{"id":4022,"date":"2020-12-11T12:27:59","date_gmt":"2020-12-11T17:27:59","guid":{"rendered":"https:\/\/www.med.unc.edu\/toxicology\/?post_type=directory&#038;p=4022"},"modified":"2023-09-06T15:03:22","modified_gmt":"2023-09-06T19:03:22","slug":"imran-rizvi","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/toxicology\/directory\/imran-rizvi\/","title":{"rendered":"Imran Rizvi"},"content":{"rendered":"<p><strong>Institutions:<\/strong><\/p>\n<p><a href=\"https:\/\/www.unc.edu\/\">University of North Carolina at Chapel Hill<\/a><\/p>\n<p><a href=\"https:\/\/www.ncsu.edu\/\">North Carolina State University<\/a><\/p>\n<p><strong>About:<\/strong><\/p>\n<p>Research in the Rizvi lab focuses on identifying, and photochemically targeting, sources of treatment failure in cancer with an emphasis on the following key areas: 1.) Iterative and collaborative development of physiologically-relevant <em>in vitro<\/em> and <em>in vivo<\/em> tumor models. The focus is to integrate principles from engineering and cancer biology to develop technologies designed to elucidate sources of treatment resistance; 2.) Identification of molecular survival pathways that are modulated by external cues such as flow-induced shear stress, and more recently environmental contaminants, as determinants of chemoresistance in ovarian cancer; 3.) Development of optically-triggered and imaging-informed targeted combination therapies to maximize potency with minimal off-target toxicity. The design of these combinations is based on the mechanistically-distinct cytotoxicity conferred by photodynamic therapy (PDT), the core light-triggered modality, and the ability of PDT to reverse chemoresistance, synergize with chemotherapeutics and biologics, and overcome compensatory survival pathways.<\/p>\n<p><strong><a href=\"https:\/\/bme.unc.edu\/peoples\/imran-rizvi\/\">Website<\/a><\/strong><\/p>\n<p><strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/14WCnny2GumUya\/bibliography\/public\/\">Publications<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Institutions: University of North Carolina at Chapel Hill North Carolina State University About: Research in the Rizvi lab focuses on identifying, and photochemically targeting, sources of treatment failure in cancer with an emphasis on the following key areas: 1.) Iterative and collaborative development of physiologically-relevant in vitro and in vivo tumor models. The focus is &hellip; <a href=\"https:\/\/www.med.unc.edu\/toxicology\/directory\/imran-rizvi\/\" aria-label=\"Read more about Imran Rizvi\">Read more<\/a><\/p>\n","protected":false},"featured_media":4024,"template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"class_list":["post-4022","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"_upd_display_name":["Imran Rizvi"],"_upd_reverse_display_name":["Rizvi, Imran"],"_upd_last_name":["Rizvi"],"_upd_first_name":["Imran"],"_upd_sortorder_override":[],"_upd_sortorder":["1"],"_upd_gallery_summary":["<strong>Office:<\/strong> 9206C Mary Ellen Jones Building <strong>| Phone:<\/strong> (919) 966-4934 <strong>| <a href=\"mailto:imran.rizvi@unc.edu\">Email<\/a><\/strong>\r\n\r\nPrime Focus: Biomedical Imaging, Rehabilitation Engineering.\r\n\r\n&nbsp;"],"_upd_no_link":[],"_upd_degree1":[],"_upd_degree2":[],"_upd_email":[[{"email_text":"imran.rizvi@unc.edu"}]],"_upd_phone":[[{"phone_text":"(919) 966-4934","phone_type":"Office Phone"}]],"_upd_address":[[{"address":{"address-1":"9206C Mary Ellen Jones Bldg","address-2":"","campus-box":"CB # 7575","city":"Chapel Hill","state":"NC","zip":""}}]],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/directory\/4022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/directory"}],"about":[{"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/types\/directory"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/directory\/4022\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/media\/4024"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/media?parent=4022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}