Category: Publication

Robin Armstrong and Taylor Penke (Bob Duronio lab) published a paper titled “Chromatin conformation and transcriptional activity are permissive regulators of DNA replication initiation in Drosophila“ in Genome Research (DOI: 10.1101/gr.239913.118). Image: Replication timing in a 5 Mb region of pericentric heterochromatin in wild-type and Histone H3K9R mutants; see article...

Matt Tegowski (Al Baldwin lab) published a paper titled “Thioridazine inhibits self-renewal in breast cancer cells via DRD2-dependent STAT3 inhibition, but induces a G1 arrest independent of DRD2s“ in Journal of Biological Chemistry (DOI: 10.1074/jbc.RA118.003719). Image: Model describing mechanism of thioridazine effects on triple-negative breast cancer cell lines; see article...

Carrie Wilczewski (Frank Conlon lab) published a paper titled “CHD4 and the NuRD complex directly control cardiac sarcomere formation“ in Proceedings of the National Academy of Sciences of the USA (DOI: 10.1073/pnas.1722219115). Image: Scanning electron micrographs of Chd4Δflox/Δflox and control hearts; see article for details. Please see our page on...

Anna Chiarella (Nate Hathaway lab) published a paper titled “Cavitation enhancement increases the efficiency and consistency of chromatin fragmentation from fixed cells for downstream quantitative applications“ in Biochemistry (DOI: 10.1021/acs.biochem.8b00075). Image: 16-fold increase in efficiency of sonication when nanodroplets are used; see article for details. Please see our page on...

Ricky Antonia (Al Baldwin lab) published a paper titled “IKK promotes cytokine-induced and cancer-associated AMPK activity and attenuates phenformin-induced cell death in LKB1-deficient cells“ in Science Signaling (DOI: 10.1126/scisignal.aan5850). Image: IKK regulates basal AMPK Thr172 phosphorylation in cell lines; see article for details. Please see our page on Publications by...

Kristi Schaefer (Mark Peifer lab) published an article titled “Supramolecular assembly of the beta-catenin destruction complex and the effect of Wnt signaling on its localization, molecular size, and activity in vivo” in PLOS Genetics (DOI:10.1371/journal.pgen.1007339). Image: Accumulation of Arm, axin, and Wg in Drosophila embryos; click to enlarge; see article for...

Kelsey Gray (Greg Matera lab) published a paper titled “Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron“ in Molecular Biology of the Cell (DOI: 10.1091/mbc.E17-11-0627). Image: Proposed model of SMN as a substrate of SCFSlmb E3 ubiquitin ligase; see article for details. Please see...

Blake Albright (Aravind Asokan lab) published an article titled “Mapping the Structural Determinants Required for AAVrh.10 Transport across the Blood-Brain Barrier” in Molecular Therapy (DOI: 10.1016/j.ymthe.2017.10.017). Image: Mapping a minimal AAVrh.10 footprint for crossing the blood-brain barrier; see article for details.   Please see our page on Publications by GMB...

Morgan Brady (Jeff Sekelsky lab) published an article titled “Loss of Drosophila Mei-41/ATR Alters Meiotic Crossover Patterning” in Genetics (DOI: 10.1534/genetics.117.300634). Image: Changes in crossover interference in ATR mutants; see article for details. Please see our page on Publications by GMB Students for more.

Tamara Roman (Karen Mohlke lab) published a review titled “Functional genomics and assays of regulatory activity detect mechanisms at loci for lipid traits and coronary artery disease” in Current Opinion in Genetics and Development (DOI: 10.1016/j.gde.2018.02.004). Image: Chromatin regulatory annotations predict rs10872142 is located within an enhancer; see article for details....

Luke Laudermilk (Samir Kelada lab) published a paper titled “Differential regulation of Zfp30 expression in murine airway epithelia through altered binding of ZFP148 to rs51434084” in G3: Genes|Genomes|Genetics (DOI: 10.1534/g3.117.300507). Image: Differential ZFP148 binding demonstrated by electrophoretic mobility supershift assay super-shifting (click to enlarge); see article for details. Please see...

Katy Koreski (Bob Duronio lab) published a paper titled “Histone locus regulation by the Drosophila dosage compensation adaptor protein CLAMP“ in Genes and Development (DOI: 10.1101/gad.300855.117). Image (click to enlarge): Polytene chromosomes from Drosophila virilis showing localization of CLAMP and Gaga factor (see article for details). Please see our page...