{"id":6475,"date":"2019-10-17T05:00:49","date_gmt":"2019-10-17T09:00:49","guid":{"rendered":"https:\/\/www.med.unc.edu\/urology\/?p=6475"},"modified":"2020-04-08T16:01:50","modified_gmt":"2020-04-08T20:01:50","slug":"funding-approved-for-pilot-analysis-of-bladder-carcinogens-in-the-urine-of-young-adult-e-cigarettes-users","status":"publish","type":"post","link":"https:\/\/www.med.unc.edu\/urology\/funding-approved-for-pilot-analysis-of-bladder-carcinogens-in-the-urine-of-young-adult-e-cigarettes-users\/","title":{"rendered":"Funding Approved For Pilot Analysis Of Bladder Carcinogens In The Urine Of Young Adult E-Cigarettes Users"},"content":{"rendered":"<p class=\"lead\">A recently approved funding proposal through NC TraCS and NYU to characterize carcinogenic biomarkers found in the urine of young adult e-cigarette users will soon be underway.<\/p>\n<p class=\"lead\">The proposal, put together by UNC Urologist <a href=\"#bjurlin\">Dr. Marc Bjurlin<\/a>, <a href=\"#jaspers\">Dr. Ilona Jaspers<\/a> (UNC Gillings School of Global Public Health), and <a href=\"#gordon\">Dr. Terry Gordon<\/a> (NYU School of Medicine), hopes to not only better understand the types of bladder cancer-causing biomarkers in e-cigarette user urine, but also strengthen the foundation for future e-cigarette research and regulations.<\/p>\n<h2>Background<\/h2>\n<p>The health consequences of e-cigarette use reach beyond the neurological or the pulmonary effects and can include damage to the urinary bladder. It is already well known that inhalation during cigarette smoking brings some of the cancer-causing chemicals in cigarettes out of the lungs and into the blood. These carcinogens are then filtered by the kidneys and deposited into the urine. As urine is held in the bladder, the carcinogens in the fluid may damage the cells on the bladder wall, increasing the risk of cancer.<\/p>\n<p>Specifically to e-cigarettes, biomarkers of toxic and carcinogenic compounds have been observed in the urine of e-cigarettes users <sup>1,2<\/sup> and exposure to these could also lead to the development of bladder cancer like observed in cigarette smokers. This may be especially true for those who have had an early introduction to e-cigarettes and chronic exposure <a href=\"https:\/\/www.chicagotribune.com\/sns-flavored-e-cigarettes-sweetly-lure-kids-into-vaping-and-also-mislead-them-to-dismiss-danger-studies-suggest-123500-20190916-story.html\">like so many teens and young adults have in recent years<\/a>.<\/p>\n<h2>A Multidisciplinary, Collaborative Approach<\/h2>\n<p>To address the health issues mentioned above, <a href=\"#bjurlin\">Drs. Bjurlin, Gordon, and Jaspers<\/a> will analyze the urine of young adult e-cigarette users for any known urinary bladder carcinogen biomarkers and compare these findings against both cigarette users and non-users.<\/p>\n<p>Their multidisciplinary teams will work in collaboration with the <a href=\"https:\/\/www.cduhr.org\/project\/center-for-alternative-tobacco-product-studies\/\">Center for Alternative Tobacco Product Studies<\/a> (an affiliate of NYU), the <a href=\"https:\/\/www.med.unc.edu\/urology\/\">UNC Department of Urology<\/a>, the <a href=\"https:\/\/www.med.unc.edu\/cemalb\/\">UNC Center for Environmental Medicine, Asthma and Lung Biology<\/a>, and the Biomarkers Mass Spectrometry sub-core of the <a href=\"https:\/\/sph.unc.edu\/cehs\/center-for-environmental-health-and-susceptibility\/\">UNC Center for Environmental Health and Susceptibility<\/a>.<\/p>\n<h2>Impact and Broader Applicability<\/h2>\n<p>Based on the results of this pilot analysis there exists the potential for more widespread implications including, but not limited to, regulatory guidance of e-cigarette use, educational materials for e-cigarettes users on the potential risks for bladder cancer (especially for young adults), and even inform health care providers on how to better counsel patients.<\/p>\n<p>Regardless, the researchers hope that this pilot analysis will lay the foundation for additional funding through the <a href=\"https:\/\/www.cancer.gov\/\">National Cancer Institute<\/a> to further characterize the health implications of e-cigarettes use.