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Bowles Center for Alcohol Studies

PUBLICATIONS

Publications from the NADIA Consortium. Additional information on an individual study is available by contacting the corresponding author.

2020:

  1. Coleman LG Jr, Zou J, Crews FT. Microglial depletion and repopulation in brain slice culture normalizes sensitized proinflammatory signaling. J Neuroinflammation. 2020 Jan 18;17(1):27. doi: 10.1186/s12974-019-1678-y. PMID: 31954398.
  2. Healey KL, Kibble S, Hodges S, Reissner KJ, Testen A, Wills TA, Acheson SK, Siemsen BM, McFaddin JA, Scofield MD, Swartzwelder HS. Enduring alterations in hippocampal astrocyte-synaptic proximity following adolescent alcohol exposure: reversal by gabapentin. Neural Regen Res. 2020: 15(8):1496-1501. doi:10.4103/1673-5374.274339.
  3. Healey KL, Landin JD, Dubester K, Kibbie S, Marquardt K, Brutman JN, Davis JF, Swartzwelder HS, Chandler LJ. Effects of ethanol on plasma ghrelin levels in the rat during early and late adolescence. 2020 Jan 7:pii: S0741-8329(19)30042-4. doi.org/10.1016/j.alcohol.2019.12.006. Epub 2020 Jan 7. PMID: pending.
  4. Landin JD, Gore-Langton JK, Varlinskaya EI, Spear LP, Werner DF. General Anesthetic Exposure During Early Adolescence Persistently Alters Ethanol Responses. Alcohol Clin Exp Res. 2020 Feb 18. doi: 10.1111/acer.14291. [Epub ahead of print]. PMID: 32068904.
  5. Macht V, Crews FT, Vetreno RP. Neuroimmune and epigenetic mechanisms underlying persistent loss of hippocampal neurogenesis following adolescent intermittent ethanol exposure. Curr Opin Pharmacol. 2019 Nov 25;50:9-16. doi: 10.1016/j.coph.2019.10.007. [Epub ahead of print] Review. PMID: 31778865.
  6. Pandey SC, Bohnsack JP. Alcohol Makes Its Epigenetic Marks. Cell Metab. 2020 Feb 4;31(2):213-214. doi: 10.1016/j.cmet.2020.01.008. PMID: 32023443.
  7. Peng Q, Wilhelmsen KC, Ehlers CL. Common genetic substrates of alcohol and substance use disorder severity revealed by pleiotropy detection against GWAS catalog in two populations. Addict Biol. 2020 Feb 6:e12877. doi: 10.1111/adb.12877. [Epub ahead of print] PMID:32027075.
  8. Spear LP. Timing eclipses amount: The critical importance of intermittency in alcohol exposure effects. Alcohol Clin Exp Res. 2020 Feb 13. doi: 10.1111/acer.14307. [Epub ahead of print] Review. PMID: 32056231.
  9. Straka BC, Gaither SE, Acheson SK, Swartzwelder HS. “Mixed” drinking motivations: A comparison of majority, multiracial, and minority college students.  Social Psychological and Personality Science. doi.org/10.1177/1948550619883294. Epub 2019 Nov 19. PMID: pending.
  10. Varlinskaya EI, Hosová D, Towner T, Werner DF, Spear LP. Effects of chronic intermittent ethanol exposure during early and late adolescence on anxiety-like behaviors and behavioral flexibility in adulthood. Behav Brain Res. 2020 Jan 27;378:112292. doi: 10.1016/j.bbr.2019.112292. Epub 2019 Oct 15. PMID: 31626849.

2019:

  1. Bohnsack JP, Teppen T, Kyzar EJ, Dzitoyeva S, Pandey SC. The lncRNA BDNF-AS is an epigenetic regulator in the human amygdala in early onset alcohol use disorders. Transl Psychiatry. 2019 Feb 6;9(1):34. doi: 10.1038/s41398-019-0367-z. PMID: 30728347; PMCID: PMC6365546.
  2. Crews FT, Robinson DL, Chandler LJ, Ehlers CL, Mulholland PJ, Pandey SC, Rodd ZA, Spear LP, Swartzwelder HS, Vetreno RP. Mechanisms of persistent neurobiological changes following adolescent alcohol exposure: NADIA consortium findings. Alcohol Clin Exp Res. 2019 Sep;43(9):1806-1822. doi: 10.1111/acer.14154. Epub 2019 Aug 14. PMID: 31335972; PMCID: pending.
  3. Dannenhoffer CA, Hosova D, Dang S, Dang U, Spear LP. Critical variables to be considered when attempting to estimate blood ethanol concentratin in rats from g/kg exposure data. BioRxiv. 2019 Mar 20. doi:https://doi.org/10.1101/582361.
  4. Dannenhoffer CA, Spear LP. Excitatory/inhibitory balance across ontogeny contribute to age–specific behavioral outcomes of ethanol-like challenge in conditioned taste aversion. Developmental Psychobiology. 2019 May 13. doi:10.1002/dev128642019 PMID: 31087376; PMCID: pending.
  5. Dulman RS, Auta J, Teppen T, Pandey SC. Acute ethanol produces ataxia and induces Fmr1 expression via histone modifications in the rat cerebellum. Alcohol Clin Exp Res. 2019 Jun;43(6):1191-1198. doi: 10.1111/acer.14044. Epub 2019 May 14. PMID: 30969437; PMCID: PMC6613579
  6. Ehlers CL, Benedict J, Wills DN, Sanchez-Alavez M. Effect of a dual orexin receptor antagonist (DORA-12) on sleep and event-related oscillations in adult rats exposed to chronic intermittent ethanol vapor and protracted withdrawal during adolescence. 2019 Oct 28. doi: 10.1007/s00213-019-05371-4. PMID: 31659377; PMCID: pending.
  7. Ehlers CL, Phillips E, Wills D, Benedict J, Sanchez-Alavez M. Phase locking of event-related oscillations is decreased in both young adult humans and rats with a history of adolescent alcohol exposure. Addict Biol. 2019 Mar 18. doi: 10.1111/adb.12732. [Epub ahead of print] PMID: 30884076; PMCID: pending.
  8. Glover EJ, Starr EM, Chao Y, Jhou TC, Chandler LJ. Inhibition of the rostromedial tegmental nucleus reverses alcohol withdrawal-induced anxiety-like behavior. 2019 May 6. doi: 10.1038/s41386-019-0406-8. [Epub ahead of print]. PMID: 31060041; PMCID: pending.
  9. Gorka SM, Teppen T, Radoman M, Phan KL, Pandey SC. Human plasma BDNF is associated with amygdala-prefrontal cortex functional connectivity and problem drinking behaviors. Int J Neuropsychopharmacology. 2019 Nov 13. pii: pyz057. doi: 10.1093/ijnp/pyz057. [Epub ahead of print]. PMID: pending; PMCID: pending.
  10. Hauser SR, Deehan GA Jr, Knight CP, Waeiss RA, Truitt WA, Johnson PL, Bell RL, McBride WJ, Rodd ZA. Conditioned stimuli affect ethanol-seeking by female alcohol-preferring (P) rats: the role of repeated-deprivations, cue-pretreatment, and cue-temporal intervals. Psychopharmacology (Berl). 2019 Sep;236(9):2835-2846. doi: 10.1007/s00213-019-05264-6. Epub 2019 May 16. PMID: 31093721; PMCID: PMC6697605.
  11. Hauser SR, Knight CP, Truitt WA, Waeiss RA, Holt IS, Carvajal GB, Bell RL, Rodd ZA. Adolescent intermittent ethanol increases the sensitivity to the reinforcing properties of ethanol and the expression of select cholinergic and dopaminergic genes within the posterior ventral tegmental area. Alcohol Clin Exp Res. 2019 Sep;43(9):1937-1948. doi: 10.1111/acer.14150. Epub 2019 Aug 21. PMID: 31329298; PMCID: pending.
  12. Hosová D, Spear LP. Voluntary elevated ethanol consumption in adolescent Sprague-Dawley rats: Procedural contributors and age-specificity. 2019 Aug;78:1-12. doi: 10.1016/j.alcohol.2019.02.003. Epub 2019 Feb 22. PMID: 30797832; PMCID: PMC6612312.
  13. Khatri D, Laroche G, Grant ML, Jones VM, Vetreno RP, Crews FT, Mukhopadhyay S. Acute ethanol inhibition of adult hippocampal neurogenesis involves CB1 cannabinoid receptor signaling. Alcohol Clin Exp Res. 2018 Apr;42(4):718-726. doi: 10.1111/acer.13608. Epub 2018 Mar 7. PMID: 29417597; PMCID: PMC6042509.
  14. Kim EU, Dannenhoffer CA, Varlinskaya EI, Spear LP. Adolescent intermittent ethanol exposure: Effects on pubertal development, novelty seeking and social interaction in adulthood. 2019 March;75:19-29. doi: 10.1016/j.alcohol.2018.05.002. PMID: 30326391; PMCID: pending.
  15. Kyzar EJ, Bohnsack JP, Zhang H, Pandey SC. MicroRNA-137 drives epigenetic reprogramming in the adult amygdala and behavioral changes after adolescent alcohol exposure. 2019 Nov 18. pii: ENEURO.0401-19.2019. doi: 10.1523/ENEURO.0401-19.2019. [Epub ahead of print].
  16. Landin JD, Palac M, Carter JM, Dzumaga Y, Santerre-Anderson JL, Fernandez GM, Savage LM, Varlinskaya EI, Spear LP, Moore SD, Swartzwelder HS, Fleming RL, Werner DF. General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity. Neuropharmacology. 2019 May 15;150:153-163. doi: 10.1016/j.neuropharm.2019.03.022. Epub 2019 Mar 26. PMID: 30926450; PMCID: pending.
  17. Lawrimore CJ, Coleman LG, Crews FT. Ethanol induces interferon expression in neurons via TRAIL: role of astrocyte-to-neuron signaling. Psychopharmacology (Berl). 2019 Jan 4. doi: 10.1007/s00213-018-5153-8. [Epub ahead of print]. PMID: 30926450.
  18. Lawrimore CJ, Coleman LG, Zou J, Crews FT. Ethanol induction of innate immune signals across BV2 microglia and SH-SY5& neuroblastoma involves induction of IL-4 and IL-13. Brain Sci. 2019;9:228. doi: 10.3390/brainsci9090228. Epub 2019 Sept 10. PMID: 31510019; PMCID: PMC6770440.
  19. Nentwig TB, Starr EM, Chandler LJ, Glover EJ. Absence of compulsive drinking phenotype in adult male rats exposed to ethanol in a binge-like pattern during adolescence. 2019 Sep;79:93-103. doi: 10.1016/j.alcohol.2019.01.006. Epub 2019 Jan 18. PMID: 30664983; PMCID: PMC6639162.
  20. Randall PA, Vetreno RP, Makhijani VH, Crews FT, Besheer J. The toll-like receptor 3 agonist Poly(I:C) induces rapid and lasting changes in gene expression related to glutamatergic function and increases ethanol self-administration in rats. Alcohol Clin Exp Res. 2019 Jan;43(1):48-60. doi: 10.1111/acer.13919. Epub 2018 Dec 16. PMID: 30403408; PMCID: PMC6541929.
  21. Sakharkar AJ, Kyzar EJ, Gavin DP, Zhang H, Chen Y, Krishnan HR, Grayson DR, Pandey SC. Altered amygdala DNA methylation mechanisms after adolescent alcohol exposure contribute to adult anxiety and alcohol drinking. 2019 Oct;157:107679. doi: 10.1016/j.neuropharm.2019.107679. Epub 2019 Jun 20. PMID: 31229451; PMCID: PMC6681823.
  22. Sanchez-Alavez M, Benedict J, Wills DN, Ehlers CL. Effect of suvorexant on event-related oscillations and EEG sleep in rats exposed to chronic intermittent ethanol vapor and protracted withdrawal. 2019 Apr 1;42(4). pii: zsz020. doi: 10.1093/sleep/zsz020. PMID: 30715515; PMCID: PMC6448295.
  23. Sanchez-Alavez M, Nguyen W, Mori S, Wills DN, Otero D, Ehlers CL, Conti B. Time course of brain and blood cytokine/chemokine levels following adolescent intermittent ethanol exposure and withdrawal in rats. Alcohol Clin Exp Res. [In press]
  24. Sanchez-Alavez M, Nguyen W, Mori S, Wills DN, Otero D, Ehlers CL, Conti B. Time course of microglia activation and brain and blood cytokine/chemokine levels following chronic ethanol exposure and protracted withdrawal in rats. 2019 May;76:37-45. doi: 10.1016/j.alcohol.2018.07.005. Epub 2018 Jul 17. PMID: 30554034; PMCID: PMC6336521.
  25. Schepis TS, Acheson S, Zapp D, Swartzwelder HS. Alcohol use and consequences in matriculating US college students by prescription stimulant/opioid nonmedical misuse status. Addict Behav. 2019 Nov;98:106026. doi: 10.1016/j.addbeh.2019.06.015. Epub 2019 Jun 18. doi: 10.1016/j.addbeh.2019.06.015. PMID: 31415970; PMCID: PMC6754780.
  26. Swartzwelder HS, Healey K, Liu W, Dubester K, Miller KM, Crews FT. Changes in neuroimmune and neuronal death markers after adolescent alcohol exposure in rats are reversed by Sci Rep (Berlin). 2019 Aug 20;9(1):12110. doi: 10.1038/s41598-019-47039-1. PMID: 31431637; PMCID: PMC6702347.
  27. Testen A, Ali M, Sexton HG, Hodges S, Dubester K, Reissner KJ, Swartzwelder HS, Risher ML. Region-specific differences in morphometric features and synaptic colocalization of astrocytes during development. 2019 Feb 21;400:98-109. doi: 10.1016/j.neuroscience.2018.12.044. Epub 2018 Dec 29. PMID: 30599266; PMCID: PMC6361709.
  28. Towner TT, Fager M, Spear LP. Adolescent, but not adult, Sprague-Dawley rats display goal-directed responding after reward devaluation. Dev Psychobiol. 2019 Sep 6. doi: 10.1002/dev.21912. [Epub ahead of print]. PMID: 31493315; PMCID: pending.
  29. Varlinskaya EI, Hosova D, Towner TT, Werner DF, Spear LP. (2019). Effects of chronic intermittent ethanol exposure during early and late adolescence on anxiety-like behaviors and behavioral flexibility in adulthood.  Behavioural Brain Research, 378(27): 112292.  doi:10.1016/j.bbr.2019.112292 PMID: 31626849.
  30. Vetreno RP, Bohnsack JP, Kusumo H, Liu W, Pandey SC, Crews FT. Neuroimmune and epigenetic involvement in adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons: restoration with voluntary exercise. Addict Biol. 2019 Feb 18. doi: 10.1111/adb.12731. [Epub ahead of print] PMID: 30779268; PMCID: PMC6698434.
  31. Vetreno RP, Massey V, Crews FT. Long lasting microbial dysbiosis and altered enteric neurotransmitters in adult rats following adolescent binge ethanol exposure. Addiction Biology. 2019 Dec 27:e12869. doi: 10.1111/adb.12869. [Epub ahead of print]. PMID: 31880056.
  32. Waeiss RA, Knight CP, Hauser SR, Pratt LA, McBride WJ, Rodd ZA. Therapeutic challenges for concurrent ethanol and nicotine consumption: naltrexone and varenicline fail to alter simultaneous ethanol and nicotine intake by female alcohol-preferring (P) rats. Psychopharmacology (Berl). 2019 Jun;236(6):1887-1900. doi: 10.1007/s00213-019-5174-y. Epub 2019 Feb 13. PMID: 30758525; PMCID: PMC6606358.

