{"id":2221,"date":"2018-04-10T13:44:53","date_gmt":"2018-04-10T17:44:53","guid":{"rendered":"https:\/\/med.sites.unc.edu\/wolberglab\/files\/2018\/04\/fibrinogen-synthesis-and-expression.jpeg"},"modified":"2018-04-10T13:46:38","modified_gmt":"2018-04-10T17:46:38","slug":"fibrinogen-synthesis-and-expression","status":"inherit","type":"attachment","link":"https:\/\/www.med.unc.edu\/wolberglab\/scientific-images-2\/fibrinogen-synthesis-and-expression\/","title":{"rendered":"Fibrinogen synthesis and expression"},"author":9746,"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"class_list":["post-2221","attachment","type-attachment","status-inherit","hentry","odd"],"acf":[],"description":{"rendered":"<p class=\"attachment\"><a class=\"thumbnail img-thumbnail\" href='https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression.jpeg'><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"239\" src=\"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression-300x239.jpeg\" class=\"attachment-medium size-medium\" alt=\"\" srcset=\"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression-300x239.jpeg 300w, https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression-150x120.jpeg 150w, https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression-768x613.jpeg 768w, https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression-1024x817.jpeg 1024w, https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression-642x512.jpeg 642w, https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression.jpeg 1280w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>Fibrinogen synthesis and expression. Fibrinogen synthesis is regulated by both transcriptional and translational mechanisms. After individual fibrinogen chains are translated, fibrinogen assembly occurs stepwise. Single chains assemble first into A\u03b1-\u03b3 and B\u03b2-\u03b3 precursors, then into A\u03b1\/B\u03b2\/\u03b3 half-molecules, and finally into hexameric complexes (A\u03b1\/B\u03b2\/\u03b3)2. Once fibrinogen is released into blood, it circulates until thrombin cleaves fibrinopeptides from the A\u03b1 and B\u03b2 chains (FpA and FpB, respectively) to form fibrin monomers. These monomers then polymerize in a half-staggered arrangement to form fibrin protofibrils and ultimately the fibrin network at a site of tissue injury.<\/p>\n"},"caption":{"rendered":"<p>Fibrinogen synthesis and expression. Fibrinogen synthesis is regulated by both transcriptional and translational mechanisms. After individual fibrinogen chains are translated, fibrinogen assembly occurs stepwise. Single chains assemble first into A\u03b1-\u03b3 and B\u03b2-\u03b3 precursors, then into A\u03b1\/B\u03b2\/\u03b3 half-molecules, and finally into hexameric complexes (A\u03b1\/B\u03b2\/\u03b3)2. Once fibrinogen is released into blood, it circulates until thrombin cleaves fibrinopeptides &hellip; <a href=\"https:\/\/www.med.unc.edu\/wolberglab\/scientific-images-2\/fibrinogen-synthesis-and-expression\/\" aria-label=\"Read more about Fibrinogen synthesis and expression\">Read more<\/a><\/p>\n"},"alt_text":"","media_type":"image","mime_type":"image\/jpeg","media_details":{"width":1280,"height":1021,"file":"2018\/04\/fibrinogen-synthesis-and-expression.jpeg","sizes":{"thumbnail":{"file":"fibrinogen-synthesis-and-expression-150x120.jpeg","width":150,"height":120,"mime_type":"image\/jpeg","source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression-150x120.jpeg"},"medium":{"file":"fibrinogen-synthesis-and-expression-300x239.jpeg","width":300,"height":239,"mime_type":"image\/jpeg","source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression-300x239.jpeg"},"medium_large":{"file":"fibrinogen-synthesis-and-expression-768x613.jpeg","width":768,"height":613,"mime_type":"image\/jpeg","source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression-768x613.jpeg"},"large":{"file":"fibrinogen-synthesis-and-expression-1024x817.jpeg","width":1024,"height":817,"mime_type":"image\/jpeg","source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression-1024x817.jpeg"},"magicbox":{"file":"fibrinogen-synthesis-and-expression-642x512.jpeg","width":642,"height":512,"mime_type":"image\/jpeg","source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression-642x512.jpeg"},"post_thumbnail":{"file":"fibrinogen-synthesis-and-expression-64x64.jpeg","width":64,"height":64,"mime_type":"image\/jpeg","source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression-64x64.jpeg"},"post_thumbshort":{"file":"fibrinogen-synthesis-and-expression-800x420.jpeg","width":800,"height":420,"mime_type":"image\/jpeg","source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression-800x420.jpeg"},"full":{"file":"fibrinogen-synthesis-and-expression.jpeg","width":1280,"height":1021,"mime_type":"image\/jpeg","source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression.jpeg"}},"image_meta":{"aperture":"0","credit":"asilver2","camera":"","caption":"Fibrinogen synthesis and expression. Fibrinogen synthesis is regulated by both transcriptional and translational mechanisms. After individual fibrinogen chains are translated, fibrinogen assembly occurs stepwise. Single chains assemble first into A\u03b1-\u03b3 and B\u03b2-\u03b3 precursors, then into A\u03b1\/B\u03b2\/\u03b3 half-molecules, and finally into hexameric complexes (A\u03b1\/B\u03b2\/\u03b3)2. Once fibrinogen is released into blood, it circulates until thrombin cleaves fibrinopeptides from the A\u03b1 and B\u03b2 chains (FpA and FpB, respectively) to form fibrin monomers. These monomers then polymerize in a half-staggered arrangement to form fibrin protofibrils and ultimately the fibrin network at a site of tissue injury.","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"Fibrinogen synthesis and expression","orientation":"0","keywords":[]}},"post":2219,"source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression.jpeg","_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/media\/2221","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/media"}],"about":[{"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/types\/attachment"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/users\/9746"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/comments?post=2221"}]}}