{"id":2325,"date":"2016-03-03T20:05:00","date_gmt":"2016-03-04T01:05:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/toxicology\/about-us\/member-profiles\/cairns-bruce\/"},"modified":"2019-01-15T10:16:06","modified_gmt":"2019-01-15T15:16:06","slug":"cairns-bruce","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/toxicology\/about-us\/cairns-bruce\/","title":{"rendered":"Bruce Cairns"},"content":{"rendered":"

<\/p>\n

\n

Developmental Biology, Immunology, Molecular Biology, Pathology, Physiology<\/p>\n

Institution: University of North Carolina School of Medicine<\/a><\/p>\n

Website: https:\/\/www.med.unc.edu\/microimm\/directory\/bruce-cairns\/<\/a><\/p>\n

Email: bruce_cairns@med.unc.edu<\/a><\/p>\n

Voice: (919) 966-8159<\/p>\n

The immune system of severely burned patients becomes extremely suppressed after injury. An overwhelming number of patients die from wound infection and sepsis. However, we are unable to graft these patients with skin from other donors as their immune system is still able to reject the graft efficiently. Our inability to cover the wound site leaves the patients further open to bacterial and fungal infections. Our laboratory investigates the translational immune mechanisms for these devastating consequences of burn within mouse models and burn patients. Focuses in the lab include 1) investigation of innate molecule control of both the innate and adaptive immune systems after burn injury, 2) Role of innate signaling to Damage Associated Molecular Patterns in Immune Dysfunction after burn \/ inhalational injury,focusing on mTOR-mediated Immunomodulation 3) Using NRF2\/KEAP1-Targeted Therapy to Prevent Pneumonitis and Immune Dysfunction After Radiation or Combined Burn-Radiation Injury and 4) Investigating sex-specific disparities in Immune Dysfunction after trauma \/ transplantation. \u200b<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Developmental Biology, Immunology, Molecular Biology, Pathology, Physiology Institution: University of North Carolina School of Medicine Website: https:\/\/www.med.unc.edu\/microimm\/directory\/bruce-cairns\/ Email: bruce_cairns@med.unc.edu Voice: (919) 966-8159 The immune system of severely burned patients becomes extremely suppressed after injury. An overwhelming number of patients die from wound infection and sepsis. However, we are unable to graft these patients with skin … Read more<\/a><\/p>\n","protected":false},"author":33650,"featured_media":0,"parent":2216,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2325","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"\nBruce Cairns - Curriculum in Toxicology & Environmental Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/toxicology\/about-us\/cairns-bruce\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Bruce Cairns - Curriculum in Toxicology & Environmental Medicine\" \/>\n<meta property=\"og:description\" content=\"Developmental Biology, Immunology, Molecular Biology, Pathology, Physiology Institution: University of North Carolina School of Medicine Website: https:\/\/www.med.unc.edu\/microimm\/directory\/bruce-cairns\/ Email: bruce_cairns@med.unc.edu Voice: (919) 966-8159 The immune system of severely burned patients becomes extremely suppressed after injury. 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