2018:

  1. Amodeo LR, Wills DN, Sanchez-Alavez M, Nguyen W, Conti B, Ehlers CL. Intermittent voluntary ethanol consumption combined with ethanol vapor exposure during adolescence increases drinking and alters other behaviors in adulthood in female and male rats. Alcohol. 2018 Dec;73:57-66. doi: 10.1016/j.alcohol.2018.04.003. Epub 2018 Apr 18. PMID: 30293056; PMCID: PMC6193864.
  2. Bohnsack JP, Hughes BA, O’Buckley TK, Edokpolor K, Besheer J, Morrow AL. Histone deacetylases mediate GABAA receptor expression, physiology, and behavioral maladaptations in rat models of alcohol dependence. Neuropsychopharmacology. 2018 Jun;43(7):1518-1529. doi: 10.1038/s41386-018-0034-8. Epub 2018 Feb 27. PMID: 29520058; PMCID: PMC5983537.
  3. Boule LA, Ju C, Agudelo M, Parira T, Cannon A, Davis B, Eby J, Cresci G, Samuelson DR, Shukla P, Alrefai WA, Sureshchandra S, Pandey SC, Schnabl B, Curtis BJ, Wyatt TA, Choudhry MA, Kovacs EJ. Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2018 Feb;66:35-43. doi: 10.1016/j.alcohol.2017.07.005. Epub 2017 Sep 23. PMID: 29127885; PMCID: PMC5743588.
  4. Boutros N, Der-Avakian A, Kesby JP, Lee S, Markou A, Semenova S. Effects of adolescent alcohol exposure on stress-induced reward deficits, brain CRF, monoamines and glutamate in adult rats. 2018;235:737. https://doi.org/10.1007/s00213-017-4789-0; PMID: 29181815.
  5. Broadwater MA, Lee SH, Yu Y, Zhu H, Crews FT, Robinson DL, Shih YI. Adolescent alcohol exposure decreases frontostriatal resting-state functional connectivity in adulthood. Addict Biol. 2018 Mar;23(2):810-823. doi: 10.1111/adb.12530. Epub 2017 Jul 9. PMID: 28691248; PMCID: PMC5760482.
  6. Coleman LG Jr, Crews FT. Innate immune signaling and alcohol use disorders. Handb Exp Pharmacol. 2018;248:369-396. doi: 10.1007/164_2018_92. Erratum in: Handb Exp Pharmacol. 2018;248:621. PMID: 29500721; PMCID: PMC6120815.
  7. Coleman LG Jr, Zou J, Qin L, Crews FT. HMGB1/IL-1β complexes regulate neuroimmune responses in alcoholism. Brain Behav Immun. 2018 Aug;72:61-77. doi: 10.1016/j.bbi.2017.10.027. Epub 2017 Nov 2. PMID: 29102800; PMCID: PMC5932292.
  8. Crews FT, Vetreno RP. Stress and alcohol priming of brain toll-like receptor signaling in alcohol use disorder. Alcohol Alcohol. 2018 Nov; 53(6): 639–641. Published online 2018 Oct 19. doi: 10.1093/alcalc/agy061 PMID: 30346466; PMCID: PMC6676785.
  9. Dannenhoffer CA, Kim EU, Saalfield J, Werner DF, Varlinskaya EI, Spear LP. Oxytocin and vasopressin modulation of social anxiety following adolescent intermittent ethanol exposure. Psychopharmacology (Berl). 2018 Oct;235(10):3065-3077. doi: 10.1007/s00213-018-5003-8. Epub 2018 Aug 23. PMID: 30141056; PMCID: PMC6456069.
  10. Dannenhoffer CA, Varlinskaya EI, Spear LP. Effects of AMPA receptor antagonist, NBQX, and extrasynaptic GABAA agonist, THIP, on social behavior of adolescent and adult rats. Physiol Behav. 2018 Oct 1;194:212-217. doi: 10.1016/j.physbeh.2018.05.024. Epub 2018 May 22. PMID: 29800636; PMCID: pending.
  11. Deehan GA Jr, Hauser SR, Getachew B, Waeiss RA, Engleman EA, Knight CP, McBride WJ, Truitt WA, Bell RL, Rodd ZA. Selective breeding for high alcohol consumption and response to nicotine: locomotor activity, dopaminergic in the mesolimbic system, and innate genetic differences in male and female alcohol-preferring, non-preferring, and replicate lines of high-alcohol drinking and low-alcohol drinking rats. Psychopharmacology (Berl). 2018 Sep;235(9):2755-2769. doi: 10.1007/s00213-018-4970-0. Epub 2018 Jul 24. PMID: 30043172; PMCID: PMC6655552.
  12. Dong E, Guidotti A, Zhang H, Pandey SC. Prenatal stress leads to chromatin and synaptic remodeling and excessive alcohol intake comorbid with anxiety-like behaviors in adult offspring. 2018 Sep 15;140:76-85. doi: 10.1016/j.neuropharm.2018.07.010. Epub 2018 Aug 4. PMID: 30016666; PMCID: PMC6499375
  13. Ehlers CL, Sanchez-Alavez M, Wills D. Effect of gabapentin on sleep and delta and theta EEG power in adult rats exposed to chronic intermittent ethanol vapor and protracted withdrawal during adolescence. Psychopharmacology (Berl). 2018 Jun;235(6):1783-1791. doi: 10.1007/s00213-018-4888-6. Epub 2018 Mar 27. PMID: 29589069; PMCID: PMC5949268.
  14. Hiller-Sturmhofel S, Spear LP. Binge drinking’s effects on the developing brain – Animal models. Alcohol Res. 2018 Jan;39(1):e1-10. PMID: 30557150; PMCID: PMC6104958.
  15. Kao YJ, Oyarzabal EA, Zhang H, Faber JE, Shih YI. Role of genetic variation in collateral circulation in the evolution of acute stroke: a multimodal magnetic resonance imaging study. Stroke. 2017 Mar;48(3):754-761. doi: 10.1161/STROKEAHA.116.015878. Epub 2017 Feb 10. PMID: 28188261; PMCID: PMC5380467.
  16. Massey VL, Qin L, Cabezas J, Caballeria J, Sancho-Bru P, Bataller R, Crews FT. TLR7-let-7 signaling contributes to ethanol-induced hephepatic inflammatory response in mice and in alcoholic hepatitis. Alcohol Clin Exp Res. 2018 Nov;42(11):2107-2122. doi: 10.1111/acer.13871. Epub 2018 Sep 10. PMID: 30103265; PMCID: PMC6282707.
  17. Mulholland PJ, Teppen TL, Miller KM, Sexton HG, Pandey SC, Swartzwelder HS. Donepezil reverses dendritic spine morphology adaptations and Fmr1 epigenetic modifications in hippocampus of adult rats after adolescent alcohol exposure. Alcohol Clin Exp Res. 2018 Apr;42(4):706-717. doi: 10.1111/acer.13599. Epub 2018 Feb 15. PMID: 29336496; PMCID: PMC5903436.
  18. Ruby CL, Paye G, Fabi JL, Zhang J, Risinger MO, Palmer KN, Verbanes NM, D’Angelo A, Watts TM, Mabe L, Swartzwelder HS. Sex differences in photic entrainment and sensitivity to ethanol-induced chronodisruption in adult mice after adolescent intermittent ethanol exposure. Alcohol Clin Exp Res. 2018 Nov;42(11):2144-2159. doi: 10.1111/acer.13867. Epub 2018 Sep 2. PMID: 30102762; PMCID: PMC6214762.
  19. Sanchez-Alavez M, Wills DN, Amodeo L, Ehlers CL. Effect of gabapentin on sleep and event-related oscillations (EROs) in rats exposed to chronic intermittent ethanol vapor and protracted withdrawal. Alcohol Clin Exp Res. 2018 Mar; 42(3): 624–633. Published online 2018 Jan 31. doi: 10.1111/acer.13588. PMID: 29286538; PMCID: PMC5832602.
  20. Spear LP. Effects of adolescent alcohol consumption on the brain and behavior. Nat Rev Neurosci. 2018 Apr;19(4):197-214. doi: 10.1038/nrn.2018.10. Epub 2018 Feb 15. PMID:29467489; PMCID: pending.
  21. Vetreno RP, Crews FT. Adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons and neuroimmune activation are prevented by exercise and indomethacin. PLoS One. 2018 Oct 8;13(10):e0204500. doi: 10.1371/journal.pone.0204500. eCollection 2018. PMID: 30296276; PMCID: PMC6175501.
  22. Vetreno RP, Lawrimore CJ, Rowsey PJ, Crews FT. Persistent adult neuroimmune activation and loss of hippocampal neurogenesis following adolescent ethanol exposure: blockade by exercise and the anti-inflammatory drug indomethacin. Front Neurosci. 2018 Mar 28;12:200. doi: 10.3389/fnins.2018.00200. eCollection 2018. PMID: 29643762; PMCID: PMC5882830.
  23. Zhang H, Kyzar EJ, Bohnsack JP, Kokare DM, Teppen T, Pandey SC. Adolescent alcohol exposure epigenetically regulates CREB signaling in the adult amygdala. Sci Rep. 2018 Jul 10;8(1):10376. doi: 10.1038/s41598-018-28415-9. PMID: 29991681; PMCID: PMC6039491

