{"id":8832,"date":"2020-03-03T10:58:32","date_gmt":"2020-03-03T15:58:32","guid":{"rendered":"https:\/\/www.med.unc.edu\/tarc\/?p=8832"},"modified":"2020-03-03T11:44:30","modified_gmt":"2020-03-03T16:44:30","slug":"nih-phase-iii-small-business-innovation-research-grant-awarded-to-epicypher-and-drs-saira-sheikh-nigel-key-for-development-of-novel-biomarkers-of-autoimmune-diseases","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/tarc\/nih-phase-iii-small-business-innovation-research-grant-awarded-to-epicypher-and-drs-saira-sheikh-nigel-key-for-development-of-novel-biomarkers-of-autoimmune-diseases\/","title":{"rendered":"NIH Phase II Small Business Innovation Research Grant Awarded to EpiCypher\u00ae, and Drs. Saira Sheikh &amp; Nigel Key to Develop Novel Biomarkers of Autoimmune Diseases"},"content":{"rendered":"<p><a href=\"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2020\/03\/Combo-2-dr-sheikh-and-dr-key-nrw.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-8838\" src=\"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2020\/03\/Combo-2-dr-sheikh-and-dr-key-nrw-300x221.png\" alt=\"\" width=\"300\" height=\"221\" srcset=\"https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2020\/03\/Combo-2-dr-sheikh-and-dr-key-nrw-300x221.png 300w, https:\/\/www.med.unc.edu\/tarc\/wp-content\/uploads\/sites\/802\/2020\/03\/Combo-2-dr-sheikh-and-dr-key-nrw.png 571w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a>Dr. Saira Sheikh of the UNC Thurston Arthritis Research Center and Dr. Nigel Key of the UNC Blood Research Center partnered with local biotech company EpiCypher\u00ae for the successful Grant, funded by NIAID. The total award to EpiCypher\u00ae is $3 million dollars over three years, with just under a $1 million sub-award to UNC.<\/p>\n<p>Dr. Sheikh, who is Principal Investigator of the projects at UNC, has also worked with EpiCypher\u00ae to successfully complete two Phase I NIH Small Business Innovation Research Grants.<\/p>\n<p>Together, their team is developing and commercializing a novel blood-based assay that can be used to study and\/or diagnose a range of diseases, from rheumatoid arthritis and lupus to cancer-associated venous thromboembolism. The release of citrullinated nucleosomes into the blood is a promising biomarker that may correlate with disease activity in several autoimmune diseases (e.g. rheumatoid arthritis and lupus), making it a promising blood-accessible biomarker. However, there are no assays capable of reliably quantifying citrullinated nucleosomes in serum or plasma. EpiCypher\u2019s\u00ae innovative assay CitNuc\u2122 uses nucleosome-validated antibodies and recombinant designer nucleosome (Cit-dNuc) calibrators to accurately quantify citrullinated nucleosomes directly from human plasma\/serum.<\/p>\n<p>This work will result in the commercial launch of a quantitative research and biomarker discovery tool for autoimmune diseases as well as clinical validation studies to determine its suitability for diagnostic purposes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Saira Sheikh of the UNC Thurston Arthritis Research Center and Dr. Nigel Key of the UNC Blood Research Center partnered with local biotech company EpiCypher\u00ae for the successful Grant, funded by NIAID.<\/p>\n","protected":false},"author":58060,"featured_media":8838,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-8832","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NIH Phase II Small Business Innovation Research Grant Awarded to EpiCypher\u00ae, and Drs. Saira Sheikh &amp; Nigel Key to Develop Novel Biomarkers of Autoimmune Diseases | Thurston Arthritis Research Center<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/tarc\/nih-phase-iii-small-business-innovation-research-grant-awarded-to-epicypher-and-drs-saira-sheikh-nigel-key-for-development-of-novel-biomarkers-of-autoimmune-diseases\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NIH Phase II Small Business Innovation Research Grant Awarded to EpiCypher\u00ae, and Drs. 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