has begun enrolling patients for a clinical trial designed provide additional insights into this disease.<\/p>\n<div class=\"image-section\">\n<figure class=\"thumbnail wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3817\" src=\"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2018\/07\/thurston-arthritis-research-center-scientists-shed-new-light-on-a-specific-mechanism-involved-with-lupus-image2-300x225.jpeg\" alt=\"image2\" width=\"300\" height=\"200\" \/><figcaption class=\"caption wp-caption-text\">Barbara Vilen, PhD; and Jennifer Rogers, MD<\/figcaption><\/figure>\n<\/div>\n<div>\n<p>Researchers at the Thurston Arthritis Research Center (TARC) at UNC have obtained critical new insights into some of the biological mechanisms that cause lupus. And now, funding received from the Lupus Research Institute promises to help them continue advancing basic and clinical research that may help enable the development of new drugs in the future.<\/p>\n<p>Lupus, an often debilitating autoimmune disease, results from the human body mistakenly attacking healthy cells and thereby damaging patients\u2019 tissues and organs. Exactly how this happens is not well understood, but one key aspect of this process is now clearer, thanks to the work of researchers at TARC.<\/p>\n<p>\u201cIn all individuals, cells and tissues naturally die off and need to be removed from the body,\u201d says Barbara Vilen, PhD, and Associate Professor of Microbiology &amp; Immunology. \u201cThis clearing process is performed by a biological structure within the cell called a lysosome. We have learned that in people with lupus, the activity of the lysosomes may be impaired in very specific ways. As a consequence the person\u2019s body accumulates cellular waste that is not properly removed, causing their immune systems to produce auto-antibodies (proteins that attack the body\u2019s cells), which leads to damage of healthy tissues.\u201d In essence, the body mistakes the remaining cellular waste as foreign invaders and goes on the attack.<\/p>\n<p>Jennifer Rogers, MD, a rheumatologist and assistant professor of medicine, adds that extensive laboratory research performed at TARC is now being validated in human patients, and it is shedding new light on what\u2019s happening with patients who have lupus. The research center has begun enrolling patients for a cross-sectional and longitudinal clinical trial to gain additional insights among people with high and low levels of disease activity.<\/p>\n<p>\u201cWhat impedes drug development for the effective treatment of lupus is the ability to identify the underlying pathways that lead to improper activation of the immune system,\u201d says Vilen. \u201cOur research has now identified one of the key pathways involved with the body\u2019s inability to degrade and clear cellular debris, which helps us better understand what mechanisms activate the immune system. This is the first research to clearly identify and illuminate this specific mechanism of action.\u201d<\/p>\n<p>While the research being performed at TARC is just one piece of the puzzle when it comes to finding ways to combat lupus, it\u2019s a good example of how the research center is combining strong laboratory and clinical expertise to provide the greatest opportunity to find ways to help patients in the future.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p><!-- description --> <\/p>\n<p class='lead'>This research is the first to clearly identify and illuminate a specific mechanism of action involved in lupus. Funding from the Lupus Research Institute is helping pave the way for additional research, and TARC has begun enrolling patients for a clinical trial designed provide additional insights into this disease.<\/p>\n","protected":false},"author":58060,"featured_media":3817,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[4],"class_list":["post-3864","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-research-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Thurston Arthritis Research Center scientists shed new light on a specific mechanism involved with lupus | Thurston Arthritis Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/tarc\/thurston-arthritis-research-center-scientists-shed-new-light-on-a-specific-mechanism-involved-with-lupus-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Thurston Arthritis Research Center scientists shed new light on a specific mechanism involved with lupus | Thurston Arthritis Research Center\" \/>\n<meta property=\"og:description\" content=\"This research is the first to clearly identify and illuminate a specific mechanism of action involved in lupus. Funding from the Lupus Research Institute is helping pave the way for additional research, and TARC has begun enrolling patients for a clinical trial designed provide additional insights into this disease.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/tarc\/thurston-arthritis-research-center-scientists-shed-new-light-on-a-specific-mechanism-involved-with-lupus-2\/\" \/>\n<meta property=\"og:site_name\" content=\"Thurston Arthritis Research Center\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/unctarc\" \/>\n<meta property=\"article:published_time\" content=\"2016-02-18T20:50:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-08-09T13:43:40+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2018\/07\/thurston-arthritis-research-center-scientists-shed-new-light-on-a-specific-mechanism-involved-with-lupus-image2.jpeg\" \/>\n\t<meta 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