<\/p>\n<h2>About the Primary Investigators<\/h2>\n<div class=\"row  oscitas-bootstrap-container\">\n<div class=\"col-lg-8 col-md-8 col-xs-12 col-sm-8 oscitas-bootstrap-container\"><a name=\"bjurlin\"><\/a><\/p>\n<h4><a href=\"https:\/\/www.med.unc.edu\/urology\/directory\/marc-bjurlin-do\/\">Marc Bjurlin, DO, MSc, FACOS<\/a><\/h4>\n<p>Dr. Bjurlin is a Physician and Researcher within the UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center. His clinical practice is focused on urologic oncology\u2014in particular, the treatment of bladder, prostate, testis, and kidney cancer. In addition to patient care, Dr. Bjurlin participates in research focused on employing advanced surgical procedures including the use of robotic surgery to maximize the quality of life for people with urologic malignancies.<\/div>\n<div class=\"col-lg-4 col-md-4 col-xs-12 col-sm-4 oscitas-bootstrap-container\">\n<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-4410 size-medium\" style=\"box-shadow: 0 4px 12px 0 rgba(0, 0, 0, 0.3); border: 2px solid #fff; margin-bottom: 5px;\" src=\"https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2018\/10\/Bjurlin-300x300.jpg\" alt=\"Marc Bjurlin, DO, MSc,\" width=\"300\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2018\/10\/Bjurlin-300x300.jpg 300w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2018\/10\/Bjurlin-150x150.jpg 150w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2018\/10\/Bjurlin-768x768.jpg 768w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2018\/10\/Bjurlin-600x600.jpg 600w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2018\/10\/Bjurlin-560x560.jpg 560w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2018\/10\/Bjurlin.jpg 1000w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/div>\n<\/div>\n<div class=\"row  oscitas-bootstrap-container\">\n<div class=\"col-lg-8 col-md-8 col-xs-12 col-sm-8 oscitas-bootstrap-container\"><a name=\"gordon\"><\/a><\/p>\n<h4><a href=\"https:\/\/med.nyu.edu\/faculty\/terry-gordon\">Terry Gordon, Ph.D.<\/a><\/h4>\n<p>Dr. Gordon&#8217;s research program at the NYU School of Medicine employs both human and animal models to study susceptibility factors\u2014including genetics, age, and gender\u2014underlying the adverse pulmonary and cardiac effects of environmental and occupational air pollutants.<\/div>\n<div class=\"col-lg-4 col-md-4 col-xs-12 col-sm-4 oscitas-bootstrap-container\">\n<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-6479 size-medium\" style=\"box-shadow: 0 4px 12px 0 rgba(0, 0, 0, 0.3); border: 2px solid #fff; margin-bottom: 5px;\" src=\"https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/terry_gordon-e1570470646677-300x300.jpg\" alt=\"Terry Gordon, Ph.D.\" width=\"300\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/terry_gordon-e1570470646677-300x300.jpg 300w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/terry_gordon-e1570470646677-150x150.jpg 150w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/terry_gordon-e1570470646677-768x768.jpg 768w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/terry_gordon-e1570470646677-1024x1024.jpg 1024w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/terry_gordon-e1570470646677-64x64.jpg 64w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/terry_gordon-e1570470646677-600x600.jpg 600w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/terry_gordon-e1570470646677.jpg 1680w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/div>\n<\/div>\n<div class=\"row  oscitas-bootstrap-container\">\n<div class=\"col-lg-8 col-md-8 col-xs-12 col-sm-8 oscitas-bootstrap-container\"><a name=\"jaspers\"><\/a><\/p>\n<h4><a href=\"https:\/\/sph.unc.edu\/adv_profile\/ilona-jaspers\/\">Ilona Jaspers, Ph.D.<\/a><\/h4>\n<p>Dr. Jaspers is a professor at the UNC Gillings School of Global Public Health<strong>\u00a0<\/strong>who specializes in the effects of ambient air pollutants on respiratory immune disfunction. Jaspers has established several human\u00a0<em>in vitro<\/em>\u00a0and clinical\u00a0<em>in vivo\u00a0<\/em>models to determine the adverse health effects induced by pollutant exposures.<\/div>\n<div class=\"col-lg-4 col-md-4 col-xs-12 col-sm-4 oscitas-bootstrap-container\">\n<img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-6480 size-medium\" style=\"box-shadow: 0 4px 12px 0 rgba(0, 0, 0, 0.3); border: 2px solid #fff; margin-bottom: 5px;\" src=\"https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/Ilona_Jaspers-e1570470692668-300x300.jpg\" alt=\"Ilona Jaspers, Ph.D.