{"id":3713,"date":"2019-10-10T14:53:50","date_gmt":"2019-10-10T18:53:50","guid":{"rendered":"https:\/\/www.med.unc.edu\/toxicology\/?post_type=directory&#038;p=3713"},"modified":"2023-09-06T14:54:13","modified_gmt":"2023-09-06T18:54:13","slug":"ken-pearce","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/toxicology\/directory\/ken-pearce\/","title":{"rendered":"Ken Pearce"},"content":{"rendered":"<p><strong>Institution:<\/strong><\/p>\n<p><a href=\"https:\/\/pharmacy.unc.edu\/\">UNC Eshelman School of Pharmacy<\/a><\/p>\n<p><strong>About:<\/strong><\/p>\n<p>We are a comprehensive, collaborative group with a primary focus on lead and early drug discovery for oncology and epigenetic targets and pathways.\u00a0 Our research applies reagent production, primary assay development, high-throughput screening, biophysics, and exploratory cell biology to enable small molecule drug discovery programs in solid partnership with collaborators, both within the Center for Integrative Chemical Biology and Drug Discovery and across the UNC campus.\u00a0 We apply small molecule hit discovery to highly validated biochemical targets as well as phenotypic cell-based assays.\u00a0 Our methods include various fluorescence-based readouts and high content microscopy.\u00a0 Examples of some of our collaborative small molecule discovery programs include, inhibition of chromatin methyl-lysine reader proteins, hit discovery for small GTPases such as K-Ras and Gaq, inhibitors of inositol phosphate kinases, inhibitors of protein-protein interactions involving CIB1 and MAGE proteins, and several cell-based efforts including a screen for compounds that enhance c-Myc degradation in pancreatic cancer cells.\u00a0 In addition, we are developing a DNA-encoded library approach for hit discovery to complement traditional high-throughput screening.\u00a0 Our ultimate goal is discovery of new chemical probes and medicines for exploratory biology and unmet medical needs, respectively.<\/p>\n<p><a href=\"https:\/\/pharmacy.unc.edu\/directory\/khpearce\/\"><strong>Website<\/strong><\/a><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=pearce+kh+OR+%28pearce+k+AND+topham%29+OR+%28pearce+k+AND+ishmael%29\"><strong>Publications<\/strong><\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Institution: UNC Eshelman School of Pharmacy About: We are a comprehensive, collaborative group with a primary focus on lead and early drug discovery for oncology and epigenetic targets and pathways.\u00a0 Our research applies reagent production, primary assay development, high-throughput screening, biophysics, and exploratory cell biology to enable small molecule drug discovery programs in solid partnership &hellip; <a href=\"https:\/\/www.med.unc.edu\/toxicology\/directory\/ken-pearce\/\" aria-label=\"Read more about Ken Pearce\">Read more<\/a><\/p>\n","protected":false},"featured_media":3716,"template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"class_list":["post-3713","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"_upd_display_name":["Ken Pearce"],"_upd_reverse_display_name":["Pearce, Ken"],"_upd_last_name":["Pearce"],"_upd_first_name":["Ken"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Office:<\/strong> 3203 Marsico Hall <strong>| Phone:<\/strong> (919) 843-8461 <strong>| <a href=\"mailto:khpearce@unc.edu\">Email<\/a><\/strong>\r\n\r\nPrime Focus: Biochemistry, Biophysics, Cell Biology, Chemical Biology, Drug Discovery."],"_upd_no_link":[],"_upd_degree1":["PhD"],"_upd_degree2":[],"_upd_email":[[{"email_text":"khpearce@unc.edu"}]],"_upd_phone":[[{"phone_text":"(919) 843-8461","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"3203 Marsico Hall","address-2":"","campus-box":"","city":"Chapel Hill","state":"NC","zip":"27599"}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/directory\/3713","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/directory\/3713\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/media\/3716"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/media?parent=3713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}