2017:

  1. Amodeo LR, Kneiber D, Wills DN, Ehlers CL. Alcohol drinking during adolescence increases consumptive responses to alcohol in adulthood in Wistar rats. Alcohol. 2017 Mar;59:43-51. doi: 10.1016/j.alcohol.2016.12.002. Epub 2017 Feb 7. PMID: 28187948; PMCID: PMC5358807.
  2. Amodeo LR, Wills DN, Ehlers CL. Acute low-level alcohol consumption reduces phase locking of event-related oscillations in rodents. Behav Brain Res. 2017 Jul 14;330:25-29. doi: 10.1016/j.bbr.2017.05.007. Epub 2017 May 8. PMID: 28495609; PMCID: PMC5521819.
  3. Barker JM, Bryant KG, Osborne JI, Chandler LJ. Age and sex interact to mediate the effects of intermittent, high-dose ethanol exposure on behavioral flexibility. Front Pharmacol. 2017 Jul 7;8:450. doi: 10.3389/fphar.2017.00450. PMID: 28736526; PMCID: PMC5500662.
  4. Berkel TD, Pandey SC. Emerging role of epigenetic mechanisms in alcohol addiction. Alcohol Clin Exp Res. 2017 Apr;41(4):666-680. doi: 10.1111/acer.13338. Epub 2017 Feb 18. PMID: 28111764; PMCID: PMC5378655.
  5. Boutros N, Der-Avakian A, Markou A, Semenova S. Effects of early life stress and adolescent ethanol exposure on adult cognitive performance in the 5-choice serial reaction time task in Wistar male rats. Psychopharmacology (Berl). 2017 May;234(9-10):1549-1556. doi: 10.1007/s00213-017-4555-3. Epub 2017 Feb 14. PMID: 28197651; PMCID: pending.
  6. Centanni SW, Burnett EJ, Trantham-Davidson H, Chandler LJ. Loss of δ-GABAA receptor-mediated tonic currents in the adult prelimbic cortex following adolescent alcohol exposure. Addict Biol. 2017 May;22(3):616-628. doi: 10.1111/adb.12353. Epub 2016 Jan 24. PMID: 26804056; PMCID: PMC4958607.
  7. Coleman LG Jr, Zou J, Crews FT. Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7. J Neuroinflammation. 2017 Jan 25;14(1):22. doi: 10.1186/s12974-017-0799-4. PMID: 28118842; PMCID: PMC5264311.
  8. Crews FT, Walter TJ, Coleman LG Jr, Vetreno RP. Toll-like receptor signaling and stages of addiction. Psychopharmacology (Berl). 2017 May;234(9-10):1483-1498. doi: 10.1007/s00213-017-4560-6. Epub 2017 Feb 17. PMID: 28210782; PMCID: PMC5420377.
  9. Gass JT, McGonigal JT, Chandler LJ. Deficits in the extinction of ethanol-seeking behavior following chronic intermittent ethanol exposure are attenuated with positive allosteric modulation of mGlu5. Neuropharmacology. 2017 Feb;113(Pt A):198-205. doi: 10.1016/j.neuropharm.2016.10.005. Epub 2016 Oct 8. PMID: 27725153; PMCID: PMC5148675.
  10. Hosová D, Spear LP. Voluntary binge consumption of ethanol in a sweetened, chocolate-flavored solution by male and female adolescent Sprague Dawley rats. Alcohol Clin Exp Res. 2017 Mar;41(3):541-550. doi: 10.1111/acer.13315. Epub 2017 Feb 14. PMID: 28195335; PMCID: PMC5499524.
  11. Kokare DM, Kyzar EJ, Zhang H, Sakharkar AJ, Pandey SC. Adolescent alcohol exposure-induced changes in alpha-melanocyte stimulating hormone and neuropeptide Y pathways via histone acetylation in the brain during adulthood. Int J Neuropsychopharmacol. 2017 Sep 1;20(9):758-768. doi: 10.1093/ijnp/pyx041. PMID: 28575455; PMCID: PMC5581492.
  12. Kruse LC, Schindler AG, Williams RG, Weber SJ, Clark JJ. Maladaptive decision making in Adults with h History of adolescent alcohol use, in a preclinical model, is attributable to the compromised assignment of incentive value during stimulus-reward learning. Front Behav Neurosci. 2017 Jul 25;11:134. doi: 10.3389/fnbeh.2017.00134. PMID: 28790900; PMCID: PMC5524919; PMCID: pending.
  13. Kyzar EJ, Zhang H, Sakharkar AJ, Pandey SC. Adolescent alcohol exposure alters lysine demethylase 1 (LSD1) expression and histone methylation in the amygdala during adulthood. Addict Biol. 2017 Sep;22(5):1191-1204. doi: 10.1111/adb.12404. Epub 2016 May 15. PMID: 27183824; PMCID: PMC5110402.
  14. Lawrimore CJ, Crews FT. Ethanol, TLR3, and TLR4 agonists have unique innate immune responses in neuron-like SH-SY5Y and microglia-like BV2. Alcohol Clin Exp Res. 2017 May;41(5):939-954. doi: 10.1111/acer.13368. Epub 2017 Mar 30. PMID: 28273337; PMCID: PMC5407472.
  15. Liu W, Crews FT. Persistent decreases in adult subventricular and hippocampal neurogenesis following adolescent intermittent ethanol exposure. Front Behav Neurosci. 2017 Aug 14;11:151. doi: 10.3389/fnbeh.2017.00151. PMID: 28855864; PMCID: PMC5557743.
  16. Madayag AC, Stringfield SJ, Reissner KJ, Boettiger CA, Robinson DL. Sex and adolescent ethanol exposure influence Pavlovian conditioned approach. Alcohol Clin Exp Res. 2017 Apr;41(4):846-856. doi: 10.1111/acer.13354. Epub 2017 Mar 13. PMID: 28196273; PMCID: PMC5419304.
  17. Mannes ZL, Burrell LE 2nd, Dunne EM, Hearn LE, Whitehead NE. Contextualizing psychosocial determinants of alcohol use by age cohorts adults living with HIV, ages 50 and older. J Assoc Nurses AIDS Care. 2017 Mar-Apr;28(2):279-288. doi: 10.1016/j.jana.2016.11.005. Epub 2016 Nov 28. PMID: 28003102; PMCID: PMC5329126.
  18. Miller KM, Risher ML, Acheson SK, Darlow M, Sexton HG, Schramm-Sapyta N, Swartzwelder HS. Behavioral inefficiency on a risky decision-making task in adulthood after adolescent intermittent ethanol exposure in rats. Sci Rep. 2017 Jul 5;7(1):4680. doi: 10.1038/s41598-017-04704-7. PMID: 28680108; PMCID: PMC5498633.
  19. Palmisano M, Pandey SC. Epigenetic mechanisms of alcoholism and stress-related disorders. Alcohol. 2017 May;60:7-18. doi: 10.1016/j.alcohol.2017.01.001. Epub 2017 Mar 3. PMID: 28477725; PMCID: PMC5464725.
  20. Pandey SC, Kyzar EJ, Zhang H. Epigenetic basis of the dark side of alcohol addiction. Neuropharmacology. 2017 Aug 1;122:74-84. doi: 10.1016/j.neuropharm.2017.02.002. Epub 2017 Feb 4. PMID: 28174112; PMCID: PMC5479721.
  21. Ruby CL, Palmer KN, Zhang J, Risinger MO, Butkowski MA, Swartzwelder HS. Differential sensitivity to ethanol-induced circadian rhythm disruption in adolescent and adult mice. Alcohol Clin Exp Res. 2017 Jan;41(1):187-196. doi: 10.1111/acer.13275. Epub 2016 Dec 20. PMID: 27997028; PMCID: PMC5205578.
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  23. Trantham-Davidson H, Centanni SW, Garr SC, New NN, Mulholland PJ, Gass JT, Glover EJ, Floresco SB, Crews FT, Krishnan HR, Pandey SC, Chandler LJ. Binge-like alcohol exposure during adolescence disrupts dopaminergic neurotransmission in the adult prelimbic cortex. 2017 Apr;42(5):1024-1036. doi: 10.1038/npp.2016.190. Epub 2016 Sep 13. PMID: 27620551; PMCID: PMC5506791.
  24. Tupler LA, Zapp D, DeJong W, Ali M, O’Rourke S, Looney J, Swartzwelder HS. Alcohol-related blackouts, negative alcohol-related cnsequences, and motivations for drinking reported by newly matriculating transgender college s Alcohol Clin Exp Res. 2017 May;41(5):1012-1023. doi: 10.1111/acer.13358. Epub 2017 Mar 21. PMID: 28324915; PMCID: PMC5404959.
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  27. Walter TJ, Crews FT. Microglial depletion alters the brain neuroimmune response to acute binge ethanol withdrawal. J Neuroinflammation. 2017 Apr 20;14(1):86. doi: 10.1186/s12974-017-0856-z. PMID: 28427424; PMCID: PMC5439231.
  28. Walter TJ, Vetreno RP, Crews FT. Alcohol and stress activation of microglia and neurons: brain regional effects. Alcohol Clin Exp Res. 2017 Dec;41(12):2066-2081. doi: 10.1111/acer.13511. Epub 2017 Nov 8. PMID: 28941277; PMCID: PMC5725687.

