Acute myeloid leukemia-associated thrombosis and bleeding

Acute myeloid leukemia (AML) is associated with both venous thrombosis and bleeding. However, the mediators underlying these complications have not yet been elucidated. We have recently developed a mouse xenograft model of AML that mimics human disease, and we are currently establishing a mouse allograft model of AML. Using these models, we aim to investigate the mechanisms by which AML induces venous thrombosis and bleeding.