{"id":2324,"date":"2014-09-19T22:10:21","date_gmt":"2014-09-19T22:10:21","guid":{"rendered":"http:\/\/zebrafish.web.unc.edu\/?page_id=200"},"modified":"2024-02-27T11:30:58","modified_gmt":"2024-02-27T16:30:58","slug":"existing-strains","status":"publish","type":"page","link":"https:\/\/www.med.unc.edu\/zebrafish\/gene-editing\/existing-strains\/","title":{"rendered":"Existing Strains"},"content":{"rendered":"<p>Having selected zebrafish, <em>Danio rerio, <\/em>as the optimal model system, it is prudent to determine whether there are existing strains with modification to the gene of interest.<\/p>\n<ol type=\"1\">\n<li>Find the ortholog of the gene in zebrafish. Since zebrafish are teleosts, having undergone whole genome duplication, it may be necessary to find any paralogs as well. Search NCBI&#8217;s <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/homologene\">HomoloGene<\/a> or <a href=\"https:\/\/useast.ensembl.org\/Danio_rerio\/Info\/Index\">Esembl<\/a>.<\/li>\n<li>Define what type of genetic modification is desired\n<ol>\n<li><a href=\"http:\/\/www.addgene.org\/genome_engineering\/\">Gene targeted<\/a><\/li>\n<li><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=17937395\">Transgenic<\/a><\/li>\n<\/ol>\n<\/li>\n<li>Determine whether the desired gene modification exists<\/li>\n<\/ol>\n<p><strong>Search the following databases:<\/strong><\/p>\n<ul>\n<li>ZFIN&#8217;s <a href=\"http:\/\/zfin.org\/action\/fish\/search\">General Fish Database<\/a><\/li>\n<li>The Sanger Institute&#8217;s Zebrafish Mutation Project <a href=\"http:\/\/www.sanger.ac.uk\/Projects\/D_rerio\/zmp\/\">Homepage<\/a> &amp; <a href=\"http:\/\/www.sanger.ac.uk\/cgi-bin\/Projects\/D_rerio\/zmp\/browse.pl\">Fish Knockout Database<\/a><\/li>\n<li>The Fred Hutchinson Cancer Research Center Moens TILLing Project <a href=\"https:\/\/research.fredhutch.org\/moens\/en.html\">Homepage.<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Having selected zebrafish, Danio rerio, as the optimal model system, it is prudent to determine whether there are existing strains with modification to the gene of interest. Find the ortholog of the gene in zebrafish. Since zebrafish are teleosts, having undergone whole genome duplication, it may be necessary to find any paralogs as well. Search &hellip; <a href=\"https:\/\/www.med.unc.edu\/zebrafish\/gene-editing\/existing-strains\/\" aria-label=\"Read more about Existing Strains\">Read more<\/a><\/p>\n","protected":false},"author":81071,"featured_media":0,"parent":2320,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"layout":"","cellInformation":"","apiCallInformation":"","footnotes":"","_links_to":"","_links_to_target":""},"class_list":["post-2324","page","type-page","status-publish","hentry","odd"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Existing Strains - Zebrafish Aquaculture Core<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.med.unc.edu\/zebrafish\/gene-editing\/existing-strains\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Existing Strains - Zebrafish Aquaculture Core\" \/>\n<meta property=\"og:description\" content=\"Having selected zebrafish, Danio rerio, as the optimal model system, it is prudent to determine whether there are existing strains with modification to the gene of interest. Find the ortholog of the gene in zebrafish. Since zebrafish are teleosts, having undergone whole genome duplication, it may be necessary to find any paralogs as well. Search &hellip; Read more\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.med.unc.edu\/zebrafish\/gene-editing\/existing-strains\/\" \/>\n<meta property=\"og:site_name\" content=\"Zebrafish Aquaculture Core\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/unczac\" \/>\n<meta property=\"article:modified_time\" content=\"2024-02-27T16:30:58+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.med.unc.edu\/zebrafish\/gene-editing\/existing-strains\/\",\"url\":\"https:\/\/www.med.unc.edu\/zebrafish\/gene-editing\/existing-strains\/\",\"name\":\"Existing Strains - Zebrafish Aquaculture Core\",\"isPartOf\":{\"@id\":\"https:\/\/www.med.unc.edu\/zebrafish\/#website\"},\"datePublished\":\"2014-09-19T22:10:21+00:00\",\"dateModified\":\"2024-02-27T16:30:58+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.med.unc.edu\/zebrafish\/gene-editing\/existing-strains\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.med.unc.edu\/zebrafish\/gene-editing\/existing-strains\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.med.unc.edu\/zebrafish\/gene-editing\/existing-strains\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.med.unc.edu\/zebrafish\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Gene Editing\",\"item\":\"https:\/\/www.med.unc.edu\/zebrafish\/genetic-engineering\/model-benefits\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Existing Strains\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.med.unc.edu\/zebrafish\/#website\",\"url\":\"https:\/\/www.med.unc.edu\/zebrafish\/\",\"name\":\"Zebrafish Aquaculture Core\",\"description\":\" \",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.med.unc.edu\/zebrafish\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Existing Strains - Zebrafish Aquaculture Core","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.med.unc.edu\/zebrafish\/gene-editing\/existing-strains\/","og_locale":"en_US","og_type":"article","og_title":"Existing Strains - Zebrafish Aquaculture Core","og_description":"Having selected zebrafish, Danio rerio, as the optimal model system, it is prudent to determine whether there are existing strains with modification to the gene of interest. Find the ortholog of the gene in zebrafish. Since zebrafish are teleosts, having undergone whole genome duplication, it may be necessary to find any paralogs as well. 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