{"id":2402,"date":"2012-02-14T13:45:00","date_gmt":"2012-02-14T18:45:00","guid":{"rendered":"https:\/\/www.med.unc.edu\/toxicology\/about-us\/member-profiles\/swenberg\/"},"modified":"2018-06-14T13:39:48","modified_gmt":"2018-06-14T17:39:48","slug":"swenberg","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/toxicology\/about-us\/swenberg\/","title":{"rendered":"James Swenberg"},"content":{"rendered":"

<\/p>\n

Mechanisms of DNA damage and repair; molecular epidemiology; development of ultra-sensitive and specific methods for measuring chemical adducts in DNA and hemoglobin<\/p>\n

\n

Institution: University of North Carolina Gillings School of Global Public Health<\/a><\/p>\n

Website: http:\/\/www.sph.unc.edu\/?option=com_profiles&Itemid=1891&profileAction=ProfDetail&pid=704283985<\/a><\/p>\n

Email: james_swenberg@unc.edu<\/a><\/p>\n

Voice: (919) 966-6139<\/p>\n

Publications<\/a><\/p>\n

My laboratory focuses on understanding mechanisms of carcinogenesis, with emphasis on the role of DNA damage and repair. During the last few years, we have developed ultra-sensitive and highly specific mass spectrometry methods for measuring the DNA and hemoglobin adducts of vinyl chloride, crotonaldehyde, ethylene oxide, propylene oxide, styrene oxide, butadiene, malondialdehyde, cis-platin and O6-methyldeoxy-guanosine, as well as slotblot methods for AP sites and oxidative DNA damage. These methods have been applied to understanding critical mechanisms in carcinogenesis, as well as undertaking molecular epidemiology studies of workers in the butadiene and reinforced plastics industries. We are also examining changes in gene expression associated with oxidative stress and environmental chemical exposure.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Mechanisms of DNA damage and repair; molecular epidemiology; development of ultra-sensitive and specific methods for measuring chemical adducts in DNA and hemoglobin Institution: University of North Carolina Gillings School of Global Public Health Website: http:\/\/www.sph.unc.edu\/?option=com_profiles&Itemid=1891&profileAction=ProfDetail&pid=704283985 Email: james_swenberg@unc.edu Voice: (919) 966-6139 Publications My laboratory focuses on understanding mechanisms of carcinogenesis, with emphasis on the role of … Read more<\/a><\/p>\n","protected":false},"author":315,"featured_media":0,"parent":2216,"menu_order":53,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2402","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"\nJames Swenberg - Curriculum in Toxicology & Environmental Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/toxicology\/about-us\/swenberg\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"James Swenberg - Curriculum in Toxicology & Environmental Medicine\" \/>\n<meta property=\"og:description\" content=\"Mechanisms of DNA damage and repair; molecular epidemiology; development of ultra-sensitive and specific methods for measuring chemical adducts in DNA and hemoglobin Institution: University of North Carolina Gillings School of Global Public Health Website: http:\/\/www.sph.unc.edu\/?option=com_profiles&Itemid=1891&profileAction=ProfDetail&pid=704283985 Email: james_swenberg@unc.edu Voice: (919) 966-6139 Publications My laboratory focuses on understanding mechanisms of carcinogenesis, with emphasis on the role of … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/toxicology\/about-us\/swenberg\/\" \/>\n<meta property=\"og:site_name\" content=\"Curriculum in Toxicology & Environmental Medicine\" \/>\n<meta property=\"article:modified_time\" content=\"2018-06-14T17:39:48+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/toxicology\/about-us\/swenberg\/\",\"url\":\"https:\/\/www.med.unc.edu\/toxicology\/about-us\/swenberg\/\",\"name\":\"James Swenberg - Curriculum in Toxicology & Environmental Medicine\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/toxicology\/#website\"},\"datePublished\":\"2012-02-14T18:45:00+00:00\",\"dateModified\":\"2018-06-14T17:39:48+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/toxicology\/about-us\/swenberg\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/toxicology\/about-us\/swenberg\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/toxicology\/about-us\/swenberg\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/toxicology\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Private: About Us\",\"item\":\"https:\/\/www.med.unc.edu\/toxicology\/?page_id=2216\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"James Swenberg\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/toxicology\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/toxicology\/\",\"name\":\"Curriculum in Toxicology & Environmental Medicine\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/toxicology\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"James Swenberg - Curriculum in Toxicology & Environmental Medicine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/toxicology\/about-us\/swenberg\/","og_locale":"en_US","og_type":"article","og_title":"James Swenberg - Curriculum in Toxicology & Environmental Medicine","og_description":"Mechanisms of DNA damage and repair; 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