{"id":2259,"date":"2010-09-22T14:20:00","date_gmt":"2010-09-22T18:20:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/wolberglab\/images\/virchows-triad\/"},"modified":"2018-04-10T14:03:54","modified_gmt":"2018-04-10T18:03:54","slug":"virchows-triad","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/wolberglab\/virchows-triad\/","title":{"rendered":"Virchow’s triad"},"content":{"rendered":"
\n

\"Contributions<\/p>\n

Contributions from cells, plasma, and blood flow (Virchow’s Triad) regulate fibrin
\nformation and therefore, fibrin network structure and stability.<\/b> Laser scanning confocal
\nmicrographs show re-calcified, platelet-poor plasma (hemophilia A, normal, and 200%
\nfibrinogen from left to right, respectively) spikedwith AlexaFluor-488\u2013labeled fibrinogen
\n(10 \u03bcg\/120 \u03bcL sample) and clotted by TF-bearing monocytes. Abnormally-coarse networks
\nof thick fibers are associated with an increased risk of bleeding, whereas overly-dense
\nnetworks of thin fibers are associated with an increased risk of thrombosis. Characterizing
\nthe specific mechanisms by which cells, plasma and blood flow regulate fibrin structure
\nand stability is critical for understanding hemostasis and identifying effective targets for
\nhemostatic and antithrombotic therapies.<\/p>\n

Wolberg AS, Aleman MM, Thrombosis Research<\/b> 2010 Apr;125 Suppl 1:S35-7<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Contributions from cells, plasma, and blood flow (Virchow’s Triad) regulate fibrin formation and therefore, fibrin network structure and stability. Laser scanning confocal micrographs show re-calcified, platelet-poor plasma (hemophilia A, normal, and 200% fibrinogen from left to right, respectively) spikedwith AlexaFluor-488\u2013labeled fibrinogen (10 \u03bcg\/120 \u03bcL sample) and clotted by TF-bearing monocytes. Abnormally-coarse networks of thick fibers … Read more<\/a><\/p>\n","protected":false},"author":9746,"featured_media":0,"parent":0,"menu_order":14,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2259","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"\nVirchow's triad - Wolberg Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/wolberglab\/virchows-triad\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Virchow's triad - Wolberg Lab\" \/>\n<meta property=\"og:description\" content=\"Contributions from cells, plasma, and blood flow (Virchow’s Triad) regulate fibrin formation and therefore, fibrin network structure and stability. 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