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Immunology, Toxicology

Institution: U.S. Environmental Protection Agency


Voice: (919) 966-0665


Our laboratory is focused on the cellular and molecular mechanisms that control inflammatory and adaptive responses induced by inhalation of ambient air pollutants. Projects focus on early events that result in the disregulation of signaling processes that regulate gene expression, specifically oxidative effects that disrupt signaling quiescence in human lung cells. Approaches include live-cell imaging of human lung cells exposed in vitro and ex-vivo and characterization of oxidative protein modifications.