Optical Micro Imaging Technologies for Assessing Tissue Histology in vivo

BRIC Seminar Series -- Presented by Xingde Li, PhD -- Professor, Biomedical Engineering / Johns Hopkins University

When Dec 11, 2013
from 01:00 PM to 02:00 PM
Where 1131 Bioinformatics
Contact Name
Contact Phone 919-966-4397
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Abstract

This seminar will present our recent developments of high-resolution biophotonic imaging technologies, including optical coherence tomography (OCT) and multiphoton endomicroscopy. These technologies have shown significant translational potential for imaging tissue microanatomies in vivo at a resolution approaching or even at that of standard histopathology but without the need for tissue removal. Thus they can finction as a form of noninvasive “optical biopsy”, aiming to address unmet clinical needs in early disease detection, guidance of surgical intervention, and monitoring of treatment outcome. They physics principles, engineering challenges and solutions will be briefly discussed, including the development of advanced lasers, MEMS technology, fiber optics, and ultracompact, high-performance imaging optics. Representative applications of these high-resolution technologies will be presented, including cancer detection, airway physiology assessment, pattern birth risk assessment, and intra-operative guidance for neurosurgery. Other potential applications towards basic research such as functional neuroimaging on awake or freely walking animals will also be discussed.

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