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The Women’s Interagency HIV Study (WIHS) is a multi-center, longitudinal study designed to comprehensively characterize the long-term, natural and treated history of HIV infection . The core portion of the study consists of bi-annual visits which include a structured interview, comprehensive physical & gynecologic exam and specimen collection.

The WIHS was established in 1993 as a multi-center prospective cohort study of women who are either HIV-infected or at risk for HIV acquisition. WIHS plays an important role in effort to understand the current epidemiology of HIV infection, disease progression, treatment use and outcomes, and related co-morbidities among U.S. residents with HIV. Understanding differences in HIV disease and treatment outcomes between women compared to men, and in different racial and ethnic groups, is a critical public health goal.

To date, WIHS has conducted research on: novel statistics for analyzing observational cohort data; impact of viral resistance; the effect of co-infections such as hepatitis and human papillomavirus (HPV); therapy use and treatment effects in women with HIV; metabolic abnormalities and toxicities; the impact of hormonal factors on HIV disease including the transition into menopause; the effects of aging on HIV disease; behavioral research including substance use; the assessment of neurocognitive functioning, mental health and physical impairment among WIHS participants.

WIHS data and specimens also provide the platform for other HIV-related NIH-funded grants. As of June 2011, almost 500 publications have resulted from WIHS-directed and/or collaborative investigations.


This website is set up to provide general information about WIHS and to help researchers who are interested in developing grant applications, proposing new research studies or conducting analyses of existing data.

 Use the figure below to determine the resources that best fit your needs. "