2016:

  1. Albaugh DL, Salzwedel A, Van Den Berge N, Gao W, Stuber GD, Shih YY. Functional magnetic resonance imaging of electrical and optogenetic deep brain stimulation at the rat nucleus accumbens. Sci Rep. 2016 Sep 7;6:31613. doi: 10.1038/srep31613. PMID: 27601003; PMCID: PMC5013271.
  2. Allen CD, Grigoleit JS, Hong J, Bae S, Vaughan J, Lee S. Exposure to alcohol during adolescence exerts long-term effects on stress response and the adult brain stress circuits. Neuroscience. 2016 Dec 17;339:64-71. doi: 10.1016/j.neuroscience.2016.09.031. Epub 2016 Sep 28. PMID: 27687801; PMCID: PMC5354126.
  3. Barker JM, Lench DH, Chandler LJ. Reversal of alcohol dependence-induced deficits in cue-guided behavior via mGluR2/3 signaling in mice. Psychopharmacology (Berl). 2016 Jan;233(2):235-42. doi: 10.1007/s00213-015-4101-0. Epub 2015 Oct 8. PMID: 26449720; PMCID: PMC4703438.
  4. Boutros N, Der-Avakian A, Semenova S, Lee S, Markou A. Risky choice and brain CRF after adolescent ethanol vapor exposure and social stress in adulthood. Behav Brain Res. 2016 Sep 15;311:160-166. doi: 10.1016/j.bbr.2016.05.038. Epub 2016 May 20. PMID: 27217101; PMCID: PMC5253236.
  5. Boutros N, Semenova S, Markou A. Adolescent alcohol exposure decreased sensitivity to nicotine in adult Wistar rats. Addict Biol. 2016 Jul;21(4):826-34. doi: 10.1111/adb.12263. Epub 2015 May 7. PMID: 25950618; PMCID: PMC4636981.
  6. Burnett EJ, Chandler LJ, Trantham-Davidson H. Glutamatergic plasticity and alcohol dependence-induced alterations in reward, affect and cognition. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Feb 4;65:309-20. doi: 10.1016/j.pnpbp.2015.08.012. Epub 2015 Sep 1. PMID: 26341050; PMCID: PMC4679411.
  7. Crews FT, Vetreno RP, Broadwater MA, Robinson DL. Adolescent alcohol exposure persistently impacts adult neurobiology and behavior. Pharmacol Rev. 2016 Oct;68(4):1074-1109. doi: 10.1124/pr.115.012138. PMID: 27677720; PMCID: PMC5050442.
  8. Doremus-Fitzwater TL, Spear LP. Reward-centricity and attenuated aversions: An adolescent phenotype emerging from studies in laboratory animals. Neurosci Biobehav Rev. 2016 Nov;70:121-134. doi: 10.1016/j.neubiorev.2016.08.015. Epub 2016 Aug 11. PMID: 27524639; PMCID: PMC5612441.
  9. Glover EJ, McDougle MJ, Siegel GS, Jhou TC, Chandler LJ. Role for the rostromedial tegmental nucleus in signaling the aversive properties of alcohol. Alcohol Clin Exp Res. 2016 Aug;40(8):1651-61. doi: 10.1111/acer.13140. Epub 2016 Jul 8. PMID: 27388762; PMCID: PMC4961514.
  10. Guizzetti M, Davies DL, Egli M, Finn DA, Molina P, Regunathan S, Robinson DL, Sohrabji F. Sex and the lab: an alcohol-focused commentary on the NIH initiative to balance sex in cell and animal studies. Alcohol Clin Exp Res. 2016 Jun;40(6):1182-91. doi: 10.1111/acer.13072. Epub 2016 May 7. PMID: 27154003; PMCID: PMC4889570.
  11. Kyzar EJ, Banerjee R. Targeted epigenetic modulation of gene expression in the brain. J Neurosci. 2016 Sep 7;36(36):9283-5. doi: 10.1523/JNEUROSCI.1990-16.2016. PMID: 27605604; PMCID: PMC5013181.
  12. Kyzar EJ, Floreani C, Teppen TL, Pandey SC. Adolescent alcohol exposure: burden of epigenetic reprogramming, synaptic remodeling, and adult psychopathology. Front Neurosci. 2016 May 31;10:222. doi: 10.3389/fnins.2016.00222. PMID: 27303256; PMCID: PMC4885838.
  13. Lee J, Kim SH, Oguz I, Styner M. Enhanced cortical thickness measurements for rodent brains via Lagrangian-based RK4 streamline computation. Proc SPIE Int Soc Opt Eng. 2016 Feb 27;9784:97840B. doi: 10.1117/12.2216420. Epub 2016 Mar 21. PMID: 27065047; PMCID: PMC4825173.
  14. Lee J, Kim SH, Styner M. Multi-object model-based multi-atlas segmentation for rodent brains using dense discrete correspondences. Proc SPIE Int Soc Opt Eng. 2016 Feb 27;9784:97840Q. doi: 10.1117/12.2217709. Epub 2016 Mar 21. PMID: 27065200; PMCID: PMC4825178.
  15. Mulholland PJ, Chandler LJ, Kalivas PW. Signals from the fourth dimension regulate drug relapse. Trends Neurosci. 2016 Jul;39(7):472-485. doi: 10.1016/j.tins.2016.04.007. Epub 2016 May 10. PMID: 27173064; PMCID: PMC4930682.
  16. Pandey SC. A critical role of brain-derived neurotrophic factor in alcohol consumption. Biol Psychiatry. 2016 Mar 15;79(6):427-9. doi: 10.1016/j.biopsych.2015.12.020. PMID: 26893193; PMCID: PMC4945157.
  17. Sakharkar AJ, Vetreno RP, Zhang H, Kokare DM, Crews FT, Pandey SC. A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood. Brain Struct Funct. 2016 Dec;221(9):4691-4703. doi: 10.1007/s00429-016-1196-y. Epub 2016 Mar 3. PMID: 26941165; PMCID: PMC5010799.
  18. Sanchez-Alavez M, Ehlers CL. Event-related oscillations (ERO) during an active discrimination task: Effects of lesions of the nucleus basalis magnocellularis. Int J Psychophysiol. 2016 May;103:53-61. doi: 10.1016/j.ijpsycho.2015.02.010. Epub 2015 Feb 7. PMID: 25660307; PMCID: PMC4529390.
  19. Schindler AG, Soden ME, Zweifel LS, Clark JJ. Reversal of alcohol-induced dysregulation in dopamine network dynamics may rescue maladaptive decision-making. J Neurosci. 2016 Mar 30;36(13):3698-708. doi: 10.1523/JNEUROSCI.4394-15.2016. PMID: 27030756; PMCID: PMC4812130.
  20. Shnitko TA, Spear LP, Robinson DL. Adolescent binge-like alcohol alters sensitivity to acute alcohol effects on dopamine release in the nucleus accumbens of adult rats. Psychopharmacology (Berl). 2016 Feb;233(3):361-71. PMID: 26487039; PMCID: PMC4840100.
  21. Shnitko TA, Taylor SC, Stringfield SJ, Zandy SL, Cofresí RU, Doherty JM, Lynch WB, Boettiger CA, Gonzales RA, Robinson DL. Acute phenylalanine/tyrosine depletion of phasic dopamine in the rat brain. Psychopharmacology (Berl). 2016 Jun;233(11):2045-2054. doi: 10.1007/s00213-016-4259-0. Epub 2016 Mar 5. PMID: 26944052; PMCID: PMC4864125.
  22. Spear LP. A developmental biological perspective of adolescent substance abuse: animal models. In S. Brown & R.A. Zucker (Eds.) The Oxford Handbook of Adolescence Substance Abuse. New York, NY: Oxford University Press. 2016. doi: 10.1093/oxfordhb/9780199735662.001.0001
  23. Spear LP. Consequences of adolescent use of alcohol and other drugs: studies using rodent models. Neurosci Biobehav Rev. 2016 Nov;70:228-243. doi: 10.1016/j.neubiorev.2016.07.026. Epub 2016 Jul 30. PMID: 27484868; PMCID: PMC5074861.
  24. Spear LP, Silveri MM. Special Issue on the Adolescent Brain. Neurosci Biobehav Rev. 2016 Nov;70:1-3. doi: 10.1016/j.neubiorev.2016.08.004. Epub 2016 Aug 4. PMID: 27497719; PMCID: PMC5605811.
  25. Swartzwelder HS, Risher ML, Miller KM, Colbran RJ, Winder DG, Wills TA. Changes in the adult GluN2B associated proteome following adolescent intermittent ethanol exposure. PLoS One. 2016 May 23;11(5):e0155951. doi: 10.1371/journal.pone.0155951. eCollection 2016. PMID: 27213757; PMCID: PMC4877005.
  26. Teppen TL, Krishnan HR, Zhang H, Sakharkar AJ, Pandey SC. The potential role of amygdaloid microRNA-494 in alcohol-induced anxiolysis. Biol Psychiatry. 2016 Nov 1;80(9):711-719. doi: 10.1016/j.biopsych.2015.10.028. Epub 2015 Nov 26. PMID: 26786313; PMCID: PMC4882267.
  27. Vetreno RP, Patel Y, Patel U, Walter TJ, Crews FT. Adolescent intermittent ethanol reduces serotonin expression in the adult raphe nucleus and upregulates innate immune expression that is prevented by exercise. Brain Behav Immun. 2017 Feb;60:333-345. doi: 10.1016/j.bbi.2016.09.018. Epub 2016 Sep 16. PMID: 27647531; PMCID: PMC5215774.
  28. Vetreno RP, Yaxley R, Paniagua B, Crews FT. Diffusion tensor imaging reveals adolescent binge ethanol-induced brain structural integrity alterations in adult rats that correlate with behavioral dysfunction. Addict Biol. 2016 Jul;21(4):939-53. doi: 10.1111/adb.12232. Epub 2015 Feb 11. PMID: 25678360; PMCID: PMC4532660.

