{"id":3451,"date":"2019-01-14T09:15:48","date_gmt":"2019-01-14T14:15:48","guid":{"rendered":"https:\/\/www.med.unc.edu\/toxicology\/?p=3451"},"modified":"2019-01-14T10:08:22","modified_gmt":"2019-01-14T15:08:22","slug":"dr-samantha-faber-awarded-sot-2019-colgate-palmolive-postdoc-fellowship-award-in-in-vitro-toxicology","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/toxicology\/dr-samantha-faber-awarded-sot-2019-colgate-palmolive-postdoc-fellowship-award-in-in-vitro-toxicology\/","title":{"rendered":"Dr. Samantha Faber awarded SOT 2019 Colgate-Palmolive Postdoc Fellowship Award in In-Vitro Toxicology"},"content":{"rendered":"<figure id=\"attachment_3452\" class=\"thumbnail wp-caption alignright\" style=\"width: 310px\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-3452\" src=\"https:\/\/www.med.unc.edu\/toxicology\/wp-content\/uploads\/sites\/738\/2019\/01\/Faber-pic-011419-300x200.jpg\" alt=\"Dr. Samantha Faber\" width=\"300\" height=\"200\" \/><figcaption class=\"caption wp-caption-text\">Dr. Samantha Faber, PhD<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>Postdoctoral Trainee Dr. Samantha Faber, PhD has been awarded the Society of Toxicology 2019 Colgate-Palmolive Postdoc Fellowship Award in In-Vitro Toxicology.\u00a0\u00a0 Her project title\u00a0 is &#8220;Beyond the Barrier; A Readily Adoptable <em>In Vitro<\/em> Model for Exploring the Effects of Inhaled Toxicants beyond the Epithelium&#8221;.\u00a0 Please see below for a short summary of the grant proposal.\u00a0 Congratulations to Dr. Faber!!!!<\/p>\n<p><strong>Short Summary of grant proposal:<\/strong><\/p>\n<p><span style=\"font-family: 'Helvetica',sans-serif;color: black\">The vast majority of mechanistic studies in inhalation toxicology have relied upon airway epithelial cell\u00a0monoculture models. While epithelial cells play a well-defined role in the effects of inhaled chemical exposures,\u00a0exploring the effects of these exposures on cell types that reside beneath the epithelium (i.e., stromal cells) and play\u00a0critical roles in lung structure\/function has typically required the use of <i>in vivo<\/i> animal models.\u00a0To address these challenges, we designed a novel <i>in vitro<\/i> approach to study \u2018trans-epithelial\u2019\u00a0exposures, that incorporates an <i>in vivo<\/i>-like airway epithelial barrier and physiologically-relevant exposure\u00a0parameters. Using gene expression techniques, live-cell imaging, and inhibitor studies we will identify molecules\u00a0governing key cellular signaling pathways\u00a0and define dynamics of oxidative stress\/proinflammatory\u00a0response. Ultimately, this trans-epithelial model will enable examination of inhaled toxicant exposures\u00a0within the stroma, providing accurate <i>in vitro<\/i> to <i>in vivo<\/i> extrapolation for inhalation toxicity testing.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Postdoctoral Trainee Dr. Samantha Faber, PhD has been awarded the Society of Toxicology 2019 Colgate-Palmolive Postdoc Fellowship Award in In-Vitro Toxicology.\u00a0\u00a0 Her project title\u00a0 is &#8220;Beyond the Barrier; A Readily Adoptable In Vitro Model for Exploring the Effects of Inhaled Toxicants beyond the Epithelium&#8221;.\u00a0 Please see below for a short summary of the grant &hellip; <a href=\"https:\/\/www.med.unc.edu\/toxicology\/dr-samantha-faber-awarded-sot-2019-colgate-palmolive-postdoc-fellowship-award-in-in-vitro-toxicology\/\" aria-label=\"Read more about Dr. Samantha Faber awarded SOT 2019 Colgate-Palmolive Postdoc Fellowship Award in In-Vitro Toxicology\">Read more<\/a><\/p>\n","protected":false},"author":33650,"featured_media":3452,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"class_list":["post-3451","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","odd"],"acf":[],"featured_image":"https:\/\/www.med.unc.edu\/toxicology\/wp-content\/uploads\/sites\/738\/2019\/01\/Faber-pic-011419-e1547475308209.jpg","featured_image_medium":"https:\/\/www.med.unc.edu\/toxicology\/wp-content\/uploads\/sites\/738\/2019\/01\/Faber-pic-011419-300x200.jpg","featured_image_medium_large":"https:\/\/www.med.unc.edu\/toxicology\/wp-content\/uploads\/sites\/738\/2019\/01\/Faber-pic-011419-768x512.jpg","featured_image_large":"https:\/\/www.med.unc.edu\/toxicology\/wp-content\/uploads\/sites\/738\/2019\/01\/Faber-pic-011419-1024x683.jpg","featured_image_thumbnail":"https:\/\/www.med.unc.edu\/toxicology\/wp-content\/uploads\/sites\/738\/2019\/01\/Faber-pic-011419-150x150.jpg","featured_image_alt":"Dr. Samantha Faber","category_details":[{"name":"News","link":"https:\/\/www.med.unc.edu\/toxicology\/category\/news\/"}],"tag_details":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/posts\/3451","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/users\/33650"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/comments?post=3451"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/posts\/3451\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/media\/3452"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/media?parent=3451"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/categories?post=3451"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.med.unc.edu\/toxicology\/wp-json\/wp\/v2\/tags?post=3451"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}