{"id":4894,"date":"2024-06-24T14:45:16","date_gmt":"2024-06-24T18:45:16","guid":{"rendered":"https:\/\/www.med.unc.edu\/toxicology\/?post_type=directory&#038;p=4894"},"modified":"2024-06-24T14:45:16","modified_gmt":"2024-06-24T18:45:16","slug":"matthew-redinbo","status":"publish","type":"directory","link":"https:\/\/www.med.unc.edu\/toxicology\/directory\/matthew-redinbo\/","title":{"rendered":"Matthew Redinbo"},"content":{"rendered":"<div class=\"directory-post-excerpt\">\n<p class=\"lead\">Research: Drug Discovery and the Gut Microbiome<\/p>\n<\/div>\n<div class=\"directory-profile single \">\n<div class=\"directory-post-content\">\n<p>&nbsp;<\/p>\n<p><em><strong><span class=\"blue\">Professor of Chemistry, UNC-CH<\/span><\/strong><\/em><\/p>\n<p>Professor of Biochemistry and Biophysics<br \/>\nProfessor of Microbiology and Immunology<br \/>\nDirector of Structural Biology<br \/>\nMember of Program in Molecular Biology and Biotechnology<br \/>\nMember of the Lineberger Comprehensive Cancer Center<\/p>\n<p>PhD \u2013 University of California, Los Angeles<\/p>\n<p class=\" \"><span class=\"btn btn-large btn-blue xxLargeFont normalSizeFont smallFont\">ACCEPTING STUDENTS<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-10603 size-thumbnail\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/08\/Faculty-OGE-Trained-mentor-badge-400dpi-for-website-150x150.png\" alt=\"Trained Faculty Mentor endorsed by Office of Graduate Ed UNC Chapel Hill\" width=\"150\" height=\"150\" \/><\/p>\n<div>\n<h3><span class=\"blue\"><span class=\"largeFont\">HONORS &amp; AWARDS<\/span><\/span><\/h3>\n<ul>\n<li>UNC Tanner Award for Excellence in Undergraduate teaching, 2019<\/li>\n<li>UNC Research Outstanding Mentor Award, 2018<\/li>\n<li>Fellow, AAAS, 2013<\/li>\n<li>Academic Leadership Fellow, UNC, 2011<\/li>\n<li>Academic Leadership Fellow, 2010<\/li>\n<li>Phillip and Ruth Hettleman Prize for Artistic and Scholarly Achievement, 2004<\/li>\n<li>Burroughs Wellcome Career Award in the Biomedical Sciences, 1999<\/li>\n<\/ul>\n<h3><span class=\"blue\">RESEARCH<\/span><\/h3>\n<p>Summary:<\/p>\n<p>The focus of the Redinbo Lab is the examination of the structural and functional basis of cellular function with an eye toward human health. Current projects include discovery and development of drugs that improve chemotherapeutic efficacy for cancer and other diseases, and elucidation of the mechanisms of antibiotic resistance propagation in infectious pathogens. Basic science goals include understanding DNA manipulation and processing, transcription, and protein function during infection and disease.<\/p>\n<p>Core Techniques:<\/p>\n<p>Structural biology, chemical biology, biochemistry, molecular biology, microbiology, cell biology, drug discovery.<\/p>\n<h3><span class=\"blue\">SELECTED PUBLICATIONS<br \/>\n<\/span><span class=\"normalSizeFont\"><span class=\"discreet\"><a class=\"external-link\" title=\"\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?cmd=PureSearch&amp;term=redinbo+mr\" target=\"_self\" rel=\"noopener noreferrer\"><img loading=\"lazy\" decoding=\"async\" class=\"image-inline\" title=\"pubmed.png\" src=\"https:\/\/www.med.unc.edu\/biochem\/wp-content\/uploads\/sites\/795\/2019\/03\/pubmed.png\" alt=\"PubMed\" width=\"82\" height=\"33\" \/><\/a>(click<\/span><\/span><span class=\"discreet\">for Full Publication List)<\/span><\/h3>\n<h4>2022<\/h4>\n<ul>\n<li class=\"sqsrte-small\">Simpson JB, Redinbo MR. Multi-omic analysis of host-microbial interactions central to the gut-brain axis. Mol Omics. 