Genetics and Molecular Biology Graduate Student Mark Geisler in the lab of Bob Duronio published a paper titled “Cell-cycle-regulated transcriptional pausing of Drosophila replication-dependent histone genes” in the August 2025 issue of Molecular Biology of the Cell.
Read paper HERE.
See Cover Art HERE.
By detecting nascent transcripts using high resolution fluorescent in situ hybridization of endogenous Drosophila tissues, Mark Geisler together with his research associate colleague Jim Kemp in the Duronio lab demonstrated that activation of histone gene expression during S phase occurs by stimulating paused RNA pol II to transition into active transcription elongation, rather than by triggering transcription initiation.