Jason Stein, PhD
Associate Professor
Areas of Interest
Genetic effects on brain development and structure; psychiatric disorders; iPSCs; gene regulation; quantitative trait loci; GWAS; tissue clearing and light sheet imaging; organoids
About
- Department Affiliations:
- Department of Genetics; UNC Neuroscience Center
- Other UNC PhD Program Affiliations:
- Genetics and Molecular Biology; Bioinformatics and Computational Biology; Neuroscience
My Research
We are a lab exploring how variations in the genome change the structure and development of the brain, and in doing so, create risk for neuropsychiatric illness. We study genetic effects on multiple aspects of the human brain, from macroscale phenotypes like gross human brain structure measured with MRI to molecular phenotypes like gene expression and chromatin accessibility measured with genome-sequencing technologies. We use neural progenitor cells, a modifiable and high fidelity model system, as well as mouse models to understand how disease-associated variants affect brain development.