Category: Publication

Kaitlin Koreski (Bob Duronio lab) published a paper titled “Drosophila histone locus body assembly and function involves multiple interactions” in Molecular Biology of the Cell (DOI:10.1091/mbc.E20-03-0176). Image: FLASH and GAF in polytene chromosomes with a 12x histone array transgene; click to enlarge; see article for details).   Please see Publications...

Nicole Arruda (Jill Dowen lab) published a paper titled “Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells” in Epigenetics and Chromatin (DOI:10.1186/s13072-020-00353-9). GMB student Megan Justice is a co-author. Image: Heatmaps of expression changes in Stag1 and Stag2 mutant cells...

Amanda Raimer (Greg Matera lab) published an article titled “Temperature-sensitive spinal muscular atrophy-causing point mutations lead to SMN instability, locomotor defects and premature lethality in Drosophila” in Disease Models and Mechanisms. (DOI: 10.1242/dmm.04330)  Image: Temperature-sensitive protein stability in SMN Tudor domain mutants. Please see our page on Publications by GMB...

Meng Cheng (Yue Xiong lab) published a paper titled “Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders” in J. Medicinal Chemistry (DOI: 10.1021/acs.jmedchem.9b01566). Image: Hi-C maps showing signal in wild-type and Wiz deletion cells (see article for details; click to enlarge). Please see our page...

Megan Justice (Jill Dowen lab) published a paper titled “A WIZ/Cohesin/CTCF complex anchors DNA loops to define gene expression and cell identity” in Cell Reports (DOI: 10.1016/j.celrep.2020.03.067). Image: Hi-C maps showing signal in wild-type and Wiz deletion cells (see article for details; click to enlarge). Please see our page on...

Spencer Nystrom and Matt Niederhuber (Dan McKay lab) published a paper titled “Expression of E93 provides an instructive cue to control dynamic enhancer activity and chromatin accessibility during development” in Development (DOI: 10.1242/dev.181909). Image: Composite image of precocious activity of an enhancer in an imaginal disc and genomics data plotted...

Juan Carvajal Garcia (Dale Ramsden lab and Jeff Sekelsky lab) published an article titled “Mechanistic basis for microhomology identification and genome scarring by polymerase theta” in Proceedings of the National Academy of Sciences (DOI: 10.1073/pnas.1921791117).  Image: Model for generation of templated insertions durng theta-mediated repair; see article for details. Please...

Kendall Lough (Scott Williams lab) published an article titled “Telophase correction refines division orientation in stratified epithelia” in eLife (DOI: 10.7554/eLife.49249). Image: Movie showing division of a basal cell that starts at an oblique angle but corrects; click for animatino; see article for details. Please see our page on Publications...

Ricardo Rivera-Soto (Blossom Damania lab) published an article titled “Kaposi’s sarcoma-associated herpesvirus viral interleukin 6 signaling upregulates Integrin Beta 3 Levels and is Dependent on STAT3” in Journal of Virology (DOI: 10.1128/JVI.01384-19). Image; Model of vIL-6 induction of ITGB3; see article for details. Please see our page on Publications by...

Adelaide Tovar (Samir Kelada lab) published an article titled “Transcriptional profiling of the murine airway response to acute ozone exposure” in Toxicological Sciences (DOI: 110.1093/toxsci/kfz219). Image; Partial heatmap of gene expression in airway macrophages; see article for details. Please see our page on Publications by GMB Students for more.

Talia Hatkevich (Jeff Sekelsky lab) published an article titled “Centromeric SMC1 promotes centromere clustering and stabilizes meiotic homolog pairing” in PLOS Genetics (DOI: 10.1371/journal.pgen.1008412). Image:FISH on meiotic chromosomes showing lack of pairing (two foci) despite synaptonemal complex (magenta); click in image for 3D animation; see article for details. Please see...

Vicki Madigan (Aravind Asokan lab) published an article titled “A CRISPR screen identifies the cell polarity determinant Crumbs 3 as an adeno-associated virus restriction factor in hepatocytes” in Journal of VIrology (DOI: 10.1128/JVI.00943-19). Image: Outline of the high-throughput CRISPR screen for AAV restriction factors; see article for details. Please see...