The Women’s Interagency HIV Study (WIHS) is a multicenter longitudinal study funded by the National Institutes of Health (National Institute of Allergy and Infectious Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Drug Abuse, National Cancer Institute, and National Institute of Mental Health) to investigate the progression of HIV disease in women. As of December 2012, over 2,297 women were reported in active follow-up (completed the last visit).
Until 2012 WIHS was conducted at six clinical sites, including a New York City Consortium; the State University of New York at Brooklyn; a Washington, D.C., Consortium; a Los Angeles, Southern California Consortium; a San Francisco/Bay Area Consortium, and a Chicago Consortium. Since 1998, the WIHS Data Management and Analysis Center (WDMAC) has been located at the Johns Hopkins University Bloomberg School of Public Health, in Baltimore, Maryland.
Beginning in January 2013, with WIHS V, the Los Angeles, Southern California Consortium was closed and four new sites in the Southern U.S. were added, including sites in Atlanta, Georgia; Chapel Hill, North Carolina; Miami, Florida; and Birmingham, Alabama/Jackson, Mississippi.
All study participants undergo an initial screening to determine study eligibility. If the study participant is willing to take part in the study and gives informed consent, she will participate in an in-depth interview, physical exam, and specimen collection.
The data collected at each visit will include the following: medical and health history, obstetric/gynecological and contraceptive history, health care utilization, sexual behavior, usage of drugs and alcohol, psychosocial factors, sociodemographics, laboratory parameters and a physical and gynecological examination.
Until the most recent expansions, which added four new Southern sites, WIHS was a closed cohort of women from three prior enrollment waves: