Institution: University of North Carolina School of Medicine
Voice: (919) 966-3522
The focus of my research group is the tumorigenesis of renal cell carcinoma. Our approach utilizes genetically engineered cells expressing clinically important point mutations in genes identified from renal cancers. Using cellular and animal models we are able to investigate processes integral to tumorigenesis including angiogenesis, hypoxic response signaling, extracellular matrix remodeling, and cell cycle signaling. Using data from the experimental models, I oversee a clinical research program that offers biologically active protocols to patients with renal cell carcinoma and examines correlative radiographic and serum or tumor biomarkers of tumor response to treatment.