Selected Publications

Click here for publications during affiliation with University of North Carolina, Chapel hill

1. Focal adhesion kinase regulates smooth muscle cell recruitment to the developing vasculature. Cheng Z, Sundberg-Smith LJ, Mangiante LE, Sayers RL, Hakim ZS, Musunuri S, Maguire CT, Majesky MW, Zhou Z, Mack CP, Taylor JM. Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2193-202. Epub 2011 Jul 14

2.  Formin homology domain-containing protein 1 regulates smooth muscle cell phenotype.

Staus DP, Blaker AL, Medlin MD, Taylor JM, Mack CP.

Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):360-7. Epub 2010 Nov 24.

PMID:21106951

3.  Sphingosine 1-phosphate receptor 2 signals through leukemia-associated RhoGEF (LARG), to promote smooth muscle cell differentiation.

Medlin MD, Staus DP, Dubash AD, Taylor JM, Mack CP.

Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1779-86. Epub 2010 Aug 11.

PMID:20702813

4.  Focal adhesion kinase is essential for cardiac looping and multichamber heart formation.

Doherty JT, Conlon FL, Mack CP, Taylor JM. Genesis. 2010 Aug;48(8):492-504.

PMID:20572259

5.  PKA-dependent phosphorylation of serum response factor inhibits smooth muscle-specific gene expression.

Blaker AL, Taylor JM, Mack CP. Arterioscler Thromb Vasc Biol. 2009 Dec;29(12):2153-60. Epub 2009 Sep 24.

PMID: 19778940

6.  Transient expression of FRNK reveals stage-specific requirement for focal adhesion kinase activity in cardiac growth.

DiMichele LA, Hakim ZS, Sayers RL, Rojas M, Schwartz RJ, Mack CP, Taylor JM.

Circ Res. 2009 May 22;104(10):1201-8. Epub 2009 Apr 16.

PMID: 19372463

7.  FAK regulates cardiomyocyte survival following ischemia/reperfusion.

Hakim ZS, DiMichele LA, Rojas M, Meredith D, Mack CP, Taylor JM.

J Mol Cell Cardiol. 2009 Feb;46(2):241-8. Epub 2008 Nov 5.

PMID: 19028502

8.  FRNK expression promotes smooth muscle cell maturation during vascular development and after vascular injury.

Sayers RL, Sundberg-Smith LJ, Rojas M, Hayasaka H, Parsons JT, Mack CP, Taylor JM.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2115-22. Epub 2008 Sep 11.

PMID: 18787183

9.  Regulation of myocardin factor protein stability by the LIM-only protein FHL2.

Hinson JS, Medlin MD, Taylor JM, Mack CP.

Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1067-H1075. Epub 2008 Jun 27.

PMID: 18586895

10.  The LIM protein leupaxin is enriched in smooth muscle and functions as an serum response factor cofactor to induce smooth muscle cell gene transcription.

Sundberg-Smith LJ, DiMichele LA, Sayers RL, Mack CP, Taylor JM.

Circ Res. 2008 Jun 20;102(12):1502-11. Epub 2008 May 22.

PMID: 18497331

11.  The histone demethylase, Jmjd1a, interacts with the myocardin factors to regulate SMC differentiation marker gene expression.

Lockman K, Taylor JM, Mack CP.

Circ Res. 2007 Dec 7;101(12):e115-23. Epub 2007 Nov 8.

PMID: 17991879

12.  Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment.

Hakim ZS, DiMichele LA, Doherty JT, Homeister JW, Beggs HE, Reichardt LF, Schwartz RJ, Brackhan J, Smithies O, Mack CP, Taylor JM.

Mol Cell Biol. 2007 Aug;27(15):5352-64. Epub 2007 May 25.

PMID:  17526730

13.  Diaphanous 1 and 2 regulate smooth muscle cell differentiation by activating the myocardin-related transcription factors.

Staus DP, Blaker AL, Taylor JM, Mack CP.

Arterioscler Thromb Vasc Biol. 2007 Mar;27(3):478-86. Epub 2006 Dec 14.

PMID:17170370 [PubMed - indexed for MEDLINE] Free Article Related citations

14.  Smooth muscle cell-specific transcription is regulated by nuclear localization of the myocardin-related transcription factors.

Hinson JS, Medlin MD, Lockman K, Taylor JM, Mack CP.

Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H1170-80. Epub 2006 Sep 22.

PMID: 16997888

15.  Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy.

DiMichele LA, Doherty JT, Rojas M, Beggs HE, Reichardt LF, Mack CP, Taylor JM.

Circ Res. 2006 Sep 15;99(6):636-45. Epub 2006 Aug 10.

PMID: 16902179

16.  Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation.

Sundberg-Smith LJ, Doherty JT, Mack CP, Taylor JM.

J Biol Chem. 2005 Jan 21;280(3):2055-64. Epub 2004 Nov 12.

PMID: 15542607

17. Sphingosine 1-phosphate stimulates smooth muscle cell differentiation and proliferation by activating separate serum response factor co-factors.

Lockman K, Hinson JS, Medlin MD, Morris D, Taylor JM, Mack CP.

J Biol Chem. 2004 Oct 8;279(41):42422-30. Epub 2004 Aug 3.

PMID: 15292266

18.  An endogenous inhibitor of focal adhesion kinase blocks Rac1/JNK but not Ras/ERK-dependent signaling in vascular smooth muscle cells.

Sundberg LJ, Galante LM, Bill HM, Mack CP, Taylor JM.

J Biol Chem. 2003 Aug 8;278(32):29783-91. Epub 2003 Jun 2.

PMID: 12782622

19.  Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells.

Taylor JM, Mack CP, Nolan K, Regan CP, Owens GK, Parsons JT.

Mol Cell Biol. 2001 Mar;21(5):1565-72.

PMID: 11238893

20. Characterization of graf, the GTPase-activating protein for rho associated with focal adhesion kinase. Phosphorylation and possible regulation by mitogen-activated protein kinase.

Taylor JM, Hildebrand JD, Mack CP, Cox ME, Parsons JT.

J Biol Chem. 1998 Apr 3;273(14):8063-70.

PMID: 9525907