{"id":2259,"date":"2010-09-22T14:20:00","date_gmt":"2010-09-22T18:20:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/wolberglab\/images\/virchows-triad\/"},"modified":"2018-04-10T14:03:54","modified_gmt":"2018-04-10T18:03:54","slug":"virchows-triad","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/wolberglab\/virchows-triad\/","title":{"rendered":"Virchow&#8217;s triad"},"content":{"rendered":"<div>\n<p><img decoding=\"async\" class=\"image-inline\" title=\"Virchow triad\" src=\"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/Virchov.jpg\" alt=\"Contributions from cells, plasma, and blood flow (Virchow's Triad) regulate fibrin formation and therefore, fibrin network structure and stability\" \/><\/p>\n<p><b>Contributions from cells, plasma, and blood flow (Virchow&#8217;s Triad) regulate fibrin<br \/>\nformation and therefore, fibrin network structure and stability.<\/b> Laser scanning confocal<br \/>\nmicrographs show re-calcified, platelet-poor plasma (hemophilia A, normal, and 200%<br \/>\nfibrinogen from left to right, respectively) spikedwith AlexaFluor-488\u2013labeled fibrinogen<br \/>\n(10 \u03bcg\/120 \u03bcL sample) and clotted by TF-bearing monocytes. Abnormally-coarse networks<br \/>\nof thick fibers are associated with an increased risk of bleeding, whereas overly-dense<br \/>\nnetworks of thin fibers are associated with an increased risk of thrombosis. Characterizing<br \/>\nthe specific mechanisms by which cells, plasma and blood flow regulate fibrin structure<br \/>\nand stability is critical for understanding hemostasis and identifying effective targets for<br \/>\nhemostatic and antithrombotic therapies.<\/p>\n<p><a class=\"external-link\" href=\"http:\/\/dx.doi.org\/10.1213%2FANE.0b013e31823a088c\">Wolberg AS, Aleman MM, <b>Thrombosis Research<\/b> 2010 Apr;125 Suppl 1:S35-7<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Contributions from cells, plasma, and blood flow (Virchow&#8217;s Triad) regulate fibrin formation and therefore, fibrin network structure and stability. Laser scanning confocal micrographs show re-calcified, platelet-poor plasma (hemophilia A, normal, and 200% fibrinogen from left to right, respectively) spikedwith AlexaFluor-488\u2013labeled fibrinogen (10 \u03bcg\/120 \u03bcL sample) and clotted by TF-bearing monocytes. Abnormally-coarse networks of thick fibers &hellip; <a href=\"https:\/\/www.med.unc.edu\/wolberglab\/virchows-triad\/\" aria-label=\"Read more about Virchow&#8217;s triad\">Read more<\/a><\/p>\n","protected":false},"author":9746,"featured_media":0,"parent":0,"menu_order":14,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2259","page","type-page","status-publish","hentry","odd"],"acf":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/pages\/2259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/users\/9746"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/comments?post=2259"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/pages\/2259\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/media?parent=2259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}