In the area of immunology, the research within the Department focuses on clinical, basic science, and translational research. The scientists engaged in this work are highly collaborative and include faculty from Departments within the Schools of Medicine, Dentistry, and Public Health. Individual research programs reflect this faculty diversity, with topics including lymphocyte development and tolerance, lymphocyte function, autoimmune diseases, transplantation, innate immunity, and the immune response to bacteria and viruses.
A diverse collection of pathogenic bacteria, fungi, and protozoa are studied by these scientists. This field is interdisciplinary in scope and draws from a wide range of expertise and technology; consequently, the faculty includes members of the Departments of Medicine, Pathology, Epidemiology, Pharmacology, Biology, and Chemistry. Research efforts include studies of molecular mechanisms of pathogen-host interactions, evasion and manipulation of host immunity, signal transduction, regulation of gene expression, drug resistance, vaccine development and epidemiology of infectious diseases.
Viral infections in humans constitute a huge worldwide disease burden, and Department faculty study many established and emerging viruses including HIV, and members of the herpesvirus, flavivirus, alphavirus, orthomyxovirus, and coronavirus families. This highly collaborative group includes labs that are located in the Schools of Medicine, Dentistry, Public Health, as well as the College of Arts and Sciences. Their research programs reflect broad interests in vaccine/vector development, viral pathogenesis, host innate responses to infection, viral oncogenesis, virus evolution and basic aspects of replication.