{"id":2246,"date":"2018-10-11T16:13:21","date_gmt":"2018-10-11T20:13:21","guid":{"rendered":"https:\/\/www.med.unc.edu\/vazirilab\/?page_id=2246"},"modified":"2018-12-04T16:19:34","modified_gmt":"2018-12-04T21:19:34","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/vazirilab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<div class=\"soliloquy-outer-container soliloquy-carousel\" data-soliloquy-loaded=\"0\"><div aria-live=\"polite\" id=\"soliloquy-container-2405\" class=\"soliloquy-container soliloquy-transition-horizontal soliloquy-slide-horizontal soliloquy-controls-active  soliloquy-theme-base no-js\" style=\"max-width:768px;margin:0 auto 30px;\"><ul id=\"soliloquy-2405\" class=\"soliloquy-slider soliloquy-slides soliloquy-wrap soliloquy-clear\"><li aria-hidden=\"true\" class=\"soliloquy-item soliloquy-item-1 soliloquy-id-2406 soliloquy-image-slide\" draggable=\"false\" style=\"list-style:none;\"><a href=\"http:\/\/www.jbc.org\/content\/281\/41\/30631.long\" class=\"soliloquy-link\" title=\"The DNA replication factor CDC45 induces chromatin decondensation\" target=\"_blank\" rel=\"soliloquybox2405\" data-soliloquy-lightbox-caption=\"Vaziri Lab: JBC 2006\" data-thumbnail=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Eight-1-75x50_c.jpg\"><img decoding=\"async\" loading=\"lazy\" id=\"soliloquy-image-2406\" class=\"soliloquy-image soliloquy-image-1\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Eight-1-768x286.jpg\" width=\"1200\" height=\"600\" alt=\"The DNA replication factor CDC45 induces chromatin decondensation\" \/><\/a><div class=\"soliloquy-caption soliloquy-caption-bottom\"><div class=\"soliloquy-caption-inside\">Vaziri Lab: JBC 2006<\/div><\/div><\/li><li aria-hidden=\"true\" class=\"soliloquy-item soliloquy-item-2 soliloquy-id-2407 soliloquy-image-slide\" draggable=\"false\" style=\"list-style:none;\"><a href=\"https:\/\/academic.oup.com\/nar\/article\/41\/4\/2296\/2414731\" class=\"soliloquy-link\" title=\"DNA Double-Stranded Breaks accumulate when TLS and NHEJ are compromised\" target=\"_blank\" rel=\"soliloquybox2405\" data-soliloquy-lightbox-caption=\"Variri Lab: NAR 2013\" data-thumbnail=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Five-1-75x50_c.jpg\"><img decoding=\"async\" loading=\"lazy\" id=\"soliloquy-image-2407\" class=\"soliloquy-image soliloquy-image-2\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Five-1-768x279.jpg\" width=\"1200\" height=\"600\" alt=\"DNA Double-Stranded Breaks accumulate when TLS and NHEJ are compromised\" \/><\/a><div class=\"soliloquy-caption soliloquy-caption-bottom\"><div class=\"soliloquy-caption-inside\">Variri Lab: NAR 2013<\/div><\/div><\/li><li aria-hidden=\"true\" class=\"soliloquy-item soliloquy-item-3 soliloquy-id-2408 soliloquy-image-slide\" draggable=\"false\" style=\"list-style:none;\"><a href=\"https:\/\/doi.org\/10.1016\/S1097-2765(03)00099-6\" class=\"soliloquy-link\" title=\"Re-replicating regions of chromosomes (red) in Cdt1 over-expressing cells\" target=\"_blank\" rel=\"soliloquybox2405\" data-soliloquy-lightbox-caption=\"Vaziri Lab: Mol Cell 2003\" data-thumbnail=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Four-1-75x50_c.jpg\"><img decoding=\"async\" loading=\"lazy\" id=\"soliloquy-image-2408\" class=\"soliloquy-image soliloquy-image-3\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Four-1.jpg\" width=\"1200\" height=\"600\" alt=\"Re-replicating regions of chromosomes (red) in Cdt1 over-expressing cells\" \/><\/a><div class=\"soliloquy-caption soliloquy-caption-bottom\"><div class=\"soliloquy-caption-inside\">Vaziri Lab: Mol Cell 2003<\/div><\/div><\/li><li aria-hidden=\"true\" class=\"soliloquy-item soliloquy-item-4 soliloquy-id-2409 soliloquy-image-slide\" draggable=\"false\" style=\"list-style:none;\"><a href=\"http:\/\/jcb.rupress.org\/content\/216\/10\/3097.long\" class=\"soliloquy-link\" title=\"Flow cytometry data showing aberrant accumulation