Category: Publication

Stephanie Bellendir (Jeff Sekelsky lab) and Danielle Rognstad (Jeff Sekelsky and Dorothy Erie labs) published an article titled “Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates.” in Nucleic Acids Research (DOI: 10.1093/nar/gkx214). Image: Model for cleavage of Holliday junctions and flap substrates;...

Mike Meers (Greg Matera lab) published an article titled “Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity” in eLife. (DOI: 10.7554/eLife.23249)  Image: Hex-plot heatmap plotting novel, unannotated transcription start sites by their location relative to the boundaries of the nearest gene and change in...

Becky Bigler (Anne Taylor lab) published an article titled “Messenger RNAs localized to distal projections of human stem cell derived neurons” in Scientific Reports (DOI: 10.1038/s41598-017-00676-w) Image: Micrographs of somatic, axon, and dendritic compartments of neurons cultured within a microfluidic chambers during maturation; see article for details. Please see our page...

Tim Dinh (Praveen Sethupathy lab) published an article titled “Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma” in Scientific Reports (DOI: 10.1038/srep44653) Image: Hierarchical clustering of fibrolamellar carcinoma, hepatocellular carcinoma, and cholangiocarcinoma samples in TCGA.; see article for details. Please see...

Julie Korda Holsclaw (Jeff Sekelsky lab) published an article titled “Annealing of Complementary DNA Sequences During Double-Strand Break Repair in Drosophila Is Mediated by the Ortholog of SMARCAL1″ in Genetics (DOI: 10.1534/genetics.117.200238). Image: Reduction in SDSA in Marcal1 and BRCA2 mutants; see article for details. Please see our page on...

Ann Emery (Ron Swanstrom lab) published an article titled “Characterizing HIV-1 splicing using next generation sequencing” in Journal of Virology (DOI:10.1128/JVI.02515-16). Image: Splicing in founder and transmittend HIV-1 (click to enlarge; see article for details). Please see our page on Publications by GMB Students for more.

Greg Zapotoczny (Jeff Sekelsky lab) published an article titled “Human cell assays for synthesis-dependent strand annealing and crossing over during double-strand break repair” in G3: Genes|Genomes|Genetics (DOI:10.1534/g3.116.037390). Image: U2OS cells expression GFP (crossover) or GFP and mCherry (non-crossover) after double-strand break repair; see article for details. Please see our page...

Mira Pronobis (Mark Peifer lab) published an article titled “Reconstituting regulation of the canonical Wnt pathway by engineering a minimal β-catenin destruction machine” in Molecular Biology of the Cell (DOI:10.1091/mbc.E16-07-0557). Image: Superesolution microscopy (SIM) showing assembly into supermolecular puncta of Axin alone, Axin plus APC or the a designed chimera;...

Bailey Peck (Praveen Sethupathy lab) published an article titled “Functional transcriptomics in diverse intestinal epithelial cell types reveals robust microRNA sensitivity in intestinal stem cells to microbial status” in Journal of Biological Chemistry (DOI:10.1074/jbc.M116.770099). Bailey’s paper was featured in an article from the UNC Newsroom.  Image: Model of miR-375-3p-mediated effects of...

Bailey Peck (Praveen Sethupathy lab) published an article titled “Functional transcriptomics in diverse intestinal epithelial cell types reveals robust microRNA sensitivity in intestinal stem cells to microbial status” in Journal of Biological Chemistry (DOI:10.1074/jbc.M116.770099). Bailey’s paper was featured in an article from the UNC Newsroom.  Image: Model of miR-375-3p-mediated effects of...

Talia Hatkevich (Jeff Sekelsky lab) and Kathryn Kohl (former GMB student, currently Assistant Professor at Winthrop University) published an article titled “Bloom syndrome helicase promotes meiotic crossover patterning and homolog disjunction” in Current Biology (DOI:10.1016/j.cub.2016.10.055), highlighted in a Dispatch. GMB student Michaelyn Hartmann was a co-author. Image: Graphical abstract showing...

Christian Parobek (Jonathon Juliano lab) published an article titled “Selective sweep suggests transcriptional regulation may underlie Plasmodium vivax resilience to malaria control measures in Cambodia” in Proceedings of the National Academy of Sciences (Early Edition). Image: Manhattan plot of sites under strong selection; see article for details. Please see our...