{"id":2222,"date":"2018-04-10T13:44:54","date_gmt":"2018-04-10T17:44:54","guid":{"rendered":"https:\/\/med.sites.unc.edu\/wolberglab\/files\/2018\/04\/fxiiia-cross-linking-during-fibrin-formation.jpeg"},"modified":"2018-04-10T13:46:38","modified_gmt":"2018-04-10T17:46:38","slug":"fxiiia-cross-linking-during-fibrin-formation","status":"inherit","type":"attachment","link":"https:\/\/www.med.unc.edu\/wolberglab\/scientific-images-2\/fxiiia-cross-linking-during-fibrin-formation\/","title":{"rendered":"FXIIIa cross-linking during fibrin formation"},"author":9746,"featured_media":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_links_to":"","_links_to_target":""},"class_list":["post-2222","attachment","type-attachment","status-inherit","hentry","odd"],"acf":[],"description":{"rendered":"<p class=\"attachment\"><a class=\"thumbnail img-thumbnail\" href='https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fxiiia-cross-linking-during-fibrin-formation.jpeg'><img loading=\"lazy\" decoding=\"async\" width=\"270\" height=\"300\" src=\"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fxiiia-cross-linking-during-fibrin-formation-270x300.jpeg\" class=\"attachment-medium size-medium\" alt=\"\" srcset=\"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fxiiia-cross-linking-during-fibrin-formation-270x300.jpeg 270w, https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fxiiia-cross-linking-during-fibrin-formation-150x167.jpeg 150w, https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fxiiia-cross-linking-during-fibrin-formation-461x512.jpeg 461w, https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fxiiia-cross-linking-during-fibrin-formation.jpeg 720w\" sizes=\"auto, (max-width: 270px) 100vw, 270px\" \/><\/a><\/p>\n<p>FXIIIa cross-linking during fibrin formation. Fibrinogen is a hexamer composed of 2 A\u03b1- (purple), 2 B\u03b2- (blue), and 2 \u03b3-chains (green). During coagulation, thrombin cleaves N-terminal fibrinopeptides from the A\u03b1- and B\u03b2-chains, producing fibrin monomers which polymerize into protofibrils and subsequently, fibers. FXIIIa increases clot stability by introducing \u03b5-N-(\u03b3-glutamyl)-lysyl cross-links between residues in the \u03b3- and \u03b1-chains of fibrin monomers within individual fibers. FXIIIa first introduces cross-links between \u03b3-chains (forming \u03b3-\u03b3 dimers) and subsequently between \u03b3- and \u03b1-chains (forming high-molecular-weight species [\u03b3-multimers, \u03b1-polymers, and \u03b1\u03b3-hybrids]).<\/p>\n"},"caption":{"rendered":"<p>FXIIIa cross-linking during fibrin formation. Fibrinogen is a hexamer composed of 2 A\u03b1- (purple), 2 B\u03b2- (blue), and 2 \u03b3-chains (green). During coagulation, thrombin cleaves N-terminal fibrinopeptides from the A\u03b1- and B\u03b2-chains, producing fibrin monomers which polymerize into protofibrils and subsequently, fibers. FXIIIa increases clot stability by introducing \u03b5-N-(\u03b3-glutamyl)-lysyl cross-links between residues in the \u03b3- &hellip; <a href=\"https:\/\/www.med.unc.edu\/wolberglab\/scientific-images-2\/fxiiia-cross-linking-during-fibrin-formation\/\" aria-label=\"Read more about FXIIIa cross-linking during fibrin formation\">Read more<\/a><\/p>\n"},"alt_text":"","media_type":"image","mime_type":"image\/jpeg","media_details":{"width":720,"height":800,"file":"2018\/04\/fxiiia-cross-linking-during-fibrin-formation.jpeg","sizes":{"thumbnail":{"file":"fxiiia-cross-linking-during-fibrin-formation-150x167.jpeg","width":150,"height":167,"mime_type":"image\/jpeg","source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fxiiia-cross-linking-during-fibrin-formation-150x167.jpeg"},"medium":{"file":"fxiiia-cross-linking-during-fibrin-formation-270x300.jpeg","width":270,"height":300,"mime_type":"image\/jpeg","source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fxiiia-cross-linking-during-fibrin-formation-270x300.jpeg"},"magicbox":{"file":"fxiiia-cross-linking-during-fibrin-formation-461x512.jpeg","width":461,"height":512,"mime_type":"image\/jpeg","source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fxiiia-cross-linking-during-fibrin-formation-461x512.jpeg"},"post_thumbnail":{"file":"fxiiia-cross-linking-during-fibrin-formation-64x64.jpeg","width":64,"height":64,"mime_type":"image\/jpeg","source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fxiiia-cross-linking-during-fibrin-formation-64x64.jpeg"},"post_thumbshort":{"file":"fxiiia-cross-linking-during-fibrin-formation-720x420.jpeg","width":720,"height":420,"mime_type":"image\/jpeg","source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fxiiia-cross-linking-during-fibrin-formation-720x420.jpeg"},"full":{"file":"fxiiia-cross-linking-during-fibrin-formation.jpeg","width":720,"height":800,"mime_type":"image\/jpeg","source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fxiiia-cross-linking-during-fibrin-formation.jpeg"}},"image_meta":{"aperture":"0","credit":"asilver2","camera":"","caption":"FXIIIa cross-linking during fibrin formation. Fibrinogen is a hexamer composed of 2 A\u03b1- (purple), 2 B\u03b2- (blue), and 2 \u03b3-chains (green). During coagulation, thrombin cleaves N-terminal fibrinopeptides from the A\u03b1- and B\u03b2-chains, producing fibrin monomers which polymerize into protofibrils and subsequently, fibers. FXIIIa increases clot stability by introducing \u03b5-N-(\u03b3-glutamyl)-lysyl cross-links between residues in the \u03b3- and \u03b1-chains of fibrin monomers within individual fibers. FXIIIa first introduces cross-links between \u03b3-chains (forming \u03b3-\u03b3 dimers) and subsequently between \u03b3- and \u03b1-chains (forming high-molecular-weight species [\u03b3-multimers, \u03b1-polymers, and \u03b1\u03b3-hybrids]).","created_timestamp":"0","copyright":"","focal_length":"0","iso":"0","shutter_speed":"0","title":"FXIIIa cross-linking during fibrin formation","orientation":"1","keywords":[]}},"post":2219,"source_url":"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fxiiia-cross-linking-during-fibrin-formation.jpeg","_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/media\/2222","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/media"}],"about":[{"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/types\/attachment"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/users\/9746"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/comments?post=2222"}]}}