The UNC Blood Research Center (BRC) was established to promote interdisciplinary research in non-malignant blood disorders across UNC. It will seek to advance the work in the following specific areas.
One in four of the US population will succumb to a terminal thrombotic event, such as: myocardial infarction, stroke, or venous thromboembolism.
Basic science discoveries have paved the way towards better prophylactic and therapeutic approaches to thrombosis. However, a better understanding of the mechanisms underlying thrombosis and prevention without any risk of bleeding remains an unmet need. The BRC seeks to investigate potential approaches to both aims.
UNC is a world leader in hemophilia, from the development and administration of the first coagulation factor VIII concentrate to the role of the Chapel Hill dog colonies of the Francis Owen Blood Research Center in the pre-clinical testing of protein and gene therapies. The BRC aims to address the broad challenges that remain in numerous other inherited and acquired bleeding disorders.
Sickle cell disease affects approximately 100,000 Americans but accounts for an estimated 300,000 births worldwide every year, primarily in sub-Saharan Africa and the Indian sub-continent.
Compared to many other areas of medicine, the development of impactful therapies in sickle cell disease remains inadequate. We will continue to expand our research efforts to this under-served patient population into the future.
Friday 11:00 am
Tuesday 9:00 am
Friday 11:00 am
Friday 11:00 am
1 minute ago
Matthew Vander Ploeg, a graduate student in BCBP and a member of the BRC in Dr. Bergmeier’s lab, published his first author manuscript in Blood Advances. The study describes the development of high-throughput platelet migration assay, facilitated by novel deep learning-based image analysis pipeline. Using this new platform, Matt was able to show that platelet …
22 hours ago
Dr. Yohei Hisada delivered an invited talk during a plenary session at the International Conference on Thrombosis and Hemostasis Issues in Cancer (https://icthic.com/en). The title of the presentation was “Tissue Factor-Driven Coagulopathy and Bleeding in Acute Leukemia: Clinical and Preclinical Insights.”
2 weeks ago
David Paul, PhD (Assistant Professor) and David Rocco (graduate student, Cell Biology and Physiology) from the Bergmeier lab publish co-first author paper in Blood describing a new signaling pathway critical for platelet adhesion under arterial shear conditions. The findings of this study markedly improve our understanding of G protein signaling and integrin function in platelets, …