{"id":2289,"date":"2017-07-07T18:55:00","date_gmt":"2017-07-07T22:55:00","guid":{"rendered":"https:\/\/med.sites.unc.edu\/wolberglab\/research-interests\/fibrinogen\/"},"modified":"2020-07-27T15:12:16","modified_gmt":"2020-07-27T19:12:16","slug":"fibrinogen","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/wolberglab\/research-interests\/fibrinogen\/","title":{"rendered":"Fibrinogen"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28228446\"><img loading=\"lazy\" decoding=\"async\" class=\"somoverlay image-inline alignright\" title=\"Fibrinogen synthesis and expression\" src=\"https:\/\/www.med.unc.edu\/wolberglab\/wp-content\/uploads\/sites\/645\/2018\/04\/fibrinogen-synthesis-and-expression.jpeg\" alt=\"Fibrinogen synthesis and expression. Fibrinogen synthesis is regulated by both transcriptional and translational mechanisms. After individual fibrinogen chains are translated, fibrinogen assembly occurs stepwise. Single chains assemble first into A\u03b1-\u03b3 and B\u03b2-\u03b3 precursors, then into A\u03b1\/B\u03b2\/\u03b3 half-molecules, and finally into hexameric complexes (A\u03b1\/B\u03b2\/\u03b3)2. Once fibrinogen is released into blood, it circulates until thrombin cleaves fibrinopeptides from the A\u03b1 and B\u03b2 chains (FpA and FpB, respectively) to form fibrin monomers. These monomers then polymerize in a half-staggered arrangement to form fibrin protofibrils and ultimately the fibrin network at a site of tissue injury.\" width=\"374\" height=\"299\" \/><\/a><\/p>\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/rth2.12191?af=R\">Fibrinogen<\/a> is a protein composed of 2 A\u03b1-chains, 2 B\u03b2-chains, and 2 \u03b3-chains that circulates in plasma. During clotting, fibrinogen is cleaved to fibrin by the enzyme <a class=\"external-link\" title=\"\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17208341\" target=\"_self\" rel=\"noopener noreferrer\">thrombin<\/a>. Fibrin monomers then polymerize into fibers, forming a network that reinforces the clot. Fibrin(ogen) plays a critical role in determining clot formation, structure, and stability, and is thus central to hemostasis and thrombosis. <a href=\"https:\/\/ashpublications.org\/blood\/article\/117\/18\/4953\/21432\/Causal-relationship-between-hyperfibrinogenemia\">Elevated levels of fibrinogen<\/a> in the blood lead to increased risk of venous thrombosis. Additionally, fibrin network structure affects risk of venous thrombosis. Multiple factors have been shown to modulate fibrin network <a class=\"external-link\" title=\"\" href=\"https:\/\/journals.lww.com\/co-hematology\/Abstract\/2012\/09000\/Determinants_of_fibrin_formation,_structure,_and.2.aspx\" target=\"_self\" rel=\"noopener noreferrer\">structure<\/a>; the effects of thrombin concentration have been especially well studied. In the presence of high thrombin concentrations, fibrin networks are dense and resistant to fibrinolysis, and in the presence of low thrombin concentrations, fibrin networks are less dense and are susceptible to fibrinolysis. We are interested in elucidating mechanisms leading to altered fibrin structure, as well as investigating the effects of altered fibrin structure on hemostasis and thrombosis.<b><\/b><\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Fibrinogen is a protein composed of 2 A\u03b1-chains, 2 B\u03b2-chains, and 2 \u03b3-chains that circulates in plasma. During clotting, fibrinogen is cleaved to fibrin by the enzyme thrombin. Fibrin monomers then polymerize into fibers, forming a network that reinforces the clot. Fibrin(ogen) plays a critical role in determining clot formation, structure, and stability, and &hellip; <a href=\"https:\/\/www.med.unc.edu\/wolberglab\/research-interests\/fibrinogen\/\" aria-label=\"Read more about Fibrinogen\">Read more<\/a><\/p>\n","protected":false},"author":49326,"featured_media":0,"parent":2218,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2289","page","type-page","status-publish","hentry","odd"],"acf":[],"_links_to":[],"_links_to_target":[],"_links":{"self":[{"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/pages\/2289","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/users\/49326"}],"replies":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/comments?post=2289"}],"version-history":[{"count":0,"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/pages\/2289\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/pages\/2218"}],"wp:attachment":[{"href":"https:\/\/www.med.unc.edu\/wolberglab\/wp-json\/wp\/v2\/media?parent=2289"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}