Curriculum Member Profiles
Molecular carcinogenesis: cancer, chromatin, transcription, and epigenetics
Cardiovascular biology, cell biology, drug delivery, nanomedicine, translational medicine
Validate novel molecular targets (ex. oncogenic PIM kinases) for potential therapeutic intervention in pancreatic cancer and other cancers as well as test novel PIM kinase inhibitors in combination with chemotherapy.
Pharmacokinetic behavior of environmental chemicals, mechanisms of action of toxicants including endocrine disruptors, and linking of real-world exposures to health effects
Hepatobiliary xenobiotic disposition, hepatotoxicity and pharmacokinetics
Adaptive and innate immune dysfunction after trauma
Cell Biology, Genomics, Molecular Biology, Systems Biology, Toxicology
Pharmacokinetics and mechanisms of chemical-mediated toxicity and carcinogenicity
Pulmonary toxicology and molecular biology
Environmental impacts on human health, genetic susceptibility, immunology, epigenetics, translational research
Mechanisms of health effects of environmental pollution on cardiopulmonary function, animal models of cardiovascular diseases, targeted and high throughput technology
Epidermal growth factor receptor and its ligands and signaling mechanisms of endocrine disrupting toxicants in the mammary gland
Toxicology and Immunology
Mechanisms of induction and regulation of the innate immune response, with a focus on Toll like Receptors (TLRs).
Toxicogenomic and systems biology approaches to understanding the mechanisms of metal-induced disease and the basis for inter-individual disease susceptibility
The interaction between air pollutant exposure and the development of infectious and allergic lung disease
Chemistry of protein and DNA adducts
Role of microglia in immune-mediated responses in brain development, repair, aging and disease
Neurophysiological mechanisms mediating cardiopulmonary dysfunction due to air pollution exposure.
Testing therapeutic interventions against pollutant-induced inflammation.
Mechanisms by which air pollutants enhance susceptibility to and the severity of respiratory virus infections
Gene-environment Interactions in Airway Diseases
Genetic determinants of environmental lung diseases
Cardiovascular disease and susceptibility, air pollutants, cardiopulmonary interactions, molecular mechanisms, genetic and environmental factors
Mouse models for human disease, genes that modify disease progression
The use of in vitro cell-based hepatic culture models to investigate mechanisms of compound-induced hepatotoxicity.
Metabolomics, tissue engineering and systems biology
Mechanisms of ambient air pollutant-induced cardiopulmonary morbidity and mortality
Immunology, Pathogenesis & Infection, Pathology, Toxicology, Translational Medicine
Molecular and mechanistic toxicology, primary and organotypic in vitro models, live cell imaging/fluorescent biosensors, redox dysfunction/oxidative stress, inhalation toxicology, translational research, in vitro to in vivo extrapolation, environmental and public health epigenetics
Neurotoxicology and excitotoxicity of alcohol
Pharmacogenetics of detoxification pathways in skin and inhalation exposures to toxicants; mathematical and statistical exposure modeling for risk assessment
Translational and clinical research in environmental lung disease
Mechanisms of chromosome strand break repair
Airway epithelial cell biology, pulmonary innate immunity and transplant pathophysiology
Cell and molecular mechanisms of inflammatory responses induced by inhalation of ambient air pollutants
Biochemical mechanisms of nucleotide excision repair, DNA damage cell cycle checkpoints, and circadian rhythm
Metabolic interactions of essential microelements, especially trace metals, with toxic metals and metalloids that contaminate food and drinking water
Cardiovascular and pulmonary effects of environmental pollutants, dietary interventional strategies to mitigate the health effects of air pollution exposure
Biomolecular informatics; molecular structure-function modeling using statistical and machine learning approaches
Control mechanisms of DNA replication during normal passage through an unperturbed cell cycle and in response to DNA-damaging agents
Dr. Cavin Ward-Caviness uses high-dimensional ‘omics data and large cohorts to study two major research themes: 1) determination of the molecular mechanisms linking environmental exposures and adverse health and 2) identification of molecular and clinical factors which may increase sensitivity to environmental exposures.
Mechanistic toxicology, hepatic toxicology, research translation, biomarkers
Chromatin remodeling and epigenetic alterations in human cancers
Basic reproductive biology of early mammalian embryogenesis, epigenetics, and how the environment impacts reproduction.