of single-stranded DNA in Polk-\/- cells\" target=\"_blank\" rel=\"soliloquybox2405\" data-soliloquy-lightbox-caption=\"Vaziri Lab: JCB 2017\" data-thumbnail=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-One-1-75x50_c.jpg\"><img decoding=\"async\" loading=\"lazy\" id=\"soliloquy-image-2409\" class=\"soliloquy-image soliloquy-image-4\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-One-1-768x338.jpg\" width=\"1200\" height=\"600\" alt=\"Flow cytometry data showing aberrant accumulation of single-stranded DNA in Polk-\/- cells\" \/><\/a><div class=\"soliloquy-caption soliloquy-caption-bottom\"><div class=\"soliloquy-caption-inside\">Vaziri Lab: JCB 2017<\/div><\/div><\/li><li aria-hidden=\"true\" class=\"soliloquy-item soliloquy-item-5 soliloquy-id-2410 soliloquy-image-slide\" draggable=\"false\" style=\"list-style:none;\"><a href=\"https:\/\/academic.oup.com\/nar\/article\/44\/9\/4174\/2462264\" class=\"soliloquy-link\" title=\"Defective localization of Fancd2 in Rad18-\/- spermatocytes\" target=\"_blank\" rel=\"soliloquybox2405\" data-soliloquy-lightbox-caption=\"Vaziri Lab: NAR 2016\" data-thumbnail=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Seven-1-75x50_c.jpg\"><img decoding=\"async\" loading=\"lazy\" id=\"soliloquy-image-2410\" class=\"soliloquy-image soliloquy-image-5\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Seven-1-768x340.jpg\" width=\"1200\" height=\"600\" alt=\"Defective localization of Fancd2 in Rad18-\/- spermatocytes\" \/><\/a><div class=\"soliloquy-caption soliloquy-caption-bottom\"><div class=\"soliloquy-caption-inside\">Vaziri Lab: NAR 2016<\/div><\/div><\/li><li aria-hidden=\"true\" class=\"soliloquy-item soliloquy-item-6 soliloquy-id-2411 soliloquy-image-slide\" draggable=\"false\" style=\"list-style:none;\"><a href=\"https:\/\/academic.oup.com\/nar\/article\/41\/4\/2296\/2414731\" class=\"soliloquy-link\" title=\"Subcellular distribution of DNA Polymerase eta (Polh) in hydrogen peroxide-treated cells\" target=\"_blank\" rel=\"soliloquybox2405\" data-soliloquy-lightbox-caption=\"Vaziri Lab: NAR 2013\" data-thumbnail=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Six-1-75x50_c.jpg\"><img decoding=\"async\" loading=\"lazy\" id=\"soliloquy-image-2411\" class=\"soliloquy-image soliloquy-image-6\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Six-1-768x272.jpg\" width=\"1200\" height=\"600\" alt=\"Subcellular distribution of DNA Polymerase eta (Polh) in hydrogen peroxide-treated cells\" \/><\/a><div class=\"soliloquy-caption soliloquy-caption-bottom\"><div class=\"soliloquy-caption-inside\">Vaziri Lab: NAR 2013<\/div><\/div><\/li><li aria-hidden=\"true\" class=\"soliloquy-item soliloquy-item-7 soliloquy-id-2412 soliloquy-image-slide\" draggable=\"false\" style=\"list-style:none;\"><a href=\"https:\/\/www.nature.com\/articles\/ncomms12105\" class=\"soliloquy-link\" title=\"Subcellular distribution of DNA Repair protein RAD18 and MAGEA4 in cancer cells\" target=\"_blank\" rel=\"soliloquybox2405\" data-soliloquy-lightbox-caption=\"Vaziri Lab: Nature Communications 2016\" data-thumbnail=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Three-1-75x50_c.jpg\"><img decoding=\"async\" loading=\"lazy\" id=\"soliloquy-image-2412\" class=\"soliloquy-image soliloquy-image-7\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Three-1-768x232.jpg\" width=\"1200\" height=\"600\" alt=\"Subcellular distribution of DNA Repair protein RAD18 and MAGEA4 in cancer cells\" \/><\/a><div class=\"soliloquy-caption soliloquy-caption-bottom\"><div class=\"soliloquy-caption-inside\">Vaziri Lab: Nature Communications 2016<\/div><\/div><\/li><li aria-hidden=\"true\" class=\"soliloquy-item soliloquy-item-8 soliloquy-id-2413 soliloquy-image-slide\" draggable=\"false\" style=\"list-style:none;\"><a href=\"https:\/\/www.nature.com\/articles\/s41598-018-33601-w\" class=\"soliloquy-link\" title=\"Expression of the HORMAD1 (a Cancer Testes