2015:

  1. Barber RC, Phillips NR, Tilson JL, Huebinger RM, Shewale SJ, Koenig JL, Mitchel JS, O’Bryant SE, Waring SC, Diaz-Arrastia R, Chasse S, Wilhelmsen KC; Alzheimer’s Disease Neuroimaging Initiative; Texas Alzheimer’s Research and Care Consortium. Can genetic analysis of putative blood Alzheimer’s disease biomarkers lead to identification of susceptibility loci? PLoS One. 2015 Dec 1;10(12):e0142360. doi: 10.1371/journal.pone.0142360. PMID: 26625115; PMCID: PMC4666664
  2. Blum K, Febo M, Smith DE, Roy AK 3rd, Demetrovics Z, Cronjé FJ, Femino J, Agan G, Fratantonio JL, Pandey SC, Badgaiyan RD, Gold MS. Neurogenetic and epigenetic correlates of adolescent predisposition to and risk for addictive behaviors as a function of prefrontal cortex dysregulation. J Child Adolesc Psychopharmacol. 2015 May;25(4):286-92. doi: 10.1089/cap.2014.0146. Epub 2015 Apr 28. PMID: 25919973; PMCID: PMC4442554.
  3. Crews FT, Vetreno RP. Mechanisms of neuroimmune gene induction in alcoholism. Psychopharmacology (Berl). 2016 May;233(9):1543-57. doi: 10.1007/s00213-015-3906-1. Epub 2015 Mar 20. PMID: 25787746; PMCID: PMC4828484.
  4. Cui C, Noronha A, Warren KR, Koob GF, Sinha R, Thakkar M, Matochik J, Crews FT, Chandler LJ, Pfefferbaum A, Becker HC, Lovinger D, Everitt BJ, Egli M, Mandyam CD, Fein G, Potenza MN, Harris RA, Grant KA, Roberto M, Meyerhoff DJ, Sullivan EV. Brain pathways to recovery from alcohol dependence. Alcohol. 2015 Aug;49(5):435-52. doi: 10.1016/j.alcohol.2015.04.006. Epub 2015 May 14. PMID: 26074423; PMCID: PMC4468789.
  5. Kyzar EJ, Pandey SC. Molecular mechanisms of synaptic remodeling in alcoholism. Neurosci Lett. 2015 Aug 5;601:11-9. doi: 10.1016/j.neulet.2015.01.051. Epub 2015 Jan 23. PMID: 25623036; PMCID: PMC4506731.
  6. Liu W, Crews FT. Adolescent intermittent ethanol exposure enhances ethanol activation of the nucleus accumbens while blunting the prefrontal cortex responses in adult rat. Neuroscience. 2015 May 7;293:92-108. doi: 10.1016/j.neuroscience.2015.02.014. Epub 2015 Feb 26. PMID: 25727639; PMCID: PMC4821202.
  7. Lopez MF, Laber K. Impact of social isolation and enriched environment during adolescence on voluntary ethanol intake and anxiety in C57BL/6J mice. Physiol Behav. 2015 Sep 1;148:151-6. doi: 10.1016/j.physbeh.2014.11.012. Epub 2014 Nov 8. PMID: 25446196; PMCID: PMC4425642.
  8. Pandey SC, Sakharkar AJ, Tang L, Zhang H. Potential role of adolescent alcohol exposure-induced amygdaloid histone modifications in anxiety and alcohol intake during adulthood. Neurobiol Dis. 2015 Oct;82:607-619. doi: 10.1016/j.nbd.2015.03.019. Epub 2015 Mar 24. PMID: 25814047; PMCID: PMC4581895.
  9. Risher ML, Fleming RL, Risher WC, Miller KM, Klein RC, Wills T, Acheson SK, Moore SD, Wilson WA, Eroglu C, Swartzwelder HS. Adolescent intermittent alcohol exposure: persistence of structural and functional hippocampal abnormalities into adulthood. Alcohol Clin Exp Res. 2015 Jun;39(6):989-97. doi: 10.1111/acer.12725. Epub 2015 Apr 27. PMID: 25916839; PMCID: PMC4452443.
  10. Risher ML, Sexton HG, Risher WC, Wilson WA, Fleming RL, Madison RD, Moore SD, Eroglu C, Swartzwelder HS. Adolescent intermittent alcohol exposure: dysregulation of thrombospondins and synapse formation are associated with decreased neuronal density in the adult hippocampus. Alcohol Clin Exp Res. 2015 Dec;39(12):2403-13. doi: 10.1111/acer.12913. Epub 2015 Nov 5. Erratum in: Alcohol Clin Exp Res. 2016 Aug;40(8):1794. PMID: 26537975; PMCID: PMC4712076.
  11. Saalfield J, Spear L. Consequences of repeated ethanol exposure during early or late adolescence on conditioned taste aversions in rats. Dev Cogn Neurosci. 2015 Dec;16:174-182. doi: 10.1016/j.dcn.2015.01.004. Epub 2015 Jan 23. PMID: 25698309; PMCID: PMC4512940.
  12. Spear LP. Adolescent alcohol exposure: Are there separable vulnerable periods within adolescence? Physiol Behav. 2015 Sep 1;148:122-30. doi: 10.1016/j.physbeh.2015.01.027. Epub 2015 Jan 23. PMID: 25624108; PMCID: PMC4484315.
  13. Swartzwelder HS, Acheson SK, Miller KM, Sexton HG, Liu W, Crews FT, Risher ML. Adolescent intermittent alcohol exposure: deficits in object recognition memory and forebrain cholinergic markers. PLoS One. 2015 Nov 3;10(11):e0140042. doi: 10.1371/journal.pone.0140042. eCollection 2015. PMID: 26529506; PMCID: PMC4631346.
  14. Trantham-Davidson H, Chandler LJ. Alcohol-induced alterations in dopamine modulation of prefrontal activity. 2015 Dec;49(8):773-9. doi: 10.1016/j.alcohol.2015.09.001. Epub 2015 Oct 23. PMID: 26558348; PMCID: PMC4691370.
  15. Varlinskaya EI, Spear LP. Social consequences of ethanol: Impact of age, stress, and prior history of ethanol exposure. Physiol Behav. 2015 Sep 1;148:145-50. doi: 10.1016/j.physbeh.2014.11.062. Epub 2014 Nov 26. PMID: 25431835; PMCID: PMC4444396.
  16. Varlinskaya EI, Truxell EM, Spear LP. Sex differences in sensitivity to the social consequences of acute ethanol and social drinking during adolescence. Behav Brain Res. 2015 Apr 1;282:6-13. doi: 10.1016/j.bbr.2014.12.054. Epub 2014 Dec 31. PMID: 25557799; PMCID: PMC4323930.
  17. Varlinskaya EI, Truxell EM, Spear LP. Ethanol intake under social circumstances or alone in sprague-dawley rats: impact of age, sex, social activity, and social anxiety-like behavior. Alcohol Clin Exp Res. 2015 Jan;39(1):117-25. doi: 10.1111/acer.12604. PMID: 25623411; PMCID: PMC4308818.
  18. Vetreno RP, Crews FT. Binge ethanol exposure during adolescence leads to a persistent loss of neurogenesis in the dorsal and ventral hippocampus that is associated with impaired adult cognitive functioning. Front Neurosci. 2015 Feb 12;9:35. doi: 10.3389/fnins.2015.00035. eCollection 2015. PMID: 25729346; PMCID: PMC4325907.

2014:

