Category: Publication

Mike Conlin (Dale Ramsden lab) published a paper titled “DNA ligase IV guides end-processing xhoice during nonhomologous end joining” in Cell Reports (DOI: 10.1016/j.celrep.2017.08.091). Image: Alignment of DNA Ligase IV to Lig I crystal structure, showing Lig IV region deleted by CRISPR/Cas9 (see article for details). Please see our page...

Taylor Penke (Bob Duronio lab) published a paper titled “Functional redundancy of variant and canonical histone H3 lysine 9 modification in Drosophila“ in Genetics (DOI: 10.1534/genetics.117.300480). Image: Heterochromatin marks in polytene chromosomes from wild-type and Histone H3.3 mutants (null and K9R missense (see article for details). Please see our page...

Charlie Hodgens (Joe Keiber lab) published a paper titled “indCAPS: A tool for designing screening primers for CRISPR/Cas9 mutagenesis events” in PLOS One (DOI: 10.1371/journal.pone.0188406). Image: A. thaliana seedlings imaged at 2.5 weeks of growth, showing phenotypes of CRISPR mutations in the cytokine gene AHK3 designed using the indCAPS tool....

Lauren Donoghue (Samir Kelada lab) published a paper titled “Identification of trans protein QTL for secreted airway mucins in mice and a causal role for Bpifb1” in Genetics (DOI: 10.1534/genetics.117.300211). Image: AB-PAS and MUC5B in airways of naïve or sensitized and challenged mice (click to enlarge); see article for details....

Talia Hatkevich (Jeff Sekelsky lab) published a Problems and Paradigms review titled “Bloom syndrome helicase in meiosis: Pro-crossover functions of an anti-crossover protein” in Bioessays (DOI: 10.1002/bies.201700073). Image: Model for Blm helicase in Drosophila meiosis. click to magnify; see article for details. Please see our page on Publications by GMB...

Jordan Kardos (William Kim lab) published a paper titled “Comprehensive molecular characterization of urachal adenocarcinoma reveals commonalities with colorectal cancer, including a hypermutable phenotype” in JCO Precision Oncology (DOI: 10.1200/PO.17.00027). Image: Comparison of mutations per Mb in bladder, colorectal, and urachal cancers; see article for details. Please see our page...

Aleisha Smith (William Kim lab) published a paper titled “MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma” in Nature Communications (DOI: 10.1038/ncomms15770). Former GMB student Sean Bailey is co-first author and Jordan Kardos is also an author. Image: Venn diagram of gene expression...

Chris Uyehara and Spencer Nystrom (Dan McKay lab) published a paper titled “Hormone-dependent control of developmental timing through regulation of chromatin accessibility” in Genes and Development (DOI: 10.1101/gad.298182.117). Matt Niederhuber was also an author. Image: Expression of nub in the developing wing; see article for details. Please see our page...

Josh Lawrimore (Kerry Bloom lab) published a paper titled “Microtubule dynamics drive enhanced chromatin motion and mobilize telomeres in response to DNA damage” in Molecular Biology fo the Cell (DOI: 10.1091/mbc.E16-12-0846). Image: Positioning of the telomere (green) within the nucleus; see paper for details. Please see our page on Publications by...

John Noto (Greg Matera lab) published a review titled “Engineering and expressing circular RNAs via tRNA splicing“ in RNA Biology (DOI: 10.1080/15476286.2017.1317911). Image: In vivo RNA circularization pathways; see article for details. Please see our page on Publications by GMB Students for more.

Sarah Renner (Jay Brenman lab) published a paper titled “Carbonic anhydrase III (Car3) is not required for fatty acid synthesis and does not protect against high-fat diet induced obesity in mice“ in PLOS One (DOI: 10.1371/journal.pone.0176502). Image: Alignment of cytosolic anhydrase sequences; see paper for details. Please see our page...

Joe Durand (Al Baldwin lab) published a chapter titled “Targeting IKK and NF-κB for Therapy“ in Advances in Protein Chemistry and Structural Biology: Chromatin Proteins and Transcription Factors as Therapeutic Targets (DOI: 10.1016/bs.apcsb.2016.11.006). Image: Canonical and non-canonical NF-κB pathways; see article for details. Please see our page on Publications by GMB...