Antigen) and Homologous Recombination genes is associated with copy number variation (CNV) in cancer\" target=\"_blank\" rel=\"soliloquybox2405\" data-soliloquy-lightbox-caption=\"Vaziri Lab: Scientific Reports 2018\" data-thumbnail=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Two-1-75x50_c.jpg\"><img decoding=\"async\" loading=\"lazy\" id=\"soliloquy-image-2413\" class=\"soliloquy-image soliloquy-image-8\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Two-1-768x219.jpg\" width=\"1200\" height=\"600\" alt=\"Expression of the HORMAD1 (a Cancer Testes Antigen) and Homologous Recombination genes is associated with copy number variation (CNV) in cancer\" \/><\/a><div class=\"soliloquy-caption soliloquy-caption-bottom\"><div class=\"soliloquy-caption-inside\">Vaziri Lab: Scientific Reports 2018<\/div><\/div><\/li><\/ul><\/div><noscript><div class=\"soliloquy-no-js\" style=\"display:none;visibility:hidden;height:0;line-height:0;opacity:0;\"><img decoding=\"async\" class=\"soliloquy-image soliloquy-no-js-image skip-lazy\" loading=\"lazy\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Eight-1-768x286.jpg\" alt=\"The DNA replication factor CDC45 induces chromatin decondensation\" \/><img decoding=\"async\" class=\"soliloquy-image soliloquy-no-js-image skip-lazy\" loading=\"lazy\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Five-1-768x279.jpg\" alt=\"DNA Double-Stranded Breaks accumulate when TLS and NHEJ are compromised\" \/><img decoding=\"async\" class=\"soliloquy-image soliloquy-no-js-image skip-lazy\" loading=\"lazy\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Four-1.jpg\" alt=\"Re-replicating regions of chromosomes (red) in Cdt1 over-expressing cells\" \/><img decoding=\"async\" class=\"soliloquy-image soliloquy-no-js-image skip-lazy\" loading=\"lazy\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-One-1-768x338.jpg\" alt=\"Flow cytometry data showing aberrant accumulation of single-stranded DNA in Polk-\/- cells\" \/><img decoding=\"async\" class=\"soliloquy-image soliloquy-no-js-image skip-lazy\" loading=\"lazy\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Seven-1-768x340.jpg\" alt=\"Defective localization of Fancd2 in Rad18-\/- spermatocytes\" \/><img decoding=\"async\" class=\"soliloquy-image soliloquy-no-js-image skip-lazy\" loading=\"lazy\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Six-1-768x272.jpg\" alt=\"Subcellular distribution of DNA Polymerase eta (Polh) in hydrogen peroxide-treated cells\" \/><img decoding=\"async\" class=\"soliloquy-image soliloquy-no-js-image skip-lazy\" loading=\"lazy\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Three-1-768x232.jpg\" alt=\"Subcellular distribution of DNA Repair protein RAD18 and MAGEA4 in cancer cells\" \/><img decoding=\"async\" class=\"soliloquy-image soliloquy-no-js-image skip-lazy\" loading=\"lazy\" src=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/12\/Publications_Vaziri-Two-1-768x219.jpg\" alt=\"Expression of the HORMAD1 (a Cancer Testes Antigen) and Homologous Recombination genes is associated with copy number variation (CNV) in cancer\" \/><\/div><\/noscript><\/div>\n<h3><strong>Recent Publications:<\/strong><\/h3>\n<p>Tanoue Y, Toyoda T, Sun J, Mustofa MK, Tateishi C, Endo S, Motoyama N, Araki K, Wu D, Okuno Y, Tsukamoto T, Takeya M, Ihn H, Vaziri C, Tateishi S. Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure.\u00a0 J Invest Dermatol. 2018 May 31. pii: S0022-202X(18)32036-0. doi: 10.1016\/j.jid.2018.05.015. [Epub ahead of print] <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Differential+Roles+of+Rad18+and+Chk2+in+Genome+Maintenance+and+Skin+Carcinogenesis+Following+UV+Exposure.\">PMID: 29859927<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>Yang Y, Gao Y, Zlatanou A, Tateishi S, Yurchenko V, Rogozin IB, Vaziri C.\u00a0 Diverse roles of RAD18 and Y-family DNA polymerases in tumorigenesis\u00a0 Cell Cycle. 