2022 Dec 5;18(10):896-907. doi: 10.1039\/d2mo00205a. PMID: 36169030.<\/li>\n<li class=\"sqsrte-small\">Simpson JB, Sekela JJ, Graboski AL, Borlandelli VB, Bivins MM, Barker NK, Sorgen AA, Mordant AL, Johnson RL, Bhatt AP, Fodor AA, Herring LE, Overkleeft H, Lee JR, Redinbo MR. Metagenomics combined with activity-based proteomics point to gut bacterial enzymes that reactivate mycophenolate. Gut Microbes. 2022 Jan-Dec;14(1):2107289. doi: 10.1080\/19490976.2022.2107289. PMID: 35953888; PMCID: PMC9377255.<\/li>\n<li class=\"sqsrte-small\">Conway JM, Walton WG, Salas-Gonz\u00e1lez I, Law TF, Lindberg CA, Crook LE, Kosina SM, Fitzpatrick CR, Lietzan AD, Northen TR, Jones CD, Finkel OM, Redinbo MR, and Dangl JL. Diverse MarR bacterial regulators of auxin catabolism in the plant microbiome.\u00a0<em>Nat Microbiol<\/em>\u00a07, 1817\u20131833 (2022). https:\/\/doi.org\/10.1038\/s41564-022-01244-3<\/li>\n<li class=\"sqsrte-small\">Edwinson AL, Yang L, Peters S, Hanning N, Jeraldo P, Jagtap P, Simpson JB, Yang TY, Kumar P, Mehta S, Nair A, Breen-Lyles M, Chikkamenahalli L, Graham RP, De Winter B, Patel R, Dasari S, Kashyap P, Griffin T, Chen J, Farrugia G, Redinbo MR, Grover M. Gut microbial \u03b2-glucuronidases regulate host luminal proteases and are depleted in irritable bowel syndrome. Nat Microbiol. 2022 May;7(5):680-694. doi: 10.1038\/s41564-022-01103-1. Epub 2022 Apr 28. PMID: 35484230; PMCID: PMC9081267.<\/li>\n<li class=\"sqsrte-small\">Zhang J, Walker ME, Sanidad KZ, Zhang H, Liang Y, Zhao E, Chacon-Vargas K, Yeliseyev V, Parsonnet J, Haggerty TD, Wang G, Simpson J, Jariwala P, Beaty V, Yang J, Yang H, Panigrahy A, Minter L, Kim D, Gibbons J, Liu L, Li Z, Xiao H, Borlandelli V, Overkleeft H, Cloer E, Major M, Goldfarb D, Cai Z, Redinbo MR, Zhang G. Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.\u00a0<em>Nat Commun<\/em>\u00a013, 136 (2022). https:\/\/doi.org\/10.1038\/s41467-021-27762-y<\/li>\n<\/ul>\n<div>\n<hr \/>\n<\/div>\n<h3><span class=\"blue\">Lab Contact:<\/span><\/h3>\n<div>Lab Rooms: Genome Sciences 4350<\/div>\n<div>Lab Fax: 919-962-2388<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Research: Drug Discovery and the Gut Microbiome &nbsp; Professor of Chemistry, UNC-CH Professor of Biochemistry and Biophysics Professor of Microbiology and Immunology Director of Structural Biology Member of Program in Molecular Biology and Biotechnology Member of the Lineberger Comprehensive Cancer Center PhD \u2013 University of California, Los Angeles ACCEPTING STUDENTS HONORS &amp; AWARDS UNC Tanner &hellip; <a href=\"https:\/\/www.med.unc.edu\/toxicology\/directory\/matthew-redinbo\/\" aria-label=\"Read more about Matthew Redinbo\">Read more<\/a><\/p>\n","protected":false},"featured_media":4895,"template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"class_list":["post-4894","directory","type-directory","status-publish","has-post-thumbnail","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Matthew Redinbo - Curriculum in Toxicology &amp; 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