{"id":2315,"date":"2018-10-24T15:39:11","date_gmt":"2018-10-24T19:39:11","guid":{"rendered":"https:\/\/www.med.unc.edu\/vazirilab\/?page_id=2315"},"modified":"2018-10-24T15:40:16","modified_gmt":"2018-10-24T19:40:16","slug":"about-us","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/vazirilab\/about-us\/","title":{"rendered":"About Us"},"content":{"rendered":"

What We Study:<\/i><\/b><\/u><\/p>\n

How cancer genomes arise and how cancer cells tolerate DNA damage.<\/p>\n

Why We Study These Problems: <\/i><\/b><\/u><\/p>\n

Mutagenesis and DNA damage tolerance drive carcinogenesis and enable cancer cells to adapt, evolve and resist therapy.\u00a0 Understanding mechanisms of mutagenesis and DNA damage tolerance will help explain how cancer arises and identify molecular vulnerabilities that can be exploited to prevent and treat cancer.<\/p>\n

\"\"<\/p>\n

Our Approach: <\/i><\/b><\/u><\/p>\n

Trans-Lesion Synthesis (TLS) is a specialized mode of DNA replication that is both error-prone and DNA damage-tolerant.<\/p>\n

We have found that cancer cells specifically activate TLS.\u00a0 Therefore, TLS provides potential ways for cancer cells to mutate their genomes and resist intrinsic and therapeutic stress.\u00a0 We are using diverse approaches to elucidate regulatory mechanisms and roles of TLS in normal cells and cancer cells.<\/p>\n

\"\"<\/p>\n

Key words:\u00a0 <\/i><\/b><\/u><\/p>\n

Cell Cycle, DNA Replication, DNA Repair, Mutagenesis, Cancer, Chemotherapy, Biochemistry, Molecular Biology, Genetics & Genomics<\/p>\n","protected":false},"excerpt":{"rendered":"

What We Study: How cancer genomes arise and how cancer cells tolerate DNA damage. Why We Study These Problems: Mutagenesis and DNA damage tolerance drive carcinogenesis and enable cancer cells to adapt, evolve and resist therapy.\u00a0 Understanding mechanisms of mutagenesis and DNA damage tolerance will help explain how cancer arises and identify molecular vulnerabilities that … Read more<\/a><\/p>\n","protected":false},"author":28418,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2315","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"\nAbout Us - Vaziri Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/vazirilab\/about-us\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"About Us - Vaziri Lab\" \/>\n<meta property=\"og:description\" content=\"What We Study: How cancer genomes arise and how cancer cells tolerate DNA damage. Why We Study These Problems: Mutagenesis and DNA damage tolerance drive carcinogenesis and enable cancer cells to adapt, evolve and resist therapy.\u00a0 Understanding mechanisms of mutagenesis and DNA damage tolerance will help explain how cancer arises and identify molecular vulnerabilities that … Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/vazirilab\/about-us\/\" \/>\n<meta property=\"og:site_name\" content=\"Vaziri Lab\" \/>\n<meta property=\"article:modified_time\" content=\"2018-10-24T19:40:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/10\/Vaziri-Why-We-Study-Graphic-300x84.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/vazirilab\/about-us\/\",\"url\":\"https:\/\/www.med.unc.edu\/vazirilab\/about-us\/\",\"name\":\"About Us - Vaziri Lab\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/vazirilab\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/www.med.unc.edu\/vazirilab\/about-us\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/www.med.unc.edu\/vazirilab\/about-us\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/10\/Vaziri-Why-We-Study-Graphic-300x84.jpg\",\"datePublished\":\"2018-10-24T19:39:11+00:00\",\"dateModified\":\"2018-10-24T19:40:16+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/vazirilab\/about-us\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/vazirilab\/about-us\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.med.unc.edu\/vazirilab\/about-us\/#primaryimage\",\"url\":\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/10\/Vaziri-Why-We-Study-Graphic.jpg\",\"contentUrl\":\"https:\/\/www.med.unc.edu\/vazirilab\/wp-content\/uploads\/sites\/648\/2018\/10\/Vaziri-Why-We-Study-Graphic.jpg\",\"width\":796,\"height\":222},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/vazirilab\/about-us\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/vazirilab\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"About Us\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/vazirilab\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/vazirilab\/\",\"name\":\"UNC Cyrus Vaziri Lab\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/vazirilab\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"About Us - Vaziri Lab","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/vazirilab\/about-us\/","og_locale":"en_US","og_type":"article","og_title":"About Us - Vaziri Lab","og_description":"What We Study: How cancer genomes arise and how cancer cells tolerate DNA damage. 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