  1. Barker JM, Taylor JR, Chandler LJ. A unifying model of the role of the infralimbic cortex in extinction and habits. Learn Mem. 2014 Aug 15;21(9):441-8. doi: 10.1101/lm.035501.114. PMID: 25128534; PMCID: PMC4138355.
  2. Boutros N, Semenova S, Liu W, Crews FT, Markou A. Adolescent intermittent ethanol exposure is associated with increased risky choice and decreased dopaminergic and cholinergic neuron markers in adult rats. Int J Neuropsychopharmacol. 2014 Oct 31;18(2):10.1093/ijnp/pyu003 pyu003. doi: 10.1093/ijnp/pyu003. PMID: 25612895; PMCID: PMC4368879.
  3. Boutros N, Semenova S, Markou A. Adolescent intermittent ethanol exposure diminishes anhedonia during ethanol withdrawal in adulthood. Eur Neuropsychopharmacol. 2014 Jun;24(6):856-64. doi: 10.1016/j.euroneuro.2014.01.022. Epub 2014 Feb 4. PMID: 24560005; PMCID: PMC4020966.
  4. Broadwater MA, Liu W, Crews FT, Spear LP. Persistent loss of hippocampal neurogenesis and increased cell death following adolescent, but not adult, chronic ethanol exposure. Dev Neurosci. 2014;36(3-4):297-305. doi: 10.1159/000362874. Epub 2014 Jun 27. PMID: 24993092; PMCID: PMC4125431.
  5. Broadwater MA, Spear LP. Tone conditioning potentiates rather than overshadows context fear in adult animals following adolescent ethanol exposure. Dev Psychobiol. 2014 Jul;56(5):1150-5. doi: 10.1002/dev.21186. Epub 2013 Dec 11. PMID: 24339140; PMCID: pending.
  6. Broadwater M, Spear LP. Consequences of adolescent or adult ethanol exposure on tone and context fear retention: effects of an acute ethanol challenge during conditioning. Alcohol Clin Exp Res. 2014 May;38(5):1454-60. doi: 10.1111/acer.12382. Epub 2014 Mar 3. PMID: 24588350; PMCID: PMC4745254.
  7. Centanni SW, Teppen T, Risher ML, Fleming RL, Moss JL, Acheson SK, Mulholland PJ, Pandey SC, Chandler LJ, Swartzwelder HS. Adolescent alcohol exposure alters GABAA receptor subunit expression in adult hippocampus. Alcohol Clin Exp Res. 2014 Nov;38(11):2800-8. doi: 10.1111/acer.12562. PMID: 25421517; PMCID: PMC4244607.
  8. Coleman LG Jr, Liu W, Oguz I, Styner M, Crews FT. Adolescent binge ethanol treatment alters adult brain regional volumes, cortical extracellular matrix protein and behavioral flexibility. Pharmacol Biochem Behav. 2014 Jan;116:142-51. doi: 10.1016/j.pbb.2013.11.021. Epub 2013 Nov 23. PMID: 24275185; PMCID: PMC3913047.
  9. Crews FT, Vetreno RP. Neuroimmune basis of alcoholic brain damage. Int Rev Neurobiol. 2014;118:315-57. doi: 10.1016/B978-0-12-801284-0.00010-5. PMID: 25175868; PMCID: PMC5765863.
  10. Desikan A, Wills DN, Ehlers CL. Ontogeny and adolescent alcohol exposure in Wistar rats: open field conflict, light/dark box and forced swim test. Pharmacol Biochem Behav. 2014 Jul;122:279-85. doi: 10.1016/j.pbb.2014.04.011. Epub 2014 Apr 29. PMID: 24785000; PMCID: PMC4105136; PMCID: pending.
  11. Ehlers CL, Desikan A, Wills DN. Event-related potential responses to the acute and chronic effects of alcohol in adolescent and adult Wistar rats. Alcohol Clin Exp Res. 2014 Mar;38(3):749-59. doi: 10.1111/acer.12299. Epub 2014 Jan 31. PMID: 24483322; PMCID: PMC4002286.
  12. Ehlers CL, Wills DN, Desikan A, Phillips E, Havstad J. Decreases in energy and increases in phase locking of event-related oscillations to auditory stimuli occur during adolescence in human and rodent brain. Dev Neurosci. 2014;36(3-4):175-95. doi: 10.1159/000358484. Epub 2014 May 9. PMID: 24819672; PMCID: PMC4125510.
  13. Gass JT, Glen WB Jr, McGonigal JT, Trantham-Davidson H, Lopez MF, Randall PK, Yaxley R, Floresco SB, Chandler LJ. Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood. Neuropsychopharmacology. 2014 Oct;39(11):2570-83. doi: 10.1038/npp.2014.109. Epub 2014 May 13. PMID: 24820536; PMCID: PMC4207336.
  14. Gass JT, Trantham-Davidson H, Kassab AS, Glen WB Jr, Olive MF, Chandler LJ. Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex. J Neurosci. 2014 May 28;34(22):7562-74. doi: 10.1523/JNEUROSCI.5616-12.2014. PMID: 24872560; PMCID: PMC4035518.
  15. Klein RC, Saini S, Risher ML, Acheson SK, Fleming RL, Sexton HG, Swartzwelder HS, Moore SD. Regional-specific effects of ovarian hormone loss on synaptic plasticity in adult human APOE targeted replacement mice. PLoS One. 2014 Apr 14;9(4):e94071. doi: 10.1371/journal.pone.0094071. PMID: 24732142; PMCID: PMC3986067.
  16. Krishnan HR, Sakharkar AJ, Teppen TL, Berkel TD, Pandey SC. The epigenetic landscape of alcoholism. Int Rev Neurobiol. 2014;115:75-116. doi: 10.1016/B978-0-12-801311-3.00003-2. PMID: 25131543; PMCID: PMC4337828.
  17. Lee J, Lyu I, Styner M. Multi-atlas segmentation with particle-based group-wise image registration. Proc SPIE Int Soc Opt Eng. 2014 Mar 21;9034:903447. doi: 10.1117/12.2043333. PMID: 25075158; PMCID: PMC4112129.
  18. Lopez MF, Becker HC, Chandler LJ. Repeated episodes of chronic intermittent ethanol promote insensitivity to devaluation of the reinforcing effect of ethanol. Alcohol. 2014 Nov;48(7):639-45. doi: 10.1016/j.alcohol.2014.09.002. Epub 2014 Sep 6. PMID: 25266936; PMCID: PMC4250386.
  19. McClory AJ, Spear LP. Effects of ethanol exposure during adolescence or in adulthood on Pavlovian conditioned approach in Sprague-Dawley rats. Alcohol. 2014 Dec;48(8):755-63. doi: 10.1016/j.alcohol.2014.05.006. Epub 2014 Sep 28. PMID: 25449366; PMCID: PMC4254554.
  20. Mejia-Toiber J, Boutros N, Markou A, Semenova S. Impulsive choice and anxiety-like behavior in adult rats exposed to chronic intermittent ethanol during adolescence and adulthood. Behav Brain Res. 2014 Jun 1;266:19-28. doi: 10.1016/j.bbr.2014.02.019. Epub 2014 Feb 22. PMID: 24566059; PMCID: PMC4005391.
  21. Morales M, Anderson RI, Spear LP, Varlinskaya EI. Effects of the kappa opioid receptor antagonist, nor-binaltorphimine, on ethanol intake: impact of age and sex. Dev Psychobiol. 2014 May;56(4):700-12. doi: 10.1002/dev.21137. Epub 2013 Jun 10. PMID: 23754134; PMCID: PMC4074415.
  22. Morales M, Schatz KC, Anderson RI, Spear LP, Varlinskaya EI. Conditioned taste aversion to ethanol in a social context: impact of age and sex. Behav Brain Res. 2014 Mar 15;261:323-7. doi: 10.1016/j.bbr.2013.12.048. Epub 2014 Jan 6. PMID: 24406726; PMCID: PMC3955706.
  23. Mulholland PJ, Spencer KB, Hu W, Kroener S, Chandler LJ. Neuroplasticity of A-type potassium channel complexes induced by chronic alcohol exposure enhances dendritic calcium transients in hippocampus. Psychopharmacology (Berl). 2015 Jun;232(11):1995-2006. doi: 10.1007/s00213-014-3835-4. Epub 2014 Dec 17. PMID: 25510858; PMCID: PMC4426211.
  24. Qin L, Crews FT. Focal thalamic degeneration from ethanol and thiamine deficiency is associated with neuroimmune gene induction, microglial activation, and lack of monocarboxylic acid transporters. Alcohol Clin Exp Res. 2014 Mar;38(3):657-71. doi: 10.1111/acer.12272. Epub 2013 Oct 11. PMID: 24117525; PMCID: PMC3959259.
  25. Sakharkar AJ, Tang L, Zhang H, Chen Y, Grayson DR, Pandey SC. Effects of acute ethanol exposure on anxiety measures and epigenetic modifiers in the extended amygdala of adolescent rats. Int J Neuropsychopharmacol. 2014 Dec;17(12):2057-67. doi: 10.1017/S1461145714001047. Epub 2014 Jun 26. PMID: 24968059; PMCID: PMC4213292.
  26. Sakharkar AJ, Zhang H, Tang L, Baxstrom K, Shi G, Moonat S, Pandey SC. Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours. Int J Neuropsychopharmacol. 2014 Aug;17(8):1207-20. doi: 10.1017/S1461145714000054. Epub 2014 Feb 17. PMID: 24528596; PMCID: PMC4140694.
  27. Sanchez-Alavez M, Robledo P, Wills DN, Havstad J, Ehlers CL. Cholinergic modulation of event-related oscillations (ERO). Brain Res. 2014 Apr 22; 1559: 11–25. Published online 2014 Mar 2. doi: 10.1016/j.brainres.2014.02.043. PMID: 24594019; PMCID: PMC4090032.
  28. Shnitko TA, Kennerly LC, Spear LP, Robinson DL. Ethanol reduces evoked dopamine release and slows clearance in the rat medial prefrontal cortex. Alcohol Clin Exp Res. 2014 Dec;38(12):2969-77. doi: 10.1111/acer.12587. PMID: 25581652; PMCID: PMC4293045.
  29. Shnitko TA, Robinson DL. Anatomical and pharmacological characterization of catecholamine transients in the medial prefrontal cortex evoked by ventral tegmental area stimulation. 2014 Apr;68(4):131-43. doi: 10.1002/syn.21723. Epub 2013 Nov 28. PMID: 24285555; PMCID: PMC4060446.
  30. Spear LP. Adolescents and alcohol: acute sensitivities, enhanced intake, and later consequences. Neurotoxicol Teratol. 2014 Jan-Feb;41:51-9. doi: 10.1016/j.ntt.2013.11.006. Epub 2013 Nov 26. PMID: 24291291; PMCID: PMC3943972.
  31. Spear LP, Swartzwelder HS. Adolescent alcohol exposure and persistence of adolescent-typical phenotypes into adulthood: a mini-review. Neurosci Biobehav Rev. 2014 Sep;45:1-8. doi: 10.1016/j.neubiorev.2014.04.012. Epub 2014 May 9. PMID: 24813805; PMCID: PMC4134704.
  32. Swartzwelder HS, Hogan A, Risher ML, Swartzwelder RA, Wilson WA, Acheson SK. Effect of sub-chronic intermittent ethanol exposure on spatial learning and ethanol sensitivity in adolescent and adult rats. 2014 Jun;48(4):353-60. doi: 10.1016/j.alcohol.2014.02.003. Epub 2014 Apr 12. PMID: 24795209; PMCID: PMC4084686.
  33. Trantham-Davidson H1, Burnett EJ, Gass JT, Lopez MF, Mulholland PJ, Centanni SW, Floresco SB, Chandler LJ. Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex. J Neurosci. 2014 Mar 5;34(10):3706-18. doi: 10.1523/JNEUROSCI.0623-13.2014. PMID: 24599469; PMCID: PMC3942586.
  34. Varlinskaya EI, Truxell E, Spear LP. Chronic intermittent ethanol exposure during adolescence: effects on social behavior and ethanol sensitivity in adulthood. 2014 Aug;48(5):433-44. doi: 10.1016/j.alcohol.2014.01.012. Epub 2014 May 15. PMID: 24928792; PMCID: PMC4096834.
  35. Vetreno RP, Broadwater M, Liu W, Spear LP, Crews FT. Adolescent, but not adult, binge ethanol exposure leads to persistent global reductions of choline acetyltransferase expressing neurons in brain. PLoS One. 2014 Nov 18;9(11):e113421. doi: 10.1371/journal.pone.0113421. eCollection 2014. PMID: 25405505; PMCID: PMC4236188.
  36. You C, Zhang H, Sakharkar AJ, Teppen T, Pandey SC. Reversal of deficits in dendritic spines, BDNF and Arc expression in the amygdala during alcohol dependence by HDAC inhibitor treatment. Int J Neuropsychopharmacol. 2014 Feb;17(2):313-22. doi: 10.1017/S1461145713001144. Epub 2013 Oct 9. PMID: 24103311; PMCID: PMC4093912.
  37. Zhang X, Kusumo H, Sakharkar AJ, Pandey SC, Guizzetti M. Regulation of DNA methylation by ethanol induces tissue plasminogen activator expression in astrocytes. J Neurochem. 2014 Feb;128(3):344-9. doi: 10.1111/jnc.12465. Epub 2013 Oct 28. PMID: 24117907; PMCID: PMC3946963.
  38. Zou JY, Crews FT. Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling. PLoS One. 2014 Feb 14;9(2):e87915. doi: 10.1371/journal.pone.0087915. eCollection 2014. PMID: 24551070; PMCID: PMC3925099.