2018 May 8:1-11. doi: 10.1080\/15384101.2018.1456296. [Epub ahead of print] <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Diverse+roles+of+RAD18+and+Y-family+DNA+polymerases+in+tumorigenesis%C2%A0+Cell+Cycle\">PMID: 29683380<\/a><\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/11\/Diverse-roles-of-RAD18-and-Y-family-DNA-polymerases-in-tumorigenesis.pdf\">Diverse roles of RAD18 and Y family DNA polymerases in tumorigenesis<\/a><\/p>\n<p><i>In this invited review we discuss the significance of our recent findings that TLS is aberrantly activated in cancer and confers tolerance of oncogenic stress<\/i><\/p>\n<p>Yang Y, Gao Y, Mutter-Rottmayer L, Zlatanou A, Durando M, Ding W, Wyatt D, Ramsden D, Tanoue Y, Tateishi S, Vaziri C.\u00a0 DNA repair factor RAD18 and DNA polymerase Pol\u03ba confer tolerance of oncogenic DNA replication stress.\u00a0 J Cell Biol. 2017 Oct 2;216(10):3097-3115. doi: 10.1083\/jcb.201702006. Epub 2017 Aug 23. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=DNA+repair+factor+RAD18+and+DNA+polymerase+Pol%CE%BA+confer+tolerance+of+oncogenic+DNA+replication+stress\">PMID: 28835467<\/a><\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/11\/DNA-repair-factor-RAD18-and-DNA-polymerase-Pol\u03ba-confer-tolerance-of-oncogenic-DNA-replication-stress.pdf\">DNA repair factor RAD18 and DNA polymerase Pol\u03ba confer tolerance of oncogenic DNA replication stress<\/a><\/p>\n<p><i>In this study we showed that RAD18-mediated TLS allows cells to tolerate oncogene-induced DNA damage.\u00a0 In the absence of TLS, oncogene-induced DNA damage leads mitotic catastrophe.\u00a0 These results explain our previous finding that many cancer cells pathologically activate TLS (Gao et al., Nature Communications 2016).<\/i><\/p>\n<p><i>This article was selected by JCB for inclusion in a special collection of articles that advanced the fields of Nuclear organization and function (http:\/\/jcb.rupress.org\/cc\/nuclear-organization-and-function). From the journal web site: \u201cIn this special collection, JCB Editorial Board Member Ana Pombo and Senior Scientific Editor Melina <\/i><i>Casadio<\/i><i> selected some of JCB&#8217;s most highly read recent content exploring chromatin structure and how it relates to gene expression and genome functions such as DNA replication and repair. This collection sheds light on genome organization and chromosome conformation, chromatin partners and dynamics during development and disease, and how emerging imaging technologies advance the field.\u201d<\/i><\/p>\n<p>Li J, Liu J, Liang Z, He F, Yang L, Li P, Jiang Y, Wang B, Zhou C, Wang Y, Ren Y, Yang J, Zhang J, Luo Z, Vaziri C, Liu P. (2017) Simvastatin and Atorvastatin inhibit DNA replication licensing factor MCM7 and effectively suppress RB-deficient tumors growth. Cell Death Dis. Mar 16;8(3):e2673. doi: 10.1038\/cddis.2017.46. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Simvastatin+and+Atorvastatin+inhibit+DNA+replication+licensing+factor+MCM7+and+effectively+suppress+RB-deficient+tumors+growth\">PMID: 28300827<\/a><\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/11\/Simvastatin-and-Atorvastatin-inhibit-DNA-replication-licensing-factor-MCM7-and-effectively-suppress-RB-deficient-tumors-growth.pdf\">Simvastatin and Atorvastatin inhibit DNA replication licensing factor MCM7 and effectively suppress RB-deficient tumors growth<\/a><\/p>\n<p>Gao Y, Mutter-Rottmayer E, Zlatanou A, Vaziri C, Yang Y. (2017) Mechanisms of Post-Replication DNA Repair. Genes (Basel) 8;8(2). pii: E64. doi: 10.3390\/genes8020064. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28208741\">PMID: 28208741\u00a0<\/a><\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/11\/Mechanism-of-Post-Replication-DNA-Repair.pdf\">Mechanism of Post Replication DNA Repair<\/a><\/p>\n<p>Liang Z, Li W, Liu J, Li J, He F, Jiang Y, Yang L, Li P, Wang B, Wang Y, Ren Y, Yang J, Luo Z, Vaziri C, Liu P. (2017) Simvastatin suppresses the DNA replication licensing factor MCM7 and inhibits the growth of tamoxifen-resistant breast cancer cells. Sci Rep. 7:41776. doi: 10.1038\/srep41776. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Simvastatin+suppresses+the+DNA+replication+licensing+factor+MCM7+and+inhibits+the+growth+of+tamoxifen-resistant+breast+cancer+cells\">PMID: 28150753<\/a><\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/11\/Simvastatin-suppresses-the-DNA-replication-licensing-factor-MCM7-and-inhibits-the-growth-of-tamoxifen-resistant-breast-cancer-cells.pdf\">Simvastatin suppresses the DNA replication licensing factor MCM7 and inhibits the growth of tamoxifen-resistant breast cancer cells<\/a><\/p>\n<p>Mutter-Rottmayer E, Gao Y, Vaziri C. (2016) Cancer cells activate damage-tolerant and error-prone DNA synthesis. Mol Cell Oncol. 3(6):e1225547. doi: 10.1080\/23723556.2016.1225547. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Cancer+cells+activate+damage-tolerant+and+error-prone+DNA+synthesis\">PMID: 28090576<\/a><\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/11\/Cancer-cells-activate-damage-tolerant-and-error-prone-DNA-synthesis.pdf\">Cancer cells activate damage tolerant and error prone DNA synthesis<\/a><\/p>\n<p>Gao Y, Tateishi S., Vaziri C. (2016) Pathological Trans-Lesion Synthesis in Cancer.\u00a0 Cell Cycle 2016 15(22):3005-3006. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27462757\">PMID: 27462757<\/a><\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/11\/Pathological-trans-lesion-synthesis-in-cancer.pdf\">Pathological trans lesion synthesis in cancer<\/a><\/p>\n<p>Gao Y, Mutter-Rottmayer E, Greenwalt A M, Goldfarb D, Yan F, Yang Y, Martinez RC, Pearce KH, Tateishi S, Major MB, Vaziri C. (2016) A Neomorphic cancer cell-Specific Role of MAGE-A4 in Trans-Lesion Synthesis. Nature Commun. 2016 Jul 5;7:12105. doi: 10.1038\/ncomms12105\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=A+Neomorphic+cancer+cell-Specific+Role+of+MAGE-A4+in+Trans-Lesion+Synthesis\">PMID: 27377895<\/a><\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/11\/A-neomorphic-cancer-cell-specific-role-of-MAGE-A4-in-trans-lesion-synthesis.pdf\">A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis<\/a><\/p>\n<p><i>This study identifies a novel mechanism by which cancer cells deploy a <\/i><i>mis<\/i><i>-expressed germ cell protein (MAGE-A4) to activate TLS and become DNA damage-tolerant.\u00a0<\/i><\/p>\n<p>Yang Y, Poe JC, Yang L, Fedoriw A, Desai S, Magnuson T, Li Z, Fedoriw Y, Araki K, Gao Y, Tateishi S, Sarantopoulos S, Vaziri C. (2015) Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo. Nucleic Acids Res. 2016 44(9):4174-88 <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Rad18+confers+hematopoietic+progenitor+cell+DNA+damage+tolerance+independently+of+the+Fanconi+Anemia+pathway+in+vivo\">PMID: 26883629<\/a><\/p>\n<p><a href=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/11\/Rad18-confers-hematopoietic-progenitor-cell-DNA-damage-tolerance-independently-of-the-Fanconi-Anemia-pathway-in-vivo.pdf\">Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo<\/a><\/p>\n<h3><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Vaziri+C\"><strong>Click Here for Cyrus Vaziri Publications via PubMed<\/strong><\/a><\/h3>\n","protected":false},"excerpt":{"rendered":"<p>Recent Publications: Tanoue Y, Toyoda T, Sun J, Mustofa MK, Tateishi C, Endo S, Motoyama N, Araki K, Wu D, Okuno Y, Tsukamoto T, Takeya M, Ihn H, Vaziri C, Tateishi S. Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure.\u00a0 J Invest Dermatol. 