Welcome to the Bioinformatics and Analytics Research Collaborative (BARC)
Open to all, focused on unmet need
Introduction: Emerging data suggests liver disease may be initiated during development when there is high genome plasticity and the molecular pathways supporting liver function are being developed.
Abstract Regulation of chromatin states is essential for proper temporal and spatial gene expression. Chromatin states are modulated by remodeling complexes composed of components that have enzymatic activities. CHD4 is the catalytic core of the nucleosome remodeling and deacetylase (NuRD) complex, which represses gene transcription. However, it remains to be determined how CHD4, a ubiquitous … Read more
Summary Tardigrades can survive remarkable doses of ionizing radiation, up to about 1,000 times the lethal dose for humans. How they do so is incompletely understood. We found that the tardigrade Hypsibius exemplaris suffers DNA damage upon gamma irradiation, but the damage is repaired. We show that this species has a specific and robust … Read more
About Us
The Bioinformatics and Analytics Research Collaborative (BARC) at the University of North Carolina at Chapel Hill is a multi disciplinary center that aims to provide bioinformatics expertise and analysis to researchers across the university and beyond for high throughput data. We analyze, visualize, interpret, and manage big data while also offering custom solutions to fit our researchers’ needs. Additionally, the center strives to educate researchers on current tools and techniques, foster a collaborative environment by hosting workshops, working groups, and seminars, and improve existing tools and/or invent new tools and algorithms.
How We Work
We offer a free initial consultation for incoming projects during which we discuss the client’s project and how to ensure they are able to maximize the information that they learn. Afterwards, depending on the scale of the project we provide services by the hours or staff for grant for projects longer than six months. Each project is assigned to a project coordinator and bioinformaticist. The project coordinator is the point of contact for the client and is responsible for updating them on the status of their project.