2013:

  1. Acheson SK, Bearison C, Risher ML, Abdelwahab SH, Wilson WA, Swartzwelder HS. Effects of acute or chronic ethanol exposure during adolescence on behavioral inhibition and efficiency in a modified water maze task. PLoS One. 2013 Oct 17;8(10):e77768. doi: 10.1371/journal.pone.0077768. PMID: 24147077; PMCID: PMC3798405.
  2. Anderson RI, Bush PC, Spear LP. Environmental manipulations alter age differences in attribution of incentive salience to reward-paired cues. Behav Brain Res. 2013 Nov 15;257:83-9. doi: 10.1016/j.bbr.2013.09.021. Epub 2013 Sep 16. PMID: 24050888; PMCID: PMC3845669.
  3. Arora DS, Nimitvilai S, Teppen TL, McElvain MA, Sakharkar AJ, You C, Pandey SC, Brodie MS. Hyposensitivity to gamma-aminobutyric acid in the ventral tegmental area during alcohol withdrawal: reversal by histone deacetylase inhibitors. Neuropsychopharmacology. 2013 Aug;38(9):1674-84. doi: 10.1038/npp.2013.65. Epub 2013 Mar 8. PMID: 23474591; PMCID: PMC3717553.
  4. Broadwater M, Spear LP. Consequences of ethanol exposure on cued and contextual fear conditioning and extinction differ depending on timing of exposure during adolescence or adulthood. Behav Brain Res. 2013 Nov 1;256:10-9. doi: 10.1016/j.bbr.2013.08.013. Epub 2013 Aug 9. PMID: 23938333; PMCID: PMC3816365.
  5. Broadwater M, Spear LP. Age differences in fear retention and extinction in male Sprague-Dawley rats: effects of ethanol challenge during conditioning. Behav Brain Res. 2013 Sep 1;252:377-87. doi: 10.1016/j.bbr.2013.06.029. Epub 2013 Jun 27. PMID: 23810415; PMCID: PMC3763748.
  6. Broadwater M, Varlinskaya EI, Spear LP. Effects of voluntary access to sweetened ethanol during adolescence on intake in adulthood. Alcohol Clin Exp Res. 2013 Jun;37(6):1048-55. doi: 10.1111/acer.12049. Epub 2012 Dec 27. PMID: 23278242; PMCID: PMC3657579.
  7. Crews FT, Qin L, Sheedy D, Vetreno RP, Zou J. High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence. Biol Psychiatry. 2013 Apr 1;73(7):602-12. doi: 10.1016/j.biopsych.2012.09.030. Epub 2012 Dec 1. PMID: 23206318; PMCID: PMC3602398.
  8. Criado JR, Ehlers CL. Effects of adolescent onset voluntary drinking followed by ethanol vapor exposure on subsequent ethanol consumption during protracted withdrawal in adult Wistar rats. Pharmacol Biochem Behav. 2013 Jan;103(3):622-30. doi: 10.1016/j.pbb.2012.10.016. Epub 2012 Nov 2. PMID: 23128022; PMCID: PMC3544970.
  9. Ehlers CL, Liu W, Wills DN, Crews FT. Periadolescent ethanol vapor exposure persistently reduces measures of hippocampal neurogenesis that are associated with behavioral outcomes in adulthood. Neuroscience. 2013 Aug 6;244:1-15. doi: 10.1016/j.neuroscience.2013.03.058. Epub 2013 Apr 6. PMID: 23567812; PMCID: PMC3726260.
  10. Ehlers CL, Desikan A, Wills DN. Developmental differences in EEG and sleep responses to acute ethanol administration and its withdrawal (hangover) in adolescent and adult Wistar rats. Alcohol. 2013 Dec;47(8):601-10. doi: 10.1016/j.alcohol.2013.09.040. Epub 2013 Oct 3. PMID: 24169089; PMCID: PMC3896376.
  11. Ehlers CL, Oguz I, Budin F, Wills DN, Crews FT. Peri-adolescent ethanol vapor exposure produces reductions in hippocampal volume that are correlated with deficits in prepulse inhibition of the startle. Alcohol Clin Exp Res. 2013 Sep;37(9):1466-75. doi: 10.1111/acer.12125. Epub 2013 Apr 11. PMID: 23578102; PMCID: PMC3715576.
  12. Fleming RL, Li Q, Risher ML, Sexton HG, Moore SD, Wilson WA, Acheson SK, Swartzwelder HS. Binge-pattern ethanol exposure during adolescence, but not adulthood, causes persistent changes in GABAA receptor-mediated tonic inhibition in dentate granule cells. Alcohol Clin Exp Res. 2013 Jul;37(7):1154-60. doi: 10.1111/acer.12087. Epub 2013 Feb 15. PMID: 23413887; PMCID: PMC3754782.
  13. Gass JT, Chandler LJ. The Plasticity of Extinction: Contribution of the Prefrontal Cortex in Treating Addiction through Inhibitory Learning. Front Psychiatry. 2013 May 30;4:46. doi: 10.3389/fpsyt.2013.00046. PMID: 23750137; PMCID: PMC3667556.
  14. Grauer M, Reynolds P, Hoogstoel M, Budin F, Styner MA, Oguz I. A midas plugin to enable construction of reproducible web-based image processing pipelines. Front Neuroinform. 2013 Dec 30;7:46. doi: 10.3389/fninf.2013.00046. PMID: 24416016; PMCID: PMC3875239.
  15. Hay RA, Jennings JH, Zitzman DL, Hodge CW, Robinson DL. Specific and nonspecific effects of naltrexone on goal-directed and habitual models of alcohol seeking and drinking. Alcohol Clin Exp Res. 2013 Jul;37(7):1100-10. doi: 10.1111/acer.12081. Epub 2013 Feb 7. PMID: 23398292; PMCID: PMC3655078.
  16. Kuhn CM, Wilson W, Swartzwelder S. Enduring effects of adolescent drug exposure. Biol Psychiatry. 2013 Oct 1;74(7):480-1. doi: 10.1016/j.biopsych.2013.07.030. PMID: 24034365; PMCID: PMC4076785.
  17. Lee J, Lyu I, Oğuz I, Styner MA. Particle-guided image registration. Med Image Comput Comput Assist Interv. 2013;16(Pt 3):203-10. PMID: 24505762; PMCID: PMC3974564.
  18. Li Q, Fleming RL, Acheson SK, Madison RD, Moore SD, Risher ML, Wilson WA, Swartzwelder HS. Long-term modulation of A-type K(+) conductances in hippocampal CA1 interneurons in rats after chronic intermittent ethanol exposure during adolescence or adulthood. Alcohol Clin Exp Res. 2013 Dec;37(12):2074-85. doi: 10.1111/acer.12204. Epub 2013 Jul 26. PMID: 23889304; PMCID: PMC4088965.
  19. Logrip ML, Rivier C, Lau C, Im S, Vaughan J, Lee S. Adolescent alcohol exposure alters the rat adult hypothalamic-pituitary-adrenal axis responsiveness in a sex-specific manner. Neuroscience. 2013 Apr 3;235:174-86. doi: 10.1016/j.neuroscience.2012.12.069. Epub 2013 Jan 18. PMID: 23337533; PMCID: PMC3595399.
  20. Moonat S, Sakharkar AJ, Zhang H, Tang L, Pandey SC. Aberrant histone deacetylase2-mediated histone modifications and synaptic plasticity in the amygdala predisposes to anxiety and alcoholism. Biol Psychiatry. 2013 Apr 15;73(8):763-73. doi: 10.1016/j.biopsych.2013.01.012. Epub 2013 Feb 26. PMID: 23485013; PMCID: PMC3718567.
  21. Oguz I, Yaxley R, Budin F, Hoogstoel M, Lee J, Maltbie E, Liu W, Crews FT. Comparison of magnetic resonance imaging in live vs. post mortem rat brains. PLoS One. 2013 Aug 13;8(8):e71027. doi: 10.1371/journal.pone.0071027. PMID: 23967148; PMCID: PMC3742751.
  22. Qin L, Liu Y, Hong JS, Crews FT. NADPH oxidase and aging drive microglial activation, oxidative stress, and dopaminergic neurodegeneration following systemic LPS administration. Glia. 2013 Jun;61(6):855-68. doi: 10.1002/glia.22479. Epub 2013 Mar 28. PMID: 23536230; PMCID: PMC3631289.
  23. Risher ML, Fleming RL, Boutros N, Semenova S, Wilson WA, Levin ED, Markou A, Swartzwelder HS, Acheson SK. Long-term effects of chronic intermittent ethanol exposure in adolescent and adult rats: radial-arm maze performance and operant food reinforced responding. PLoS One. 2013 May 13;8(5):e62940. doi: 10.1371/journal.pone.0062940. PMID: 23675442; PMCID: PMC3652810.
  24. Spear LP. Adolescent neurodevelopment. J Adolesc Health. 2013 Feb;52(2 Suppl 2):S7-13. doi: 10.1016/j.jadohealth.2012.05.006. PMID: 23332574; PMCID: PMC3982854.
  25. Varlinskaya EI, Truxell EM, Spear LP. Repeated restraint stress alters sensitivity to the social consequences of ethanol differentially in early and late adolescent rats. Pharmacol Biochem Behav. 2013 Nov 15;113:38-45. doi: 10.1016/j.pbb.2013.10.016. Epub 2013 Oct 23. PMID: 24161685; PMCID: PMC3889217.
  26. Varlinskaya EI, Vetter-O’Hagen CS, Spear LP. Puberty and gonadal hormones: role in adolescent-typical behavioral alterations. Horm Behav. 2013 Jul;64(2):343-9. doi: 10.1016/j.yhbeh.2012.11.012. PMID: 23998677; PMCID: PMC3761212.
  27. Vetreno RP, Qin L, Crews FT. Increased receptor for advanced glycation end product expression in the human alcoholic prefrontal cortex is linked to adolescent drinking. Neurobiol Dis. 2013 Nov;59:52-62. doi: 10.1016/j.nbd.2013.07.002. Epub 2013 Jul 15. PMID: 23867237; PMCID: PMC3775891.