\" width=\"300\" height=\"300\" srcset=\"https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/Ilona_Jaspers-e1570470692668-300x300.jpg 300w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/Ilona_Jaspers-e1570470692668-150x150.jpg 150w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/Ilona_Jaspers-e1570470692668-768x768.jpg 768w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/Ilona_Jaspers-e1570470692668-64x64.jpg 64w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/Ilona_Jaspers-e1570470692668-600x600.jpg 600w, https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/Ilona_Jaspers-e1570470692668.jpg 780w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/div>\n<\/div>\n<hr \/>\n<h4>References<\/h4>\n<ol>\n<li>Rubinstein ML, Delucchi K, Benowitz NL, Ramo DE. Adolescent Exposure to Toxic Volatile Organic Chemicals From E-Cigarettes. Pediatrics. 2018;141(4).<\/li>\n<li>Goniewicz ML, Smith DM, Edwards KC, et al. Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes. JAMA Netw Open. 2018;1(8):e185937.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>A recently approved funding proposal through NC TraCS and NYU to characterize carcinogenic biomarkers found in the urine of young adult e-cigarette users will soon be underway. The proposal put together by UNC Urologist Dr. Marc Bjurlin, Dr. Ilona Jaspers, and Dr. Terry Gordon hopes to not only better understand the types of bladder cancer-causing biomarkers in e-cigarette user urine, but also strengthen the foundation for future e-cigarette research and regulations.<\/p>\n","protected":false},"author":79967,"featured_media":4410,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"categories":[1],"tags":[63],"class_list":["post-6475","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-bjurlin","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Funding Approved For Pilot Analysis Of Bladder Carcinogens In The Urine Of Young Adult E-Cigarettes Users<\/title>\n<meta name=\"description\" content=\"A recently approved funding proposal through NC TraCS and NYU to characterize carcinogenic biomarkers found in the urine of young adult e-cigarette ...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/urology\/funding-approved-for-pilot-analysis-of-bladder-carcinogens-in-the-urine-of-young-adult-e-cigarettes-users\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Funding Approved For Pilot Analysis Of Bladder Carcinogens In The Urine Of Young Adult E-Cigarettes Users\" \/>\n<meta property=\"og:description\" content=\"A recently approved funding proposal through NC TraCS and NYU to characterize carcinogenic biomarkers found in the urine of young adult e-cigarette users will soon be underway. The proposal put together by UNC Urologist Dr. Marc Bjurlin, Dr. Ilona Jaspers, and Dr. Terry Gordon hopes to not only better understand the types of bladder cancer-causing biomarkers in e-cigarette user urine, but also strengthen the foundation for future e-cigarette research and regulations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/urology\/funding-approved-for-pilot-analysis-of-bladder-carcinogens-in-the-urine-of-young-adult-e-cigarettes-users\/\" \/>\n<meta property=\"og:site_name\" content=\"Department of Urology\" \/>\n<meta property=\"article:published_time\" content=\"2019-10-17T09:00:49+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2020-04-08T20:01:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/NCTraCS_NYUL_logo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"500\" \/>\n\t<meta property=\"og:image:height\" content=\"250\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Bradley Olson\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"Funding Approved For Pilot Analysis Of Bladder Carcinogens In The Urine Of Young Adult E-Cigarettes Users\" \/>\n<meta name=\"twitter:description\" content=\"A recently approved funding proposal through NC TraCS and NYU to characterize carcinogenic biomarkers found in the urine of young adult e-cigarette users will soon be underway. The proposal put together by UNC Urologist Dr. Marc Bjurlin, Dr. Ilona Jaspers, and Dr. Terry Gordon hopes to not only better understand the types of bladder cancer-causing biomarkers in e-cigarette user urine, but also strengthen the foundation for future e-cigarette research and regulations.\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/www.med.unc.edu\/urology\/wp-content\/uploads\/sites\/637\/2019\/10\/NCTraCS_NYUL_logo.jpg\" \/>\n<meta name=\"twitter:creator\" content=\"@UNCurology\" \/>\n<meta name=\"twitter:site\" content=\"@UNCurology\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Bradley Olson\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" 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