2018 May 31. pii: S0022-202X(18)32036-0. &hellip; <a href=\"https:\/\/www.med.unc.edu\/vazirilab\/publications\/\" aria-label=\"Read more about Publications\">Read more<\/a><\/p>\n","protected":false},"author":28418,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2246","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Publications - Vaziri Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/vazirilab\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications - Vaziri Lab\" \/>\n<meta property=\"og:description\" content=\"Recent Publications: Tanoue Y, Toyoda T, Sun J, Mustofa MK, Tateishi C, Endo S, Motoyama N, Araki K, Wu D, Okuno Y, Tsukamoto T, Takeya M, Ihn H, Vaziri C, Tateishi S. Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure.\u00a0 J Invest Dermatol. 2018 May 31. pii: S0022-202X(18)32036-0. &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/vazirilab\/publications\/\" \/>\n<meta property=\"og:site_name\" content=\"Vaziri Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2018-12-04T21:19:34+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/vazirilab\/publications\/\",\"url\":\"https:\/\/www.med.unc.edu\/vazirilab\/publications\/\",\"name\":\"Publications - Vaziri Lab\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/vazirilab\/#website\"},\"datePublished\":\"2018-10-11T20:13:21+00:00\",\"dateModified\":\"2018-12-04T21:19:34+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/vazirilab\/publications\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/vazirilab\/publications\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/vazirilab\/publications\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/vazirilab\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/vazirilab\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/vazirilab\/\",\"name\":\"UNC Cyrus Vaziri Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/vazirilab\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Publications - Vaziri Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/vazirilab\/publications\/","og_locale":"en_US","og_type":"article","og_title":"Publications - Vaziri Lab","og_description":"Recent Publications: Tanoue Y, Toyoda T, Sun J, Mustofa MK, Tateishi C, Endo S, Motoyama N, Araki K, Wu D, Okuno Y, Tsukamoto T, Takeya M, Ihn H, Vaziri C, Tateishi S. Differential Roles of Rad18 and Chk2 in Genome Maintenance and Skin Carcinogenesis Following UV Exposure.\u00a0 J Invest Dermatol. 2018 May 31. pii: S0022-202X(18)32036-0. &hellip; Read more","og_url":"https:\/\/www.med.unc.edu\/vazirilab\/publications\/","og_site_name":"Vaziri Lab","article_modified_time":"2018-12-04T21:19:34+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.med.unc.edu\/vazirilab\/publications\/","url":"https:\/\/www.med.unc.edu\/vazirilab\/publications\/","name":"Publications - Vaziri Lab","isPartOf":{"@id":"https:\/\/www.med.unc.edu\/vazirilab\/#website"},"datePublished":"2018-10-11T20:13:21+00:00","dateModified":"2018-12-04T21:19:34+00:00","breadcrumb":{"@id":"https:\/\/www.med.unc.edu\/vazirilab\/publications\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.med.unc.edu\/vazirilab\/publications\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.med.unc.edu\/vazirilab\/publications\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.med.unc.edu\/vazirilab\/"},{"@type":"ListItem","position":2,"name":"Publications"}]},{"@type":"WebSite","@id":"https:\/\/www.med.unc.edu\/vazirilab\/#website","url":"https:\/\/www.med.unc.edu\/vazirilab\/","name":"UNC Cyrus Vaziri Lab","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.med.unc.edu\/vazirilab\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/vazirilab\/wp-json\/wp\/v2\/pages\/2246","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/vazirilab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/vazirilab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/vazirilab\/wp-json\/wp\/v2\/users\/28418"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/vazirilab\/wp-json\/wp\/v2\/comments?post=2246"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/vazirilab\/wp-json\/wp\/v2\/pages\/2246\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/vazirilab\/wp-json\/wp\/v2\/media?parent=2246"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}