2012:

  1. Coleman LG Jr, Oguz I, Lee J, Styner M, Crews FT. Postnatal day 7 ethanol treatment causes persistent reductions in adult mouse brain volume and cortical neurons with sex specific effects on neurogenesis. Alcohol. 2012 Sep;46(6):603-12. doi: 10.1016/j.alcohol.2012.01.003. Epub 2012 May 7. PMID: 22572057; PMCID: PMC3552379.
  2. Crews FT. Immune function genes, genetics, and the neurobiology of addiction. Alcohol Res. 2012;34(3):355-61. PMID: 23134052; PMCID: PMC3860409.
  3. Ehlers CL, Wills DN, Havstad J. Ethanol reduces the phase locking of neural activity in human and rodent brain. Brain Res. 2012 Apr 23;1450:67-79. doi: 10.1016/j.brainres.2012.02.039. Epub 2012 Feb 22. PMID: 22410292; PMCID: PMC3503530.
  4. Fleming RL, Acheson SK, Moore SD, Wilson WA, Swartzwelder HS. In the rat, chronic intermittent ethanol exposure during adolescence alters the ethanol sensitivity of tonic inhibition in adulthood. Alcohol Clin Exp Res. 2012 Feb;36(2):279-85. doi: 10.1111/j.1530-0277.2011.01615.x. Epub 2011 Oct 20. PMID: 22014205; PMCID: PMC3732030.
  5. Moonat S, Pandey SC. Stress, epigenetics, and alcoholism. Alcohol Res. 2012;34(4):495-505. PMID: 23584115; PMCID: PMC3860391.
  6. Oguz I, McMurray MS, Styner M, Johns JM. The translational role of diffusion tensor image analysis in animal models of developmental pathologies. Dev Neurosci. 2012;34(1):5-19. doi: 10.1159/000336825. Epub 2012 May 24. PMID: 22627095; PMCID: PMC3566876.
  7. Pandey SC. TLR4-MyD88 signalling: a molecular target for alcohol actions. Br J Pharmacol. 2012 Mar;165(5):1316-8. doi: 10.1111/j.1476-5381.2011.01695.x. PMID: 21955082; PMCID: PMC3372717.
  8. Qin L, Crews FT. Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration. J Neuroinflammation. 2012 Jun 18;9:130. doi: 10.1186/1742-2094-9-130. PMID: 22709825; PMCID: PMC3412752.
  9. Sakharkar AJ, Zhang H, Tang L, Shi G, Pandey SC. Histone deacetylases (HDAC)-induced histone modifications in the amygdala: a role in rapid tolerance to the anxiolytic effects of ethanol. Alcohol Clin Exp Res. 2012 Jan;36(1):61-71. doi: 10.1111/j.1530-0277.2011.01581.x. Epub 2011 Jul 25. PMID: 21790673; PMCID: PMC3208078.
  10. Semenova S Attention, impulsivity, and cognitive flexibility in adult male rats exposed to ethanol binge during adolescence as measured in the five-choice serial reaction time task: the effects of task and ethanol challenges. Psychopharmacology (Berl). 2012 Jan;219(2):433-42. doi: 10.1007/s00213-011-2458-2. Epub 2011 Sep 1. PMID: 21881872; PMCID: PMC4018242.
  11. Swartzwelder NA, Risher ML, Abdelwahab SH, D’Abo A, Rezvani AH, Levin ED, Wilson WA, Swartzwelder HS, Acheson SK. Effects of ethanol, Δ(9)-tetrahydrocannabinol, or their combination on object recognition memory and object preference in adolescent and adult male rats. Neurosci Lett. 2012 Oct 3;527(1):11-5. doi: 10.1016/j.neulet.2012.08.037. Epub 2012 Aug 29. PMID: 22959891; PMCID: PMC3477605.
  12. Vetreno RP, Crews FT. Adolescent binge drinking increases expression of the danger signal receptor agonist HMGB1 and Toll-like receptors in the adult prefrontal cortex. 2012 Dec 13;226:475-88. doi: 10.1016/j.neuroscience.2012.08.046. Epub 2012 Sep 15. PMID: 22986167; PMCID: PMC3740555.
  13. Zou J, Crews FT. Inflammasome-IL-1β signaling mediates ethanol inhibition of hippocampal neurogenesis. Front Neurosci. 2012 May 30;6:77. doi: 10.3389/fnins.2012.00077. eCollection 2012. PMID: 22661925; PMCID: PMC3362805.
  14. Zou J, Vetreno RP, Crews FT. ATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation. 2012 Apr;60(4):661-73. doi: 10.1002/glia.22302. Epub 2012 Feb 1. PMID: 22298391; PMCID: PMC3276752.

2011:

  1. Allen CD, Lee S, Koob GF, Rivier C. Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats. Brain Behav Immun. 2011 Jun;25 Suppl 1(Suppl 1):S50-60. doi: 10.1016/j.bbi.2011.01.016. Epub 2011 Feb 12. PMID: 21300146; PMCID: PMC3098294.
  2. Allen CD, Rivier CL, Lee SY. Adolescent alcohol exposure alters the central brain circuits known to regulate the stress response. NeuroscienceNeuroscience. 2011 May 19;182:162-8. doi: 10.1016/j.neuroscience.2011.03.003. Epub 2011 Mar 5. PMID: 21382450; PMCID: PMC3085552.
  3. Boucharin A, Oguz I, Vachet C, Shi Y, Sanchez M, Styner M. Efficient, graph-based white matter connectivity from orientation distribution functions via multi-directional graph propagation. Proc SPIE Int Soc Opt Eng. 2011;7962:79620S. doi: 10.1117/12.878291. Epub 2011 Mar 7. PMID: 23066452; PMCID: PMC3468156.
  4. Coleman LG Jr, He J, Lee J, Styner M, Crews FT. Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice. Alcohol Clin Exp Res. 2011 Apr;35(4):671-88. doi: 10.1111/j.1530-0277.2010.01385.x. Epub 2011 Jan 11. PMID: 21223304; PMCID: PMC3544413.
  5. Crews FT, Zou J, Qin L. Induction of innate immune genes in brain create the neurobiology of addiction. Brain Behav Immun. 2011 Jun;25 Suppl 1(Suppl 1):S4-S12. doi: 10.1016/j.bbi.2011.03.003. Epub 2011 Mar 21. PMID: 21402143; PMCID: PMC3552373.
  6. Criado JR, Liu T, Ehlers CL, Mathé AA. Prolonged chronic ethanol exposure alters neuropeptide Y and corticotropin-releasing factor levels in the brain of adult Wistar rats. Pharmacol Biochem Behav. 2011 Jul;99(1):104-11. doi: 10.1016/j.pbb.2011.04.005. Epub 2011 Apr 17. PMID: 21527271; PMCID: PMC3120013
  7. Ehlers CL, Criado JR, Wills DN, Liu W, Crews FT. Adolescent ethanol exposure produces reductions in ChAT-IR in the Nucleus Basalis: correlation with behavioral pathology. 2011 Oct 18;199:333-45. PMID: 22033458; PMCID: PMC3264427.
  8. Ehlers CL, Criado JR, Wills DN, Liu W, Crews FT. Periadolescent ethanol exposure reduces adult forebrain ChAT+IR neurons: correlation with behavioral pathology. 2011 Dec 29;199:333-45. doi: 10.1016/j.neuroscience.2011.10.011. Epub 2011 Oct 18. PMID: 22033458; PMCID: PMC3264427.
  9. Fleming RL, Acheson SK, Moore SD, Wilson WA, Swartzwelder HS. GABA transport modulates the ethanol sensitivity of tonic inhibition in the rat dentate gyrus. Alcohol. 2011 Sep;45(6):577-83. doi: 10.1016/j.alcohol.2011.03.003. Epub 2011 May 19. PMID: 21600727; PMCID: PMC3155262.
  10. Hashemi P, Walsh PL, Guillot TS, Gras-Najjar J, Takmakov P, Crews FT, Wightman RM. Chronically implanted, nafion-coated Ag/AgCl reference electrodes for neurochemical applications. ACS Chem Neurosci. 2011 Nov 16;2(11):658-666. doi: 10.1021/cn2000684. PMID: 22125666; PMCID: PMC3224088.
  11. Lee J, Ehlers C, Crews F, Niethammer M, Budin F, Paniagua B, Sulik K, Johns J, Styner M, Oguz I. Automatic cortical thickness analysis on rodent brain. Proc SPIE Int Soc Opt Eng. 2011 Mar 15;7962:7962481-79624811. doi: 10.1117/12.878305. PMID: 21909228; PMCID: PMC3168533.
  12. Oguz I, Lee J, Budin F, Rumple A, McMurray M, Ehlers C, Crews F, Johns J, Styner M. Automatic skull-stripping of rat MRI/DTI scans and atlas building. Proc SPIE Int Soc Opt Eng. 2011 Mar;7962:7962251-7962257. doi: 10.1117/12.878405. PMID: 21909227; PMCID: PMC3168953.
  13. Robinson DL, Zitzman DL, Williams SK. Mesolimbic dopamine transients in motivated behaviors: focus on maternal behavior. Front Psychiatry. 2011 May 9;2:23. doi: 10.3389/fpsyt.2011.00023. PMID: 21629844; PMCID: PMC3098725.
  14. Spear LP. Rewards, aversions and affect in adolescence: emerging convergences across laboratory animal and human data. Dev Cogn Neurosci. 2011 Oct;1(4):392-400. doi: 10.1016/j.dcn.2011.08.001. PMID: 21918675; PMCID: PMC3170768.

2010:

  1. Criado JR, Ehlers CL. Effects of adolescent ethanol exposure on event-related oscillations (EROs) in the hippocampus of adult rats. Behav Brain Res. 2010 Feb 15; 210(2): 164-170. PMID: 20170688; PMCID: 2862110.
  2. Ehlers CL, Criado JR. Adolescent ethanol exposure: does it produce long-lasting electrophysiological effects? 2010 Feb;44(1):27-37. PMID: 20113872; PMCID: PMC2818286.
  3. Hansson AC, Nixon K, Rimondini R, Damadzic R, Sommer WH, Eskay R, Crews FT, Heilig M. Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats. Int J Neuropsychopharmacol. 2010 Jun;13(5):583-93. doi: 10.1017/S1461145710000246. Epub 2010 Mar 25. PMID: 20334723; PMCID: PMC4821191.
  4. Pian JP, Criado JR, Milner R, Ehlers CL. N-methyl-d-aspartate receptor subunit expression in adult and adolescent brain following chronic ethanol exposure. 2010 Oct 13;170(2):645-54. doi: 10.1016/j.neuroscience.2010.06.065. Epub 2010 Jul 17. PMID: 20603193; PMCID: PMC2945397.