Category: Publication

Vicki Madigan (Aravind Asokan lab) published an article titled “A CRISPR screen identifies the cell polarity determinant Crumbs 3 as an adeno-associated virus restriction factor in hepatocytes” in Journal of VIrology (DOI: 10.1128/JVI.00943-19). Image: Outline of the high-throughput CRISPR screen for AAV restriction factors; see article for details. Please see...

Rebekah Watkins-Schultz (Jenny Ting lab) published an article titled “A microparticle platform for STING-targeted immunotherapy enhances natural killer cell- and CD8+ T cell-mediated anti-tumor immunity” in Biomaterials (DOI: 10.1016/j.biomaterials.2019.03.011). Image: Flow cytometry to detect tumor-infiltrating leukocytes after microparticle injection; see article for details. Please see our page on Publications by...

Kale Hartmann (Jeff Sekelsky lab) published an article titled “Centromere-proximal meiotic crossovers in Drosophila melanogaster are suppressed by both highly repetitive heterochromatin and proximity to the centromere” in Genetics (DOI: 10.1534/genetics.119.302509).The article was chosen for Highlights by the editors.  Image:Relationship of genome features (gene and TE density) to crossover density...

David Lee (Mauro Calabrese lab) published a paper titled “A 5′ fragment of Xist can sequester RNA produced from adjacent genes on chromatin“ in Nucleic Acids Research (DOI:10.1093/nar/gkz432). GMB students Rachel Cherney and Megan Schertzer are co-authors. Image: The TETRIS reporter demonstrates that Xist-2kb represses luciferase at the post-transcriptional level;...

Claire Trincot (Kathleen Caron lab) published a paper titled “Adrenomedullin induces cardiac lymphangiogenesis after myocardial infarction and regulates cardiac edema via connexin 43“ in Circulation Research (DOI:10.1161/CIRCRESAHA.118.313835). Image: Immunohistochemistry of cardiac sections in infarcted adult Adm+/+ and Admhi/hi mice; see article for details. See also the commentary on this article:...

Kale Hartmann and Talia Hatkevich (Jeff Sekelsky lab) published an article titled “Meiotic MCM proteins promote and inhibit crossovers during meiotic recombination.” in Genetics (DOI: 10.1534/genetics.119.302221). Image:Schematic of meiotic MCM protein structures; see article for details. Please see our page on Publications by GMB Students for more.

Katie Headley (Nate Hathaway lab) published a paper titled “Chemical screen for epigenetic barriers to single allele activation of Oct4“ in Stem Cell Research (DOI: 10.1016/j.scr.2019.101470). Image: Results of a small molecule screen for chemical facilitators of CiA:Oct4 activation; see article for details. Please see our page on Publications by...

Salma Azam (Chad Pecot lab) published an article titled “Quaking orchestrates a post-transcriptional regulatory network of endothelial cell cycle progression critical to angiogenesis and metastasis” in Oncogene. (DOI: 10.1038/s41388-019-0786-6)  Image:Perturbation of the Quaking/miR-200 pathway inhibits endothelial sprouting; click to enlarge; see article for details. Please see our page on Publications...

Chris Uyehara (Dan McKay lab) published a paper titled “Direct and widespread role for the nuclear receptor EcR in mediating the response to ecdysone in Drosophila” in Proceedings of the National Academy of Sciences (DOI: 10.1073/pnas.1900343116). Image: Expression of the broad gene without and with expression of an ecdysone receptor;...

Casey Schmidt (Greg Matera lab) published an article titled “Molecular determinants of metazoan tricRNA biogenesis” in Nucleic Acids Research. (DOI: 110.1093/nar/gkz311)  Image: tRNA splicing pathways; click to enlarge; see article for details. Please see our page on Publications by GMB Students for more.

Tim Dinh (Praveen Sethupathy lab) published an article titled “MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma” in Cellular and Molecular Gastroenterology and Hepatology. Image: miR-375 is a candidate master regulator of cancer pathways in FLC; click to enlarge; see article for details.) Please see our page on Publications...

Kristi Schaefer (recent graduate of Mark Peifer lab) published a review article titled “Wnt/Beta-Catenin Signaling Regulation and a Role for Biomolecular Condensates” in Developmental Cell (DOI:10.1016/j.devcell.2019.01.025). Image: textbook model of Wnt signalling; click to enlarge; see article for details.) Please see our page on Publications by GMB Students for more.